Voight Lab

Publications

We have created extensive scholarship around method development and analysis of genetic data in humans, the central focus of my lab.

My roots began in population genetics, aiming to understand how the genome reveals details of our evolutionary history. Today, we are very are active in the development of methods in population genomics, which include characterization of mutation rates and studies of natural selection in human populations.

We are actively interested in the genetic dissection of complex traits. The statistical pipelines that we have developed and applied over my career have resulting in discovery of thousands of loci for complex traits, focused on type 2 diabetes, cardiovascular disease, and liver disease. This also include mapping of genetic variation associated with molecular phenotypes (eQTLs, sQTLs, caQTLs, etc.) using bulk tissue, cell model, and even single-cell resources in tissues relevant to these endpoints (e.g., pancreas).

We also have an active interest in the application of Mendelian randomization (MR) to evaluate causal hypotheses between biomarkers and cardiometabolic endpoints, including most famously rejecting a protective role for HDL Cholesterol in heart disease.

I need to prettify the publication listing below (Work in progress)!

But feel free to follow the Pubmed and Google Scholar links below to see a full list of my publications.

All

Selected Works:

Discipline/Approach Areas:

Phenotypic Areas:

Consortia Work:

Approaches/Software:

2024

Trans-ancestral genome-wide association study of longitudinal pubertal height growth and shared heritability with adult health outcomes
Trans-ancestral genome-wide association study of longitudinal pubertal height growth and shared heritability with adult health outcomes
Jonathan P. Bradfield, Rachel L. Kember, Anna Ulrich, Zhanna Balkiyarova, Akram Alyass, ..., Inga Prokopenko, Benjamin F. Voight, Babette S. Zemel, Struan F. A. Grant, Diana L. Cousminer
Genome Biology   ·   16 Jan 2024   ·   doi:10.1186/s13059-023-03136-z

2023

Projecting genetic associations through gene expression patterns highlights disease etiology and drug mechanisms
Projecting genetic associations through gene expression patterns highlights disease etiology and drug mechanisms
Milton Pividori, Sumei Lu, Binglan Li, Chun Su, Matthew E. Johnson, ..., Benjamin F. Voight, Carsten Skarke, Marylyn D. Ritchie, Struan F. A. Grant, Casey S. Greene
Nature Communications   ·   09 Sep 2023   ·   doi:10.1038/s41467-023-41057-4
Deciphering the genetic architecture of atrial fibrillation offers insights into disease prediction, pathophysiology and downstream sequelae
Deciphering the genetic architecture of atrial fibrillation offers insights into disease prediction, pathophysiology and downstream sequelae
Shuai Yuan, Yuying Li, Lijuan Wang, Fengzhe Xu, Jie Chen, ..., Agneta Åkesson, Karl Michaëlsson, Xue Li, Xia Shen, Susanna C. Larsson
Cold Spring Harbor Laboratory   ·   25 Jul 2023   ·   doi:10.1101/2023.07.20.23292938
Regularized sequence-context mutational trees capture variation in mutation rates across the human genome
Regularized sequence-context mutational trees capture variation in mutation rates across the human genome
Christopher J. Adams, Mitchell Conery, Benjamin J. Auerbach, Shane T. Jensen, Iain Mathieson, Benjamin F. Voight
PLOS Genetics   ·   07 Jul 2023   ·   doi:10.1371/journal.pgen.1010807
Evaluating the Contribution of Cell Type–Specific Alternative Splicing to Variation in Lipid Levels
Evaluating the Contribution of Cell Type–Specific Alternative Splicing to Variation in Lipid Levels
Katerina A.B. Gawronski, William P. Bone, YoSon Park, Evanthia E. Pashos, Brandon M. Wenz, ..., Wenli Yang, Daniel J. Rader, Kiran Musunuru, Benjamin F. Voight, Christopher D. Brown
Circulation: Genomic and Precision Medicine   ·   01 Jun 2023   ·   doi:10.1161/CIRCGEN.120.003249
Evaluating the Contribution of Cell Type–Specific Alternative Splicing to Variation in Lipid Levels
Evaluating the Contribution of Cell Type–Specific Alternative Splicing to Variation in Lipid Levels
Katerina A.B. Gawronski, William P. Bone, YoSon Park, Evanthia E. Pashos, Brandon M. Wenz, ..., Wenli Yang, Daniel J. Rader, Kiran Musunuru, Benjamin F. Voight, Christopher D. Brown
Circulation: Genomic and Precision Medicine   ·   01 Jun 2023   ·   doi:10.1161/circgen.120.003249
G6PC2 controls glucagon secretion by defining the setpoint for glucose in pancreatic α-cells
G6PC2 controls glucagon secretion by defining the setpoint for glucose in pancreatic α-cells
Varun Bahl, Eric Waite, Reut Rifkind, Zenab Hamdan, Catherine Lee May, ..., Mark Tigue, Nicholas Manuto, Benjamin Glaser, Dana Avrahami, Klaus H. Kaestner
Cold Spring Harbor Laboratory   ·   24 May 2023   ·   doi:10.1101/2023.05.23.541901
Genetically proxied glucose-lowering drug target perturbation and risk of cancer: a Mendelian randomisation analysis
Genetically proxied glucose-lowering drug target perturbation and risk of cancer: a Mendelian randomisation analysis
James Yarmolinsky, Emmanouil Bouras, Andrei Constantinescu, Kimberley Burrows, Caroline J. Bull, ..., Peter Kraft, William J. Blot, Elio Riboli, Dipender Gill, Kostas K. Tsilidis
Diabetologia   ·   12 May 2023   ·   doi:10.1007/s00125-023-05925-4
Evaluation of the Performance of the RECODe Equation with the Addition of Polygenic Risk Scores for Adverse Cardiovascular Outcomes in Individuals with Type II Diabetes
Evaluation of the Performance of the RECODe Equation with the Addition of Polygenic Risk Scores for Adverse Cardiovascular Outcomes in Individuals with Type II Diabetes
Noah L. Tsao, Renae Judy, Michael G. Levin, Gabrielle Shakt, Benjamin F. Voight, Jinbo Chen, Scott M. Damrauer
Cold Spring Harbor Laboratory   ·   05 May 2023   ·   doi:10.1101/2023.05.03.23289457
Evaluation of plasma biomarkers for causal association with peripheral artery disease
Evaluation of plasma biomarkers for causal association with peripheral artery disease
Pranav Sharma, Michael G. Levin, Derek Klarin, Benjamin F. Voight, Philip S. Tsao, Scott M. Damrauer
Cold Spring Harbor Laboratory   ·   05 May 2023   ·   doi:10.1101/2023.05.05.23289560
Mendelian Randomization Analysis Reveals a Complex Genetic Interplay among Atopic Dermatitis, Asthma, and Gastroesophageal Reflux Disease
Mendelian Randomization Analysis Reveals a Complex Genetic Interplay among Atopic Dermatitis, Asthma, and Gastroesophageal Reflux Disease
Kwangmi Ahn, Raymond B. Penn, Satish Rattan, Reynold A. Panettieri, Benjamin F. Voight, Steven S. An
American Journal of Respiratory and Critical Care Medicine   ·   15 Jan 2023   ·   doi:10.1164/rccm.202205-0951OC
Mendelian Randomization Analysis Reveals a Complex Genetic Interplay among Atopic Dermatitis, Asthma, and Gastroesophageal Reflux Disease
Mendelian Randomization Analysis Reveals a Complex Genetic Interplay among Atopic Dermatitis, Asthma, and Gastroesophageal Reflux Disease
Kwangmi Ahn, Raymond B. Penn, Satish Rattan, Reynold A. Panettieri, Benjamin F. Voight, Steven S. An
American Journal of Respiratory and Critical Care Medicine   ·   15 Jan 2023   ·   doi:10.1164/rccm.202205-0951oc

2022

Genomics and phenomics of body mass index reveals a complex disease network
Genomics and phenomics of body mass index reveals a complex disease network
Jie Huang, Jennifer E. Huffman, Yunfeng Huang, Ítalo Do Valle, Themistocles L. Assimes, ..., Kelly Cho, Kyong-Mi Chang, Peter W. F. Wilson, Yan V. Sun, Christopher J. O’Donnell
Nature Communications   ·   29 Dec 2022   ·   doi:10.1038/s41467-022-35553-2
Genome-wide association and multi-trait analyses characterize the common genetic architecture of heart failure
Genome-wide association and multi-trait analyses characterize the common genetic architecture of heart failure
Michael G. Levin, Noah L. Tsao, Pankhuri Singhal, Chang Liu, Ha My T. Vy, ..., Christopher M. Haggerty, Jacob Joseph, Yan V. Sun, Benjamin F. Voight, Scott M. Damrauer
Nature Communications   ·   14 Nov 2022   ·   doi:10.1038/s41467-022-34216-6
Regularized sequence-context mutational trees capture variation in mutation rates across the human genome
Regularized sequence-context mutational trees capture variation in mutation rates across the human genome
Christopher J. Adams, Mitchell Conery, Benjamin J. Auerbach, Shane T. Jensen, Iain Mathieson, Benjamin F. Voight
Cold Spring Harbor Laboratory   ·   17 Oct 2022   ·   doi:10.1101/2022.10.14.512160
Polygenic Risk Scores in Alzheimer’s Disease Genetics: Methodology, Applications, Inclusion, and Diversity
Polygenic Risk Scores in Alzheimer’s Disease Genetics: Methodology, Applications, Inclusion, and Diversity
Kaylyn Clark, Yuk Yee Leung, Wan-Ping Lee, Benjamin Voight, Li-San Wang
Journal of Alzheimer's Disease   ·   30 Aug 2022   ·   doi:10.3233/JAD-220025
Large-scale genome-wide association study of coronary artery disease in genetically diverse populations
Large-scale genome-wide association study of coronary artery disease in genetically diverse populations
Catherine Tcheandjieu, Xiang Zhu, Austin T. Hilliard, Shoa L. Clarke, Valerio Napolioni, ..., Hua Tang, Yan V. Sun, Philip S. Tsao, Christopher J. O’Donnell, Themistocles L. Assimes
Nature Medicine   ·   01 Aug 2022   ·   doi:10.1038/s41591-022-01891-3
ColocQuiaL: a QTL-GWAS colocalization pipeline
ColocQuiaL: a QTL-GWAS colocalization pipeline
Brian Y Chen, William P Bone, Kim Lorenz, Michael Levin, Marylyn D Ritchie, Benjamin F Voight
Bioinformatics   ·   27 Jul 2022   ·   doi:10.1093/bioinformatics/btac512
Estimating the effect size of a hidden causal factor between SNPs and a continuous trait: a mediation model approach
Estimating the effect size of a hidden causal factor between SNPs and a continuous trait: a mediation model approach
Zhuoran Ding, Marylyn D. Ritchie, Benjamin F. Voight, Wei-Ting Hwang
Cold Spring Harbor Laboratory   ·   29 Jun 2022   ·   doi:10.1101/2022.06.28.497617
Epigenomic and transcriptomic analyses define core cell types, genes and targetable mechanisms for kidney disease
Epigenomic and transcriptomic analyses define core cell types, genes and targetable mechanisms for kidney disease
Hongbo Liu, Tomohito Doke, Dong Guo, Xin Sheng, Ziyuan Ma, ..., Hongzhe Li, Christopher D. Brown, Marylyn D. Ritchie, Yan Shu, Katalin Susztak
Nature Genetics   ·   16 Jun 2022   ·   doi:10.1038/s41588-022-01097-w
TSABL: Trait Specific Annotation Based Locus predictor
TSABL: Trait Specific Annotation Based Locus predictor
Kim Lorenz, Christopher S. Thom, Sanjana Adurty, Benjamin F. Voight
BMC Genomics   ·   15 Jun 2022   ·   doi:10.1186/s12864-022-08654-x
Characterization of the genome and silk-gland transcriptomes of Darwin’s bark spider (Caerostris darwini)
Characterization of the genome and silk-gland transcriptomes of Darwin’s bark spider (Caerostris darwini)
Paul L. Babb, Matjaž Gregorič, Nicholas F. Lahens, David N. Nicholson, Cheryl Y. Hayashi, Linden Higgins, Matjaž Kuntner, Ingi Agnarsson, Benjamin F. Voight
PLOS ONE   ·   06 Jun 2022   ·   doi:10.1371/journal.pone.0268660
A multi-population phenome-wide association study of genetically-predicted height in the Million Veteran Program
A multi-population phenome-wide association study of genetically-predicted height in the Million Veteran Program
Sridharan Raghavan, Jie Huang, Catherine Tcheandjieu, Jennifer E. Huffman, Elizabeth Litkowski, ..., Kyong-Mi Chang, Kelly Cho, Christopher J. O’Donnell, Yan V. Sun, Themistocles L. Assimes
PLOS Genetics   ·   02 Jun 2022   ·   doi:10.1371/journal.pgen.1010193
A multiancestry genome-wide association study of unexplained chronic ALT elevation as a proxy for nonalcoholic fatty liver disease with histological and radiological validation
A multiancestry genome-wide association study of unexplained chronic ALT elevation as a proxy for nonalcoholic fatty liver disease with histological and radiological validation
Marijana Vujkovic, Shweta Ramdas, Kim M. Lorenz, Xiuqing Guo, Rebecca Darlay, ..., Jerome I. Rotter, Julie A. Lynch, Daniel J. Rader, Benjamin F. Voight, Kyong-Mi Chang
Nature Genetics   ·   01 Jun 2022   ·   doi:10.1038/s41588-022-01078-z
Multi‐phenotype analyses of hemostatic traits with cardiovascular events reveal novel genetic associations
Multi‐phenotype analyses of hemostatic traits with cardiovascular events reveal novel genetic associations
Gerard Temprano‐Sagrera, Colleen M. Sitlani, William P. Bone, Miguel Martin‐Bornez, Benjamin F. Voight, ..., Hugh S Markus, Joanna MM Howson, Yoichiro Kamatani, Stephanie Debette, Martin Dichgans
Journal of Thrombosis and Haemostasis   ·   01 Jun 2022   ·   doi:10.1111/jth.15698
A Phenome-Wide Association Study of genes associated with COVID-19 severity reveals shared genetics with complex diseases in the Million Veteran Program
A Phenome-Wide Association Study of genes associated with COVID-19 severity reveals shared genetics with complex diseases in the Million Veteran Program
Anurag Verma, Noah L. Tsao, Lauren O. Thomann, Yuk-Lam Ho, Sudha K. Iyengar, ..., Philip S. Tsao, J. Michael Gaziano, Christopher O’Donnell, Scott M. Damrauer, Katherine P. Liao
PLOS Genetics   ·   28 Apr 2022   ·   doi:10.1371/journal.pgen.1010113
Body mass index and adipose distribution have opposing genetic impacts on human blood traits
Body mass index and adipose distribution have opposing genetic impacts on human blood traits
Christopher S Thom, Madison B Wilken, Stella T Chou, Benjamin F Voight
eLife   ·   15 Feb 2022   ·   doi:10.7554/eLife.75317
Body mass index and adipose distribution have opposing genetic impacts on human blood traits
Body mass index and adipose distribution have opposing genetic impacts on human blood traits
Christopher S Thom, Madison B Wilken, Stella T Chou, Benjamin F Voight
eLife   ·   15 Feb 2022   ·   doi:10.7554/elife.75317
Separating the direct effects of traits on atherosclerotic cardiovascular disease from those mediated by type 2 diabetes
Separating the direct effects of traits on atherosclerotic cardiovascular disease from those mediated by type 2 diabetes
Venexia M. Walker, Marijana Vujkovic, Alice R. Carter, Neil M. Davies, Miriam S. Udler, Michael G. Levin, George Davey Smith, Benjamin F. Voight, Tom R. Gaunt, Scott M. Damrauer
Diabetologia   ·   07 Feb 2022   ·   doi:10.1007/s00125-022-05653-1
Multi-Trait Genome-Wide Association Study of Atherosclerosis Detects Novel Pleiotropic Loci
Multi-Trait Genome-Wide Association Study of Atherosclerosis Detects Novel Pleiotropic Loci
Tiffany R. Bellomo, William P. Bone, Brian Y. Chen, Katerina A. B. Gawronski, David Zhang, ..., Philip S. Tsao, Daniel J. Rader, Marylyn D. Ritchie, Scott M. Damrauer, Benjamin F. Voight
Frontiers in Genetics   ·   02 Feb 2022   ·   doi:10.3389/fgene.2021.787545

2021

Mendelian randomization analyses clarify the effects of height on cardiovascular diseases
Mendelian randomization analyses clarify the effects of height on cardiovascular diseases
Daniel Hui, Eric Sanford, Kimberly Lorenz, Scott M. Damrauer, Themistocles L. Assimes, Christopher S. Thom, Benjamin F. Voight
Cold Spring Harbor Laboratory   ·   17 Dec 2021   ·   doi:10.1101/2021.12.16.21267869
Cis-regulatory architecture of human ESC-derived hypothalamic neuron differentiation aids in variant-to-gene mapping of relevant complex traits
Cis-regulatory architecture of human ESC-derived hypothalamic neuron differentiation aids in variant-to-gene mapping of relevant complex traits
Matthew C. Pahl, Claudia A. Doege, Kenyaita M. Hodge, Sheridan H. Littleton, Michelle E. Leonard, ..., Andrew D. Wells, Benjamin F. Voight, Rudolph L. Leibel, Diana L. Cousminer, Struan F. A. Grant
Nature Communications   ·   19 Nov 2021   ·   doi:10.1038/s41467-021-27001-4
ColocQuiaL: A QTL-GWAS colocalization pipeline
ColocQuiaL: A QTL-GWAS colocalization pipeline
Brian Y. Chen, William P. Bone, Kimberly Lorenz, Michael Levin, Marylyn D. Ritchie, Benjamin F. Voight
Cold Spring Harbor Laboratory   ·   09 Nov 2021   ·   doi:10.1101/2021.11.05.21265991
Obesity and adiposity have opposing genetic impacts on human blood traits
Obesity and adiposity have opposing genetic impacts on human blood traits
Christopher S Thom, Madison B Wilken, Stella T Chou, Benjamin F Voight
Cold Spring Harbor Laboratory   ·   07 Nov 2021   ·   doi:10.1101/2021.11.05.467482
A Missense Variant in the IL-6 Receptor and Protection From Peripheral Artery Disease
A Missense Variant in the IL-6 Receptor and Protection From Peripheral Artery Disease
Michael G. Levin, Derek Klarin, Marios K. Georgakis, Julie Lynch, Katherine P. Liao, ..., Christopher J. O’Donnell, Kyong-Mi Chang, Themistocles L. Assimes, Philip S. Tsao, Scott M. Damrauer
Circulation Research   ·   29 Oct 2021   ·   doi:10.1161/CIRCRESAHA.121.319589
TSABL: Trait Specific Annotation Based Locus Predictor
TSABL: Trait Specific Annotation Based Locus Predictor
Kimberly Lorenz, Christopher S. Thom, Sanjana Adurty, Benjamin F. Voight
Cold Spring Harbor Laboratory   ·   29 Sep 2021   ·   doi:10.1101/2021.09.27.21264198
Evaluation of height as a disease risk factor through a phenome-wide association study of genetically-predicted height
Evaluation of height as a disease risk factor through a phenome-wide association study of genetically-predicted height
Sridharan Raghavan, Jie Huang, Catherine Tcheandjieu, Jennifer E. Huffman, Elizabeth Litkowski, ..., Kyong-Mi Chang, Kelly Cho, Christopher J. O’Donnell, Yan V. Sun, Themistocles L. Assimes
Cold Spring Harbor Laboratory   ·   30 Aug 2021   ·   doi:10.1101/2021.08.29.21262793
A single genetic locus controls both expression of DPEP1/CHMP1A and kidney disease development via ferroptosis
A single genetic locus controls both expression of DPEP1/CHMP1A and kidney disease development via ferroptosis
Yuting Guan, Xiujie Liang, Ziyuan Ma, Hailong Hu, Hongbo Liu, Zhen Miao, Andreas Linkermann, Jacklyn N. Hellwege, Benjamin F. Voight, Katalin Susztak
Nature Communications   ·   23 Aug 2021   ·   doi:10.1038/s41467-021-25377-x
Mapping the genetic architecture of human traits to cell types in the kidney identifies mechanisms of disease and potential treatments
Mapping the genetic architecture of human traits to cell types in the kidney identifies mechanisms of disease and potential treatments
Xin Sheng, Yuting Guan, Ziyuan Ma, Junnan Wu, Hongbo Liu, ..., Mingyao Li, Benjamin F. Voight, Thomas M. Coffman, Christopher D. Brown, Katalin Susztak
Nature Genetics   ·   12 Aug 2021   ·   doi:10.1038/s41588-021-00909-9
Separating the direct effects of risk factors for atherosclerotic cardiovascular disease from those mediated by type 2 diabetes
Separating the direct effects of risk factors for atherosclerotic cardiovascular disease from those mediated by type 2 diabetes
Venexia M Walker, Marijana Vujkovic, Alice R Carter, Neil M Davies, Miriam S Udler, Michael G Levin, George Davey Smith, Benjamin F Voight, Tom R Gaunt, Scott M Damrauer
Cold Spring Harbor Laboratory   ·   07 Aug 2021   ·   doi:10.1101/2021.08.05.21261658
Multi-ancestry Multivariate Genome-Wide Analysis Highlights the Role of Common Genetic Variation in Cardiac Structure, Function, and Heart Failure-related Traits
Multi-ancestry Multivariate Genome-Wide Analysis Highlights the Role of Common Genetic Variation in Cardiac Structure, Function, and Heart Failure-related Traits
Michael G. Levin, Noah L. Tsao, Tiffany R. Bellomo, William P. Bone, Krishna G. Aragam, ..., Sharlene M. Day, Patrick T. Ellinor, Kenneth B. Margulies, Benjamin F. Voight, Scott M. Damrauer
Cold Spring Harbor Laboratory   ·   05 Aug 2021   ·   doi:10.1101/2021.08.03.21261508
Prioritizing the Role of Major Lipoproteins and Subfractions as Risk Factors for Peripheral Artery Disease
Prioritizing the Role of Major Lipoproteins and Subfractions as Risk Factors for Peripheral Artery Disease
Michael G. Levin, Verena Zuber, Venexia M. Walker, Derek Klarin, Julie Lynch, ..., Philip S. Tsao, Benjamin F. Voight, Dipender Gill, Stephen Burgess, Scott M. Damrauer
Circulation   ·   03 Aug 2021   ·   doi:10.1161/CIRCULATIONAHA.121.053797
Projecting genetic associations through gene expression patterns highlights disease etiology and drug mechanisms
Projecting genetic associations through gene expression patterns highlights disease etiology and drug mechanisms
Milton Pividori, Sumei Lu, Binglan Li, Chun Su, Matthew E. Johnson, ..., Benjamin F. Voight, Carsten Skarke, Marylyn D. Ritchie, Struan F.A. Grant, Casey S. Greene
Cold Spring Harbor Laboratory   ·   06 Jul 2021   ·   doi:10.1101/2021.07.05.450786
Genetic Evidence for Repurposing of GLP1R (Glucagon‐Like Peptide‐1 Receptor) Agonists to Prevent Heart Failure
Genetic Evidence for Repurposing of GLP1R (Glucagon‐Like Peptide‐1 Receptor) Agonists to Prevent Heart Failure
Iyas Daghlas, Ville Karhunen, Devleena Ray, Verena Zuber, Stephen Burgess, ..., Emma H. Baker, Scott M. Damrauer, Joanna M. M. Howson, Marijana Vujkovic, Dipender Gill
Journal of the American Heart Association   ·   06 Jul 2021   ·   doi:10.1161/JAHA.120.020331
A unified framework identifies new links between plasma lipids and diseases from electronic medical records across large-scale cohorts
A unified framework identifies new links between plasma lipids and diseases from electronic medical records across large-scale cohorts
Yogasudha Veturi, Anastasia Lucas, Yuki Bradford, Daniel Hui, Scott Dudek, ..., Thomas J. Hoffmann, Neil Risch, Benjamin F. Voight, Daniel J. Rader, Marylyn D. Ritchie
Nature Genetics   ·   17 Jun 2021   ·   doi:10.1038/s41588-021-00879-y
Association Between Genetic Variation in Blood Pressure and Increased Lifetime Risk of Peripheral Artery Disease
Association Between Genetic Variation in Blood Pressure and Increased Lifetime Risk of Peripheral Artery Disease
Michael G. Levin, Derek Klarin, Venexia M. Walker, Dipender Gill, Julie Lynch, ..., Neil M. Davies, Philip S. Tsao, Kyong-Mi Chang, Benjamin F. Voight, Scott M. Damrauer
Arteriosclerosis, Thrombosis, and Vascular Biology   ·   01 Jun 2021   ·   doi:10.1161/ATVBAHA.120.315482
Multi-trait GWAS of atherosclerosis detects novel pleiotropic loci
Multi-trait GWAS of atherosclerosis detects novel pleiotropic loci
Tiffany R. Bellomo, William P. Bone, Brian Y. Chen, Katerina A. B. Gawronski, David Zhang, ..., Phil S. Tsao, Daniel J. Rader, Marylyn D. Ritchie, Benjamin F. Voight, Scott M. Damrauer
Cold Spring Harbor Laboratory   ·   23 May 2021   ·   doi:10.1101/2021.05.21.21257493
A Phenome-Wide Association Study of genes associated with COVID-19 severity reveals shared genetics with complex diseases in the Million Veteran Program
A Phenome-Wide Association Study of genes associated with COVID-19 severity reveals shared genetics with complex diseases in the Million Veteran Program
Anurag Verma, Noah Tsao, Lauren Thomann, Yuk-Lam Ho, Sudha Iyengar, ..., Philip S. Tsao, J. Michael Gaziano, Christopher O’Donnell, Scott Damrauer, Katherine Liao
Cold Spring Harbor Laboratory   ·   23 May 2021   ·   doi:10.1101/2021.05.18.21257396
Genetic analysis in European ancestry individuals identifies 517 loci associated with liver enzymes
Genetic analysis in European ancestry individuals identifies 517 loci associated with liver enzymes
Raha Pazoki, Marijana Vujkovic, Joshua Elliott, Evangelos Evangelou, Dipender Gill, ..., Shahpoor Shayan, Stacey B. Whitbourne, Jim L. Breeling, J. P. Casas Romero, Rachel B. Ramoni
Nature Communications   ·   10 May 2021   ·   doi:10.1038/s41467-021-22338-2
Multi-trait association studies discover pleiotropic loci between Alzheimer’s disease and cardiometabolic traits
Multi-trait association studies discover pleiotropic loci between Alzheimer’s disease and cardiometabolic traits
William P. Bone, Katherine M. Siewert, Anupama Jha, Derek Klarin, Scott M. Damrauer, Kyong-Mi Chang, Philip S. Tsao, Themistocles L. Assimes, Marylyn D. Ritchie, Benjamin F. Voight
Alzheimer's Research & Therapy   ·   04 Feb 2021   ·   doi:10.1186/s13195-021-00773-z
Genetics of Smoking and Risk of Atherosclerotic Cardiovascular Diseases
Genetics of Smoking and Risk of Atherosclerotic Cardiovascular Diseases
Michael G. Levin, Derek Klarin, Themistocles L. Assimes, Matthew S. Freiberg, Erik Ingelsson, ..., Daniel J. Rader, Philip S. Tsao, Kyong-Mi Chang, Benjamin F. Voight, Scott M. Damrauer
JAMA Network Open   ·   19 Jan 2021   ·   doi:10.1001/jamanetworkopen.2020.34461
Prioritizing the Role of Major Lipoproteins and Subfractions as Risk Factors for Peripheral Artery Disease
Prioritizing the Role of Major Lipoproteins and Subfractions as Risk Factors for Peripheral Artery Disease
Michael G. Levin, Verena Zuber, Venexia M. Walker, Derek Klarin, Julie Lynch, ..., Philip S. Tsao, Benjamin F. Voight, Dipender Gill, Stephen Burgess, Scott M. Damrauer
Cold Spring Harbor Laboratory   ·   15 Jan 2021   ·   doi:10.1101/2021.01.11.21249148
Genome-wide association study implicates novel loci and reveals candidate effector genes for longitudinal pediatric bone accrual
Genome-wide association study implicates novel loci and reveals candidate effector genes for longitudinal pediatric bone accrual
Diana L. Cousminer, Yadav Wagley, James A. Pippin, Ahmed Elhakeem, Gregory P. Way, ..., Benjamin F. Voight, Andrew D. Wells, Babette S. Zemel, Kurt D. Hankenson, Struan F. A. Grant
Genome Biology   ·   04 Jan 2021   ·   doi:10.1186/s13059-020-02207-9
A trans-ancestry genome-wide association study of unexplained chronic ALT elevation as a proxy for nonalcoholic fatty liver disease with histological and radiological validation
A trans-ancestry genome-wide association study of unexplained chronic ALT elevation as a proxy for nonalcoholic fatty liver disease with histological and radiological validation
Marijana Vujkovic, Shweta Ramdas, Kimberly M. Lorenz, Xiuqing Guo, Rebecca Darlay, ..., Jerome I. Rotter, Julie A. Lynch, Daniel J. Rader, Benjamin F. Voight, Kyong-Mi Chang
Cold Spring Harbor Laboratory   ·   02 Jan 2021   ·   doi:10.1101/2020.12.26.20248491

2020

Golden orb-weaving spider (<i>Trichonephila clavipes</i>) silk genes with sex-biased expression and atypical architectures
Golden orb-weaving spider (Trichonephila clavipes) silk genes with sex-biased expression and atypical architectures
Sandra M Correa-Garhwal, Paul L Babb, Benjamin F Voight, Cheryl Y Hayashi
G3 Genes|Genomes|Genetics   ·   22 Dec 2020   ·   doi:10.1093/G3JOURNAL/JKAA039
Genetic Predisposition to Coronary Artery Disease in Type 2 Diabetes Mellitus
Genetic Predisposition to Coronary Artery Disease in Type 2 Diabetes Mellitus
Natalie R. van Zuydam, Claes Ladenvall, Benjamin F. Voight, Rona J. Strawbridge, Juan Fernandez-Tajes, ..., Li-ming Gan, Everson Nogoceke, Piero Tortoli, Bernd Jablonka, Mary-Julia Brosnan
Circulation: Genomic and Precision Medicine   ·   01 Dec 2020   ·   doi:10.1161/CIRCGEN.119.002769
Mapping the genetic architecture of human traits to cell types in the kidney identifies mechanisms of disease and potential treatments
Mapping the genetic architecture of human traits to cell types in the kidney identifies mechanisms of disease and potential treatments
Xin Sheng, Ziyuan Ma, Junnan Wu, Hongbo Liu, Chengxiang Qiu, ..., Mingyao Li, Benjamin Voight, Thomas Coffman, Christopher D. Brown, Katalin Susztak
Cold Spring Harbor Laboratory   ·   10 Nov 2020   ·   doi:10.1101/2020.11.09.375592
Genetics of height and risk of atrial fibrillation: A Mendelian randomization study
Genetics of height and risk of atrial fibrillation: A Mendelian randomization study
Michael G. Levin, Renae Judy, Dipender Gill, Marijana Vujkovic, Shefali S. Verma, ..., Matthew C. Hyman, Saman Nazarian, Daniel J. Rader, Benjamin F. Voight, Scott M. Damrauer
PLOS Medicine   ·   08 Oct 2020   ·   doi:10.1371/journal.pmed.1003288
The relationship between circulating lipids and breast cancer risk: A Mendelian randomization study
The relationship between circulating lipids and breast cancer risk: A Mendelian randomization study
Kelsey E. Johnson, Katherine M. Siewert, Derek Klarin, Scott M. Damrauer, Kyong-Mi Chang, Philip S. Tsao, Themistocles L. Assimes, Kara N. Maxwell, Benjamin F. Voight
PLOS Medicine   ·   11 Sep 2020   ·   doi:10.1371/journal.pmed.1003302
Multi-trait association studies discover pleiotropic loci between Alzheimer’s disease and cardiometabolic traits
Multi-trait association studies discover pleiotropic loci between Alzheimer’s disease and cardiometabolic traits
William P. Bone, Katherine M. Siewert, Anupama Jha, Derek Klarin, Scott M. Damrauer, Kyong-Mi Chang, Philip S. Tsao, Themistocles L. Assimes, Marylyn D. Ritchie, Benjamin F. Voight
Cold Spring Harbor Laboratory   ·   01 Sep 2020   ·   doi:10.1101/2020.08.26.20179366
Validating a non-invasive, ALT-based non-alcoholic fatty liver phenotype in the million veteran program
Validating a non-invasive, ALT-based non-alcoholic fatty liver phenotype in the million veteran program
Marina Serper, Marijana Vujkovic, David E. Kaplan, Rotonya M. Carr, Kyung Min Lee, ..., Scott M. Damrauer, Julie A. Lynch, Danish Saleheen, Benjamin F. Voight, Kyong-Mi Chang
PLOS ONE   ·   25 Aug 2020   ·   doi:10.1371/journal.pone.0237430
Genetic Variation in Blood Pressure and Lifetime Risk of Peripheral Artery Disease: A Mendelian Randomization Study
Genetic Variation in Blood Pressure and Lifetime Risk of Peripheral Artery Disease: A Mendelian Randomization Study
Michael G. Levin, Derek Klarin, Venexia M. Walker, Dipender Gill, Julie Lynch, ..., Neil M. Davies, Philip S. Tsao, Kyong-Mi Chang, Benjamin F. Voight, Scott M. Damrauer
Cold Spring Harbor Laboratory   ·   25 Aug 2020   ·   doi:10.1101/2020.08.23.20180240
Genetic determinants of increased body mass index mediate the effect of smoking on increased risk for type 2 diabetes but not coronary artery disease
Genetic determinants of increased body mass index mediate the effect of smoking on increased risk for type 2 diabetes but not coronary artery disease
Christopher S Thom, Zhuoran Ding, Michael G Levin, Scott M Damrauer, Kyung Min Lee, ..., Themistocles L Assimes, Yan V Sun, Christopher J O’Donnell, Marijana Vujkovic, Benjamin F Voight
Human Molecular Genetics   ·   24 Aug 2020   ·   doi:10.1093/hmg/ddaa193
Type 1 diabetes in Africa: an immunogenetic study in the Amhara of North-West Ethiopia
Type 1 diabetes in Africa: an immunogenetic study in the Amhara of North-West Ethiopia
Shitaye A. Balcha, Abayneh G. Demisse, Rajashree Mishra, Tanwi Vartak, Diana L. Cousminer, ..., Alistair J. K. Williams, Struan F. A. Grant, R. David Leslie, David I. W. Phillips, Elisabeth R. Trimble
Diabetologia   ·   23 Jul 2020   ·   doi:10.1007/s00125-020-05229-x
Cis-regulatory architecture of human ESC-derived hypothalamic neuron differentiation aids in variant-to-gene mapping of relevant complex traits
Cis-regulatory architecture of human ESC-derived hypothalamic neuron differentiation aids in variant-to-gene mapping of relevant complex traits
Matthew C. Pahl, Claudia A. Doege, Kenyaita M. Hodge, Sheridan H. Littleton, Michelle E. Leonard, ..., Andrew D. Wells, Benjamin F. Voight, Rudolph L. Leibel, Diana L. Cousminer, Struan F.A. Grant
Cold Spring Harbor Laboratory   ·   06 Jul 2020   ·   doi:10.1101/2020.07.06.146951
Discovery of 318 new risk loci for type 2 diabetes and related vascular outcomes among 1.4 million participants in a multi-ancestry meta-analysis
Discovery of 318 new risk loci for type 2 diabetes and related vascular outcomes among 1.4 million participants in a multi-ancestry meta-analysis
Marijana Vujkovic, Jacob M. Keaton, Julie A. Lynch, Donald R. Miller, Jin Zhou, ..., J. Michael Gaziano, Sumitra Muralidhar, Kyong-Mi Chang, Benjamin F. Voight, Danish Saleheen
Nature Genetics   ·   15 Jun 2020   ·   doi:10.1038/s41588-020-0637-y
Genetically Determined Birthweight Associates With Atrial Fibrillation
Genetically Determined Birthweight Associates With Atrial Fibrillation
Rachel L. Kember, Michael G. Levin, Diana L. Cousminer, Noah Tsao, Renae Judy, ..., Shana E. McCormack, Struan F.A. Grant, Daniel J. Rader, Benjamin F. Voight, Scott M. Damrauer
Circulation: Genomic and Precision Medicine   ·   01 Jun 2020   ·   doi:10.1161/CIRCGEN.119.002553
Identifying non-identical-by-descent rare variants in population-scale whole genome sequencing data
Identifying non-identical-by-descent rare variants in population-scale whole genome sequencing data
Kelsey E. Johnson, Benjamin F. Voight
Cold Spring Harbor Laboratory   ·   28 May 2020   ·   doi:10.1101/2020.05.26.117358
Tropomyosin 1 genetically constrains in vitro hematopoiesis
Tropomyosin 1 genetically constrains in vitro hematopoiesis
Christopher Stephen Thom, Chintan D Jobaliya, Kimberly Lorenz, Jean Ann Maguire, Alyssa Gagne, Paul Gadue, Deborah L French, Benjamin Franklin Voight
BMC Biology   ·   14 May 2020   ·   doi:10.1186/s12915-020-00783-7
Cross-trait analyses with migraine reveal widespread pleiotropy and suggest a vascular component to migraine headache
Cross-trait analyses with migraine reveal widespread pleiotropy and suggest a vascular component to migraine headache
Katherine M Siewert, Derek Klarin, Scott M Damrauer, Kyong-Mi Chang, Philip S Tsao, ..., Benjamin M Neale, Jes Olesen, Daniel I Chasman, Dale R Nyholt, Aarno Palotie
International Journal of Epidemiology   ·   19 Apr 2020   ·   doi:10.1093/IJE/DYAA050
A missense variant in Mitochondrial Amidoxime Reducing Component 1 gene and protection against liver disease
A missense variant in Mitochondrial Amidoxime Reducing Component 1 gene and protection against liver disease
Connor A. Emdin, Mary E. Haas, Amit V. Khera, Krishna Aragam, Mark Chaffin, ..., Craig Hanis, Mark Daly, Joshua Denny, Stacey Gabriel, Sekar Kathiresan
PLOS Genetics   ·   13 Apr 2020   ·   doi:10.1371/journal.pgen.1008629
Genetics of Smoking and Risk of Atherosclerotic Cardiovascular Diseases: A Mendelian Randomization Study
Genetics of Smoking and Risk of Atherosclerotic Cardiovascular Diseases: A Mendelian Randomization Study
Michael G. Levin, Derek Klarin, Themistocles L. Assimes, Matthew S. Freiberg, Erik Ingelsson, ..., Daniel J. Rader, Philip S. Tsao, Kyong-Mi Chang, Benjamin F. Voight, Scott M. Damrauer
Cold Spring Harbor Laboratory   ·   08 Apr 2020   ·   doi:10.1101/2020.04.07.20053447
Genome-wide association study implicates novel loci and reveals candidate effector genes for longitudinal pediatric bone accrual through variant-to-gene mapping
Genome-wide association study implicates novel loci and reveals candidate effector genes for longitudinal pediatric bone accrual through variant-to-gene mapping
Diana L. Cousminer, Yadav Wagley, James A. Pippin, Ahmed Elhakeem, Gregory P. Way, ..., Benjamin F. Voight, Andrew D. Wells, Babette S. Zemel, Kurt Hankenson, Struan F. A. Grant
Cold Spring Harbor Laboratory   ·   20 Feb 2020   ·   doi:10.1101/2020.02.17.20024133
Genetically determined body mass index mediates the effect of smoking on type 2 diabetes risk, but not coronary artery disease risk
Genetically determined body mass index mediates the effect of smoking on type 2 diabetes risk, but not coronary artery disease risk
Christopher S Thom, Zhuoran Ding, Michael G Levin, Scott M Damrauer, Benjamin F Voight
Cold Spring Harbor Laboratory   ·   03 Feb 2020   ·   doi:10.1101/2020.01.30.20019737

2019

Genetics of Height and Risk of Atrial Fibrillation: A Mendelian Randomization Study
Genetics of Height and Risk of Atrial Fibrillation: A Mendelian Randomization Study
Michael G. Levin, Renae Judy, Dipender Gill, Marijana Vujkovic, Matthew C. Hyman, Saman Nazarian, Daniel J. Rader, Benjamin F. Voight, Scott M. Damrauer
Cold Spring Harbor Laboratory   ·   30 Dec 2019   ·   doi:10.1101/2019.12.23.19015743
Genetic Discrimination Between LADA and Childhood-Onset Type 1 Diabetes Within the MHC
Genetic Discrimination Between LADA and Childhood-Onset Type 1 Diabetes Within the MHC
Rajashree Mishra, Mikael Åkerlund, Diana L. Cousminer, Emma Ahlqvist, Jonathan P. Bradfield, ..., Stanley Schwartz, Bernhard O. Boehm, Leif Groop, Richard David Leslie, Struan F.A. Grant
Diabetes Care   ·   16 Dec 2019   ·   doi:10.2337/dc19-0986
Discovery of 318 novel loci for type-2 diabetes and related micro- and macrovascular outcomes among 1.4 million participants in a multi-ethnic meta-analysis
Discovery of 318 novel loci for type-2 diabetes and related micro- and macrovascular outcomes among 1.4 million participants in a multi-ethnic meta-analysis
Marijana Vujkovic, Jacob M. Keaton, Julie A. Lynch, Donald R. Miller, Jin Zhou, ..., Christopher J. O’Donnell, Philip S. Tsao, Kyong-Mi Chang, Benjamin F. Voight, Danish Saleheen
Cold Spring Harbor Laboratory   ·   25 Nov 2019   ·   doi:10.1101/19012690
Natural human genetic variation determines basal and inducible expression of
            <i>PM20D1</i>
            , an obesity-associated gene
Natural human genetic variation determines basal and inducible expression of PM20D1 , an obesity-associated gene
Kiara K. Benson, Wenxiang Hu, Angela H. Weller, Alexis H. Bennett, Eric R. Chen, ..., William P. Bone, Lin Wang, Joshua D. Rabinowitz, Benjamin F. Voight, Raymond E. Soccio
Proceedings of the National Academy of Sciences   ·   28 Oct 2019   ·   doi:10.1073/pnas.1913199116
Assessing a causal relationship between circulating lipids and breast cancer risk: Mendelian randomization study
Assessing a causal relationship between circulating lipids and breast cancer risk: Mendelian randomization study
Kelsey E. Johnson, Katherine M. Siewert, Derek Klarin, Scott M. Damrauer, Kyong-Mi Chang, Philip S. Tsao, Themistocles L. Assimes, Kara N. Maxwell, Benjamin F. Voight
Cold Spring Harbor Laboratory   ·   06 Oct 2019   ·   doi:10.1101/794594
Projected Prevalence of Actionable Pharmacogenetic Variants and Level A Drugs Prescribed Among US Veterans Health Administration Pharmacy Users
Projected Prevalence of Actionable Pharmacogenetic Variants and Level A Drugs Prescribed Among US Veterans Health Administration Pharmacy Users
Catherine Chanfreau-Coffinier, Leland E. Hull, Julie A. Lynch, Scott L. DuVall, Scott M. Damrauer, ..., Benjamin F. Voight, Michael E. Matheny, David W. Oslin, Michael S. Icardi, Sony Tuteja
JAMA Network Open   ·   07 Jun 2019   ·   doi:10.1001/jamanetworkopen.2019.5345
Evaluating the contribution of cell-type specific alternative splicing to variation in lipid levels
Evaluating the contribution of cell-type specific alternative splicing to variation in lipid levels
K.A.B. Gawronski, W. Bone, Y. Park, E. Pashos, X. Wang, W. Yang, D. Rader, K. Musunuru, B. Voight, C. Brown
Cold Spring Harbor Laboratory   ·   04 Jun 2019   ·   doi:10.1101/659326
<i>Tropomyosin 1</i> genetically constrains <i>in vitro</i> hematopoiesis
Tropomyosin 1 genetically constrains in vitro hematopoiesis
CS Thom, CD Jobaliya, K Lorenz, JA Maguire, A Gagne, P Gadue, DL French, BF Voight
Cold Spring Harbor Laboratory   ·   08 May 2019   ·   doi:10.1101/631895
Postmenopausal osteoporotic fracture-associated COLIA1 variant impacts bone accretion in girls
Postmenopausal osteoporotic fracture-associated COLIA1 variant impacts bone accretion in girls
Diana L. Cousminer, Shana E. McCormack, Jonathan A. Mitchell, Alessandra Chesi, Joseph M. Kindler, ..., John A. Shepherd, Sharon E. Oberfield, Vicente Gilsanz, Babette S. Zemel, Struan F.A. Grant
Bone   ·   01 Apr 2019   ·   doi:10.1016/j.bone.2019.01.026
Signals of Variation in Human Mutation Rate at Multiple Levels of Sequence Context
Signals of Variation in Human Mutation Rate at Multiple Levels of Sequence Context
Rachael C Aikens, Kelsey E Johnson, Benjamin F Voight
Molecular Biology and Evolution   ·   07 Feb 2019   ·   doi:10.1093/molbev/msz023
Keen on the tenure track job, are you? Know these things, you should
Keen on the tenure track job, are you? Know these things, you should
Benjamin F. Voight
Genome Biology   ·   07 Jan 2019   ·   doi:10.1186/s13059-018-1617-8

2018

BetaScan2: Standardized statistics to detect balancing selection utilizing substitution data:
BetaScan2: Standardized statistics to detect balancing selection utilizing substitution data:
Katherine M Siewert, Benjamin F Voight
Cold Spring Harbor Laboratory   ·   17 Dec 2018   ·   doi:10.1101/497255
Bivariate Genome-Wide Association Scan Identifies 6 Novel Loci Associated With Lipid Levels and Coronary Artery Disease
Bivariate Genome-Wide Association Scan Identifies 6 Novel Loci Associated With Lipid Levels and Coronary Artery Disease
Katherine M. Siewert, Benjamin F. Voight
Circulation: Genomic and Precision Medicine   ·   01 Dec 2018   ·   doi:10.1161/CIRCGEN.118.002239
First Genome-Wide Association Study of Latent Autoimmune Diabetes in Adults Reveals Novel Insights Linking Immune and Metabolic Diabetes
First Genome-Wide Association Study of Latent Autoimmune Diabetes in Adults Reveals Novel Insights Linking Immune and Metabolic Diabetes
Diana L. Cousminer, Emma Ahlqvist, Rajashree Mishra, Mette K. Andersen, Alessandra Chesi, ..., Joan M. Lappe, John A. Shepherd, Sharon E. Oberfield, Vicente Gilsanz, Babette S. Zemel
Diabetes Care   ·   15 Oct 2018   ·   doi:10.2337/dc18-1032
Signals of variation in human mutation rate at multiple levels of sequence context
Signals of variation in human mutation rate at multiple levels of sequence context
Rachael C. Aikens, Kelsey E. Johnson, Benjamin F. Voight
Cold Spring Harbor Laboratory   ·   04 Aug 2018   ·   doi:10.1101/385096
Multiplexed Targeted Resequencing Identifies Coding and Regulatory Variation Underlying Phenotypic Extremes of High-Density Lipoprotein Cholesterol in Humans
Multiplexed Targeted Resequencing Identifies Coding and Regulatory Variation Underlying Phenotypic Extremes of High-Density Lipoprotein Cholesterol in Humans
Sumeet A. Khetarpal, Paul L. Babb, Wei Zhao, William F. Hancock-Cerutti, Christopher D. Brown, Daniel J. Rader, Benjamin F. Voight
Circulation: Genomic and Precision Medicine   ·   01 Jul 2018   ·   doi:10.1161/CIRCGEN.117.002070
Dissecting an adiposity locus with an arsenal of genomics
Dissecting an adiposity locus with an arsenal of genomics
Kim Lorenz, Benjamin F. Voight
Genome Biology   ·   07 Jun 2018   ·   doi:10.1186/s13059-018-1460-y
Bivariate GWAS scan identifies six novel loci associated with lipid levels and coronary artery disease
Bivariate GWAS scan identifies six novel loci associated with lipid levels and coronary artery disease
Katherine M. Siewert, Benjamin F. Voight
Cold Spring Harbor Laboratory   ·   11 May 2018   ·   doi:10.1101/319848
Patterns of shared signatures of recent positive selection across human populations
Patterns of shared signatures of recent positive selection across human populations
Kelsey Elizabeth Johnson, Benjamin F. Voight
Nature Ecology & Evolution   ·   19 Feb 2018   ·   doi:10.1038/s41559-018-0478-6
Erratum: Sequence data and association statistics from 12,940 type 2 diabetes cases and controls
Erratum: Sequence data and association statistics from 12,940 type 2 diabetes cases and controls
Jason Flannick, Christian Fuchsberger, Anubha Mahajan, Tanya M. Teslovich, Vineeta Agarwala, ..., David Altshuler, Noël P. Burtt, Jose C. Florez, Michael Boehnke, Mark I. McCarthy
Scientific Data   ·   23 Jan 2018   ·   doi:10.1038/sdata.2018.2

2017

Sequence data and association statistics from 12,940 type 2 diabetes cases and controls
Sequence data and association statistics from 12,940 type 2 diabetes cases and controls
Jason Flannick, Christian Fuchsberger, Anubha Mahajan, Tanya M. Teslovich, Vineeta Agarwala, ..., David Altshuler, Noël P. Burtt, Jose C. Florez, Michael Boehnke, Mark I. McCarthy
Scientific Data   ·   19 Dec 2017   ·   doi:10.1038/sdata.2017.179
Multiplexed targeted resequencing identifies coding and regulatory variation underlying phenotypic extremes of HDL-cholesterol in humans
Multiplexed targeted resequencing identifies coding and regulatory variation underlying phenotypic extremes of HDL-cholesterol in humans
Sumeet A. Khetarpal, Paul L. Babb, Wei Zhao, William F. Hancock-Cerutti, Christopher D. Brown, Daniel J. Rader, Benjamin F. Voight
Cold Spring Harbor Laboratory   ·   18 Dec 2017   ·   doi:10.1101/235887
Genetically Determined Later Puberty Impacts Lowered Bone Mineral Density in Childhood and Adulthood
Genetically Determined Later Puberty Impacts Lowered Bone Mineral Density in Childhood and Adulthood
Diana L Cousminer, Jonathan A Mitchell, Alessandra Chesi, Sani M Roy, Heidi J Kalkwarf, ..., Andrea Kelly, Shana E McCormack, Benjamin F Voight, Babette S Zemel, Struan FA Grant
Journal of Bone and Mineral Research   ·   17 Nov 2017   ·   doi:10.1002/jbmr.3320
Identification of new susceptibility loci for type 2 diabetes and shared etiological pathways with coronary heart disease
Identification of new susceptibility loci for type 2 diabetes and shared etiological pathways with coronary heart disease
Wei Zhao, Asif Rasheed, Emmi Tikkanen, Jung-Jin Lee, Adam S Butterworth, ..., Veikko Salomaa, Daniel J Rader, John Danesh, Benjamin F Voight, Danish Saleheen
Nature Genetics   ·   04 Sep 2017   ·   doi:10.1038/ng.3943
Detecting Long-Term Balancing Selection Using Allele Frequency Correlation
Detecting Long-Term Balancing Selection Using Allele Frequency Correlation
Katherine M. Siewert, Benjamin F. Voight
Molecular Biology and Evolution   ·   21 Jul 2017   ·   doi:10.1093/molbev/msx209
An Expanded Genome-Wide Association Study of Type 2 Diabetes in Europeans
An Expanded Genome-Wide Association Study of Type 2 Diabetes in Europeans
Robert A. Scott, Laura J. Scott, Reedik Mägi, Letizia Marullo, Kyle J. Gaulton, ..., Josée Dupuis, Andrew P. Morris, Michael Boehnke, Mark I. McCarthy, Inga Prokopenko
Diabetes   ·   31 May 2017   ·   doi:10.2337/db16-1253
Gene Set Enrichment Analyses: lessons learned from the heart failure phenotype
Gene Set Enrichment Analyses: lessons learned from the heart failure phenotype
Vinicius Tragante, Johannes M. I. H. Gho, Janine F. Felix, Ramachandran S. Vasan, Nicholas L. Smith, Benjamin F. Voight, Colin Palmer, Pim van der Harst, Jason H. Moore, Folkert W. Asselbergs
BioData Mining   ·   26 May 2017   ·   doi:10.1186/s13040-017-0137-5
The Nephila clavipes genome highlights the diversity of spider silk genes and their complex expression
The Nephila clavipes genome highlights the diversity of spider silk genes and their complex expression
Paul L Babb, Nicholas F Lahens, Sandra M Correa-Garhwal, David N Nicholson, Eun Ji Kim, ..., Matjaž Kuntner, Linden Higgins, Cheryl Y Hayashi, Ingi Agnarsson, Benjamin F Voight
Nature Genetics   ·   01 May 2017   ·   doi:10.1038/ng.3852
Relative contribution of type 1 and type 2 diabetes loci to the genetic etiology of adult-onset, non-insulin-requiring autoimmune diabetes
Relative contribution of type 1 and type 2 diabetes loci to the genetic etiology of adult-onset, non-insulin-requiring autoimmune diabetes
Rajashree Mishra, Alessandra Chesi, Diana L. Cousminer, Mohammad I. Hawa, Jonathan P. Bradfield, ..., Benjamin F. Voight, Stanley Schwartz, Bernhard O. Boehm, Richard David Leslie, Struan F. A. Grant
BMC Medicine   ·   25 Apr 2017   ·   doi:10.1186/s12916-017-0846-0
Large-Scale trans -eQTLs Affect Hundreds of Transcripts and Mediate Patterns of Transcriptional Co-regulation
Large-Scale trans -eQTLs Affect Hundreds of Transcripts and Mediate Patterns of Transcriptional Co-regulation
Boel Brynedal, JinMyung Choi, Towfique Raj, Robert Bjornson, Barbara E. Stranger, Benjamin M. Neale, Benjamin F. Voight, Chris Cotsapas
The American Journal of Human Genetics   ·   01 Apr 2017   ·   doi:10.1016/j.ajhg.2017.02.004
Detecting Long-term Balancing Selection using Allele Frequency Correlation
Detecting Long-term Balancing Selection using Allele Frequency Correlation
Katherine M. Siewert, Benjamin F. Voight
Cold Spring Harbor Laboratory   ·   01 Mar 2017   ·   doi:10.1101/112870
Patterns of shared signatures of recent positive selection across human populations
Patterns of shared signatures of recent positive selection across human populations
Kelsey Elizabeth Johnson, Benjamin F. Voight
Cold Spring Harbor Laboratory   ·   17 Feb 2017   ·   doi:10.1101/109371
De novo mutational profile in RB1 clarified using a mutation rate modeling algorithm
De novo mutational profile in RB1 clarified using a mutation rate modeling algorithm
Varun Aggarwala, Arupa Ganguly, Benjamin F. Voight
BMC Genomics   ·   14 Feb 2017   ·   doi:10.1186/s12864-017-3522-z

2016

Serum calcium and risk of migraine: a Mendelian randomization study
Serum calcium and risk of migraine: a Mendelian randomization study
Peter Yin, Verneri Anttila, Katherine M. Siewert, Aarno Palotie, George Davey Smith, Benjamin F. Voight
Human Molecular Genetics   ·   26 Dec 2016   ·   doi:10.1093/hmg/ddw416
Type 2 Diabetes Genes Gleaned by Making a β-Cell Screen Routine
Type 2 Diabetes Genes Gleaned by Making a β-Cell Screen Routine
Benjamin F. Voight, Struan F.A. Grant
Diabetes   ·   12 Nov 2016   ·   doi:10.2337/dbi16-0054
Assessing the general population frequency of rare coding variants in the EXT1 and EXT2 genes previously implicated in hereditary multiple exostoses
Assessing the general population frequency of rare coding variants in the EXT1 and EXT2 genes previously implicated in hereditary multiple exostoses
Diana L. Cousminer, Alexandre Arkader, Benjamin F. Voight, Maurizio Pacifici, Struan F.A. Grant
Bone   ·   01 Nov 2016   ·   doi:10.1016/j.bone.2016.09.005
Systolic Blood Pressure and Risk of Type 2 Diabetes: A Mendelian Randomization Study
Systolic Blood Pressure and Risk of Type 2 Diabetes: A Mendelian Randomization Study
Rachael C. Aikens, Wei Zhao, Danish Saleheen, Muredach P. Reilly, Stephen E. Epstein, Emmi Tikkanen, Veikko Salomaa, Benjamin F. Voight
Diabetes   ·   04 Oct 2016   ·   doi:10.2337/db16-0868
The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals
The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals
Georg B Ehret, Teresa Ferreira, Daniel I Chasman, Anne U Jackson, Ellen M Schmidt, ..., Aravinda Chakravarti, Panos Deloukas, Andrew P Morris, Christopher Newton-Cheh, Patricia B Munroe
Nature Genetics   ·   12 Sep 2016   ·   doi:10.1038/ng.3667
Disentangling the Causal Association of Plasma Lipid Traits and Type 2 Diabetes Using Human Genetics
Disentangling the Causal Association of Plasma Lipid Traits and Type 2 Diabetes Using Human Genetics
Danish Saleheen, Daniel J. Rader, Benjamin F. Voight
JAMA Cardiology   ·   01 Sep 2016   ·   doi:10.1001/jamacardio.2016.2298
The genetic architecture of type 2 diabetes
The genetic architecture of type 2 diabetes
Christian Fuchsberger, Jason Flannick, Tanya M. Teslovich, Anubha Mahajan, Vineeta Agarwala, ..., Andrew P. Morris, Hyun Min Kang, Michael Boehnke, David Altshuler, Mark I. McCarthy
Nature   ·   11 Jul 2016   ·   doi:10.1038/nature18642
Pathway and network-based strategies to translate genetic discoveries into effective therapies
Pathway and network-based strategies to translate genetic discoveries into effective therapies
Casey S. Greene, Benjamin F. Voight
Human Molecular Genetics   ·   23 Jun 2016   ·   doi:10.1093/hmg/ddw160
Large-scale <i>trans</i>-eQTLs affect hundreds of transcripts and mediate patterns of transcriptional co-regulation Short: <i>trans</i>-eQTLs reveal patterns of transcriptional co-regulation
Large-scale trans-eQTLs affect hundreds of transcripts and mediate patterns of transcriptional co-regulation Short: trans-eQTLs reveal patterns of transcriptional co-regulation
Boel Brynedal, JinMyung Choi, Towfique Raj, Robert Bjornson, Barbara E Stranger, Benjamin M Neale, Benjamin F Voight, Chris Cotsapas
Cold Spring Harbor Laboratory   ·   31 May 2016   ·   doi:10.1101/056283
An expanded sequence context model broadly explains variability in polymorphism levels across the human genome
An expanded sequence context model broadly explains variability in polymorphism levels across the human genome
Varun Aggarwala, Benjamin F Voight
Nature Genetics   ·   15 Feb 2016   ·   doi:10.1038/ng.3511
Human genetics shines a light on ischaemic stroke
Human genetics shines a light on ischaemic stroke
Benjamin F Voight, Daniel J Rader
The Lancet Neurology   ·   01 Feb 2016   ·   doi:10.1016/S1474-4422(15)00400-7
Causal Assessment of Serum Urate Levels in Cardiometabolic Diseases Through a Mendelian Randomization Study
Causal Assessment of Serum Urate Levels in Cardiometabolic Diseases Through a Mendelian Randomization Study
Tanya Keenan, Wei Zhao, Asif Rasheed, Weang K. Ho, Rainer Malik, ..., Muredach P. Reilly, John Danesh, Daniel J. Rader, Benjamin F. Voight, Danish Saleheen
Journal of the American College of Cardiology   ·   01 Feb 2016   ·   doi:10.1016/j.jacc.2015.10.086
Causal Inference in Medicine via Mendelian Randomization
Causal Inference in Medicine via Mendelian Randomization
Timothy M. Frayling, Benjamin F. Voight
The Genetics of Type 2 Diabetes and Related Traits   ·   01 Jan 2016   ·   doi:10.1007/978-3-319-01574-3_24

2015

Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci
Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci
Kyle J Gaulton, Teresa Ferreira, Yeji Lee, Anne Raimondo, Reedik Mägi, ..., David Altshuler, Michael Boehnke, Tanya M Teslovich, Mark I McCarthy, Andrew P Morris
Nature Genetics   ·   09 Nov 2015   ·   doi:10.1038/ng.3437
Genetic variants primarily associated with type 2 diabetes are related to coronary artery disease risk
Genetic variants primarily associated with type 2 diabetes are related to coronary artery disease risk
Henning Jansen, Christina Loley, Wolfgang Lieb, Michael J. Pencina, Christopher P. Nelson, ..., Inke R. König, Ramachandran S. Vasan, Jeanette Erdmann, Nilesh J. Samani, Heribert Schunkert
Atherosclerosis   ·   01 Aug 2015   ·   doi:10.1016/j.atherosclerosis.2015.05.033
Genetic Variation Determines PPARγ Function and Anti-diabetic Drug Response In Vivo
Genetic Variation Determines PPARγ Function and Anti-diabetic Drug Response In Vivo
Raymond E. Soccio, Eric R. Chen, Satyajit R. Rajapurkar, Pegah Safabakhsh, Jill M. Marinis, ..., David J. Steger, Ying Wu, Mete Civelek, Benjamin F. Voight, Mitchell A. Lazar
Cell   ·   01 Jul 2015   ·   doi:10.1016/j.cell.2015.06.025

2014

MeRP: a high-throughput pipeline for Mendelian randomization analysis
MeRP: a high-throughput pipeline for Mendelian randomization analysis
Peter Yin, Benjamin F. Voight
Bioinformatics   ·   10 Nov 2014   ·   doi:10.1093/bioinformatics/btu742
MR_predictor: a simulation engine for Mendelian Randomization studies
MR_predictor: a simulation engine for Mendelian Randomization studies
Benjamin F. Voight
Bioinformatics   ·   26 Aug 2014   ·   doi:10.1093/bioinformatics/btu564
Pleiotropic genes for metabolic syndrome and inflammation
Pleiotropic genes for metabolic syndrome and inflammation
Aldi T. Kraja, Daniel I. Chasman, Kari E. North, Alexander P. Reiner, Lisa R. Yanek, ..., Emelia J. Benjamin, Behrooz Z. Alizadeh, Inga Prokopenko, James B. Meigs, Ingrid B. Borecki
Molecular Genetics and Metabolism   ·   01 Aug 2014   ·   doi:10.1016/j.ymgme.2014.04.007
A Central Role for GRB10 in Regulation of Islet Function in Man
A Central Role for GRB10 in Regulation of Islet Function in Man
Inga Prokopenko, Wenny Poon, Reedik Mägi, Rashmi Prasad B, S. Albert Salehi, ..., Alan R. Shuldiner, Kristi D. Silver, Markku Laakso, Leif Groop, Valeriya Lyssenko
PLoS Genetics   ·   03 Apr 2014   ·   doi:10.1371/journal.pgen.1004235
Guidelines for investigating causality of sequence variants in human disease
Guidelines for investigating causality of sequence variants in human disease
D. G. MacArthur, T. A. Manolio, D. P. Dimmock, H. L. Rehm, J. Shendure, ..., S. R. Sunyaev, D. Valle, B. F. Voight, W. Winckler, C. Gunter
Nature   ·   01 Apr 2014   ·   doi:10.1038/nature13127
<i>SORT</i>
            ing Out That Pesky Cholesterol
SORT ing Out That Pesky Cholesterol
Benjamin F. Voight
Science Translational Medicine   ·   05 Mar 2014   ·   doi:10.1126/scitranslmed.3008715
Loss-of-function mutations in SLC30A8 protect against type 2 diabetes
Loss-of-function mutations in SLC30A8 protect against type 2 diabetes
Jason Flannick, Gudmar Thorleifsson, Nicola L Beer, Suzanne B R Jacobs, Niels Grarup, ..., Oluf Pedersen, Leif Groop, David R Cox, Kari Stefansson, David Altshuler
Nature Genetics   ·   02 Mar 2014   ·   doi:10.1038/ng.2915
Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility
Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility
Anubha Mahajan, Min Jin Go, Weihua Zhang, Jennifer E Below, Kyle J Gaulton, ..., Esteban J Parra, John C Chambers, E Shyong Tai, Mark I McCarthy, Andrew P Morris
Nature Genetics   ·   09 Feb 2014   ·   doi:10.1038/ng.2897
A Metabolic Relic
A Metabolic Relic
Benjamin F. Voight
Science Translational Medicine   ·   22 Jan 2014   ·   doi:10.1126/scitranslmed.3008436

2013

Right Place, Right Time
Right Place, Right Time
Benjamin F. Voight
Science Translational Medicine   ·   04 Dec 2013   ·   doi:10.1126/scitranslmed.3008007
Thinking Before We Act
Thinking Before We Act
Benjamin F. Voight
Science Translational Medicine   ·   23 Oct 2013   ·   doi:10.1126/scitranslmed.3007770
Discovery and refinement of loci associated with lipid levels
Discovery and refinement of loci associated with lipid levels
[no author info]
Nature Genetics   ·   06 Oct 2013   ·   doi:10.1038/ng.2797
Common variants associated with plasma triglycerides and risk for coronary artery disease
Common variants associated with plasma triglycerides and risk for coronary artery disease
Ron Do, Cristen J Willer, Ellen M Schmidt, Sebanti Sengupta, Chi Gao, ..., Erik Ingelsson, Goncalo R Abecasis, Mark J Daly, Benjamin M Neale, Sekar Kathiresan
Nature Genetics   ·   06 Oct 2013   ·   doi:10.1038/ng.2795
Ironing Out Parkinson’s Disease
Ironing Out Parkinson’s Disease
Benjamin F. Voight
Science Translational Medicine   ·   31 Jul 2013   ·   doi:10.1126/scitranslmed.3007047
<i>RA-</i>
            cing Toward Drugs from a Genetics Starting Line
RA- cing Toward Drugs from a Genetics Starting Line
Benjamin F. Voight
Science Translational Medicine   ·   19 Jun 2013   ·   doi:10.1126/scitranslmed.3006750
From Mouse to Human: Evolutionary Genomics Analysis of Human Orthologs of Essential Genes
From Mouse to Human: Evolutionary Genomics Analysis of Human Orthologs of Essential Genes
Benjamin Georgi, Benjamin F. Voight, Maja Bućan
PLoS Genetics   ·   09 May 2013   ·   doi:10.1371/journal.pgen.1003484
Eavesdropping on Communications Between Liver and β Cells
Eavesdropping on Communications Between Liver and β Cells
Benjamin F. Voight
Science Translational Medicine   ·   08 May 2013   ·   doi:10.1126/scitranslmed.3006452
Accessing the Inaccessible Genome
Accessing the Inaccessible Genome
Benjamin F. Voight
Science Translational Medicine   ·   03 Apr 2013   ·   doi:10.1126/scitranslmed.3006206

2012

Large-scale association analysis identifies new risk loci for coronary artery disease
Large-scale association analysis identifies new risk loci for coronary artery disease
Panos Deloukas, Stavroula Kanoni, Christina Willenborg, Martin Farrall, Themistocles L Assimes, ..., Colin N A Palmer, Robert Roberts, Hugh Watkins, Heribert Schunkert, Nilesh J Samani
Nature Genetics   ·   02 Dec 2012   ·   doi:10.1038/ng.2480
Identification of the
            <i>BCAR1-CFDP1-TMEM170A</i>
            Locus as a Determinant of Carotid Intima-Media Thickness and Coronary Artery Disease Risk
Identification of the BCAR1-CFDP1-TMEM170A Locus as a Determinant of Carotid Intima-Media Thickness and Coronary Artery Disease Risk
Karl Gertow, Bengt Sennblad, Rona J. Strawbridge, John Öhrvik, Delilah Zabaneh, ..., Damiano Baldassarre, Elena Tremoli, Ulf de Faire, Steve E. Humphries, Anders Hamsten
Circulation: Cardiovascular Genetics   ·   01 Dec 2012   ·   doi:10.1161/CIRCGENETICS.112.963660
Informed Conditioning on Clinical Covariates Increases Power in Case-Control Association Studies
Informed Conditioning on Clinical Covariates Increases Power in Case-Control Association Studies
Noah Zaitlen, Sara Lindström, Bogdan Pasaniuc, Marilyn Cornelis, Giulio Genovese, ..., David Altshuler, Benjamin Voight, Peter Kraft, Nick Patterson, Alkes L. Price
PLoS Genetics   ·   08 Nov 2012   ·   doi:10.1371/journal.pgen.1003032
Human genetics offers an emerging picture of common pathways and mechanisms in autoimmunity
Human genetics offers an emerging picture of common pathways and mechanisms in autoimmunity
Benjamin F Voight, Chris Cotsapas
Current Opinion in Immunology   ·   01 Oct 2012   ·   doi:10.1016/j.coi.2012.07.013
Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes
Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes
Andrew P Morris, Benjamin F Voight, Tanya M Teslovich, Teresa Ferreira, Ayellet V Segrè, ..., Josée Dupuis, James B Meigs, David Altshuler, Michael Boehnke, Mark I McCarthy
Nature Genetics   ·   12 Aug 2012   ·   doi:10.1038/ng.2383
Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways
Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways
Robert A Scott, Vasiliki Lagou, Ryan P Welch, Eleanor Wheeler, May E Montasser, ..., Jose C Florez, Claudia Langenberg, Erik Ingelsson, Inga Prokopenko, Inês Barroso
Nature Genetics   ·   12 Aug 2012   ·   doi:10.1038/ng.2385
The Metabochip, a Custom Genotyping Array for Genetic Studies of Metabolic, Cardiovascular, and Anthropometric Traits
The Metabochip, a Custom Genotyping Array for Genetic Studies of Metabolic, Cardiovascular, and Anthropometric Traits
Benjamin F. Voight, Hyun Min Kang, Jun Ding, Cameron D. Palmer, Carlo Sidore, ..., Joel N. Hirschhorn, David Altshuler, Mark I. McCarthy, Gonçalo R. Abecasis, Michael Boehnke
PLoS Genetics   ·   02 Aug 2012   ·   doi:10.1371/journal.pgen.1002793
Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study
Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study
Benjamin F Voight, Gina M Peloso, Marju Orho-Melander, Ruth Frikke-Schmidt, Maja Barbalic, ..., Daniel J Rader, Leena Peltonen, Stephen M Schwartz, David Altshuler, Sekar Kathiresan
The Lancet   ·   01 Aug 2012   ·   doi:10.1016/S0140-6736(12)60312-2
Impact of Common Variation in Bone-Related Genes on Type 2 Diabetes and Related Traits
Impact of Common Variation in Bone-Related Genes on Type 2 Diabetes and Related Traits
Liana K. Billings, Yi-Hsiang Hsu, Rachel J. Ackerman, Josée Dupuis, Benjamin F. Voight, ..., James S. Pankow, David Karasik, James B. Meigs, Douglas P. Kiel, Jose C. Florez
Diabetes   ·   17 Jul 2012   ·   doi:10.2337/db11-1515
Stratifying Type 2 Diabetes Cases by BMI Identifies Genetic Risk Variants in LAMA1 and Enrichment for Risk Variants in Lean Compared to Obese Cases
Stratifying Type 2 Diabetes Cases by BMI Identifies Genetic Risk Variants in LAMA1 and Enrichment for Risk Variants in Lean Compared to Obese Cases
John R. B. Perry, Benjamin F. Voight, Loïc Yengo, Najaf Amin, Josée Dupuis, ..., Colin N. A. Palmer, Nicholas J. Wareham, Leif Groop, Timothy M. Frayling, Stéphane Cauchi
PLoS Genetics   ·   31 May 2012   ·   doi:10.1371/journal.pgen.1002741
A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance
A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance
Alisa K Manning, Marie-France Hivert, Robert A Scott, Jonna L Grimsby, Nabila Bouatia-Naji, ..., Richard M Watanabe, Jose C Florez, Josée Dupuis, James B Meigs, Claudia Langenberg
Nature Genetics   ·   13 May 2012   ·   doi:10.1038/ng.2274
Analysis of case–control association studies with known risk variants
Analysis of case–control association studies with known risk variants
Noah Zaitlen, Bogdan Paşaniuc, Nick Patterson, Samuela Pollack, Benjamin Voight, ..., Christopher A. Haiman, Barbara E. Stranger, Emmanouil T. Dermitzakis, Peter Kraft, Alkes L. Price
Bioinformatics   ·   03 May 2012   ·   doi:10.1093/bioinformatics/bts259
Meta-analysis identifies six new susceptibility loci for atrial fibrillation
Meta-analysis identifies six new susceptibility loci for atrial fibrillation
Patrick T Ellinor, Kathryn L Lunetta, Christine M Albert, Nicole L Glazer, Marylyn D Ritchie, ..., Daniel I Chasman, Susan R Heckbert, Emelia J Benjamin, Vilmundur Gudnason, Stefan Kääb
Nature Genetics   ·   29 Apr 2012   ·   doi:10.1038/ng.2261
Evaluation of the Metabochip Genotyping Array in African Americans and Implications for Fine Mapping of GWAS-Identified Loci: The PAGE Study
Evaluation of the Metabochip Genotyping Array in African Americans and Implications for Fine Mapping of GWAS-Identified Loci: The PAGE Study
Steven Buyske, Ying Wu, Cara L. Carty, Iona Cheng, Themistocles L. Assimes, ..., Karen L. Mohlke, Christopher A. Haiman, Ulrike Peters, Dana C. Crawford, Kari E. North
PLoS ONE   ·   23 Apr 2012   ·   doi:10.1371/journal.pone.0035651
Patterns and rates of exonic de novo mutations in autism spectrum disorders
Patterns and rates of exonic de novo mutations in autism spectrum disorders
Benjamin M. Neale, Yan Kou, Li Liu, Avi Ma’ayan, Kaitlin E. Samocha, ..., Richard A. Gibbs, Kathryn Roeder, Gerard D. Schellenberg, James S. Sutcliffe, Mark J. Daly
Nature   ·   04 Apr 2012   ·   doi:10.1038/nature11011
Novel Loci for Adiponectin Levels and Their Influence on Type 2 Diabetes and Metabolic Traits: A Multi-Ethnic Meta-Analysis of 45,891 Individuals
Novel Loci for Adiponectin Levels and Their Influence on Type 2 Diabetes and Metabolic Traits: A Multi-Ethnic Meta-Analysis of 45,891 Individuals
Zari Dastani, Marie-France Hivert, Nicholas Timpson, John R. B. Perry, Xin Yuan, ..., Ruth J. F. Loos, Dawn M. Waterworth, James B. Meigs, Josee Dupuis, J. Brent Richards
PLoS Genetics   ·   29 Mar 2012   ·   doi:10.1371/journal.pgen.1002607
Bayesian inference analyses of the polygenic architecture of rheumatoid arthritis
Bayesian inference analyses of the polygenic architecture of rheumatoid arthritis
Eli A Stahl, Daniel Wegmann, Gosia Trynka, Javier Gutierrez-Achury, Ron Do, ..., Katherine A Siminovitch, Jane Worthington, Paul I W de Bakker, Soumya Raychaudhuri, Robert M Plenge
Nature Genetics   ·   25 Mar 2012   ·   doi:10.1038/ng.2232
Large-Scale Gene-Centric Meta-Analysis across 39 Studies Identifies Type 2 Diabetes Loci
Large-Scale Gene-Centric Meta-Analysis across 39 Studies Identifies Type 2 Diabetes Loci
Richa Saxena, Clara C. Elbers, Yiran Guo, Inga Peter, Tom R. Gaunt, ..., Alex Reiner, Donald W. Bowden, Hakon Hakonarson, David S. Siscovick, Brendan J. Keating
The American Journal of Human Genetics   ·   01 Mar 2012   ·   doi:10.1016/j.ajhg.2011.12.022
Single-Cell Analysis Reveals that Noncoding RNAs Contribute to Clonal Heterogeneity by Modulating Transcription Factor Recruitment
Single-Cell Analysis Reveals that Noncoding RNAs Contribute to Clonal Heterogeneity by Modulating Transcription Factor Recruitment
Stacie L. Bumgarner, Gregor Neuert, Benjamin F. Voight, Anna Symbor-Nagrabska, Paula Grisafi, Alexander van Oudenaarden, Gerald R. Fink
Molecular Cell   ·   01 Feb 2012   ·   doi:10.1016/j.molcel.2011.11.029
A Genome-Wide Association Search for Type 2 Diabetes Genes in African Americans
A Genome-Wide Association Search for Type 2 Diabetes Genes in African Americans
Nicholette D. Palmer, Caitrin W. McDonough, Pamela J. Hicks, Bong H. Roh, Maria R. Wing, ..., Charles N. Rotimi, Maggie C. Y. Ng, Carl D. Langefeld, Barry I. Freedman, Donald W. Bowden
PLoS ONE   ·   04 Jan 2012   ·   doi:10.1371/journal.pone.0029202

2011

Genome-Wide Association Study for Coronary Artery Calcification With Follow-Up in Myocardial Infarction
Genome-Wide Association Study for Coronary Artery Calcification With Follow-Up in Myocardial Infarction
Christopher J. O'Donnell, Maryam Kavousi, Albert V. Smith, Sharon L.R. Kardia, Mary F. Feitosa, ..., Patricia A. Peyser, Ingrid B. Borecki, L. Adrienne Cupples, Vilmundur Gudnason, Jacqueline C.M. Witteman
Circulation   ·   01 Dec 2011   ·   doi:10.1161/CIRCULATIONAHA.110.974899
Genome-Wide Association Identifies Nine Common Variants Associated With Fasting Proinsulin Levels and Provides New Insights Into the Pathophysiology of Type 2 Diabetes
Genome-Wide Association Identifies Nine Common Variants Associated With Fasting Proinsulin Levels and Provides New Insights Into the Pathophysiology of Type 2 Diabetes
Rona J. Strawbridge, Josée Dupuis, Inga Prokopenko, Adam Barker, Emma Ahlqvist, ..., Richard M. Watanabe, Erik Ingelsson, Claudia Langenberg, Anders Hamsten, Jose C. Florez
Diabetes   ·   16 Sep 2011   ·   doi:10.2337/db11-0415
Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure
Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure
Louise V Wain, Germaine C Verwoert, Paul F O'Reilly, Gang Shi, Toby Johnson, ..., Mark J Caulfield, Dabeeru C Rao, Martin D Tobin, Paul Elliott, Cornelia M van Duijn
Nature Genetics   ·   11 Sep 2011   ·   doi:10.1038/ng.922
Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk
Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk
[no author info]
Nature   ·   11 Sep 2011   ·   doi:10.1038/nature10405
Pervasive Sharing of Genetic Effects in Autoimmune Disease
Pervasive Sharing of Genetic Effects in Autoimmune Disease
Chris Cotsapas, Benjamin F. Voight, Elizabeth Rossin, Kasper Lage, Benjamin M. Neale, ..., Jane Worthington, John A. Todd, David A. Hafler, Stephen S. Rich, Mark J. Daly
PLoS Genetics   ·   10 Aug 2011   ·   doi:10.1371/journal.pgen.1002254
An Increased Burden of Common and Rare Lipid-Associated Risk Alleles Contributes to the Phenotypic Spectrum of Hypertriglyceridemia
An Increased Burden of Common and Rare Lipid-Associated Risk Alleles Contributes to the Phenotypic Spectrum of Hypertriglyceridemia
Christopher T. Johansen, Jian Wang, Matthew B. Lanktree, Adam D. McIntyre, Matthew R. Ban, ..., Salim Yusuf, Murray W. Huff, Sekar Kathiresan, Henian Cao, Robert A. Hegele
Arteriosclerosis, Thrombosis, and Vascular Biology   ·   01 Aug 2011   ·   doi:10.1161/ATVBAHA.111.226365
A Genome-Wide Association Study Identifies
            <i>LIPA</i>
            as a Susceptibility Gene for Coronary Artery Disease
A Genome-Wide Association Study Identifies LIPA as a Susceptibility Gene for Coronary Artery Disease
Philipp S. Wild, Tanja Zeller, Arne Schillert, Silke Szymczak, Christoph R. Sinning, ..., Laurence Tiret, Veikko Salomaa, Thomas Munzel, Andreas Ziegler, Stefan Blankenberg
Circulation: Cardiovascular Genetics   ·   01 Aug 2011   ·   doi:10.1161/CIRCGENETICS.110.958728
Influence of 9p21.3 Genetic Variants on Clinical and Angiographic Outcomes in Early-Onset Myocardial Infarction
Influence of 9p21.3 Genetic Variants on Clinical and Angiographic Outcomes in Early-Onset Myocardial Infarction
Diego Ardissino, Carlo Berzuini, Piera Angelica Merlini, Pier Mannuccio Mannucci, Aarti Surti, ..., Alberto Piazza, Luisa Foco, Luisa Bernardinelli, David Altshuler, Sekar Kathiresan
Journal of the American College of Cardiology   ·   01 Jul 2011   ·   doi:10.1016/j.jacc.2010.11.075
Genome-Wide Association Analysis Identifies Variants Associated with Nonalcoholic Fatty Liver Disease That Have Distinct Effects on Metabolic Traits
Genome-Wide Association Analysis Identifies Variants Associated with Nonalcoholic Fatty Liver Disease That Have Distinct Effects on Metabolic Traits
Elizabeth K. Speliotes, Laura M. Yerges-Armstrong, Jun Wu, Ruben Hernaez, Lauren J. Kim, ..., Caroline S. Fox, Albert V. Smith, W. H. Linda Kao, Joel N. Hirschhorn, Ingrid B. Borecki
PLoS Genetics   ·   10 Mar 2011   ·   doi:10.1371/journal.pgen.1001324
Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease
Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease
Heribert Schunkert, Inke R König, Sekar Kathiresan, Muredach P Reilly, Themistocles L Assimes, ..., Robert Roberts, Unnur Thorsteinsdottir, Christopher J O'Donnell, Ruth McPherson, Jeanette Erdmann
Nature Genetics   ·   06 Mar 2011   ·   doi:10.1038/ng.784
Testing for an Unusual Distribution of Rare Variants
Testing for an Unusual Distribution of Rare Variants
Benjamin M. Neale, Manuel A. Rivas, Benjamin F. Voight, David Altshuler, Bernie Devlin, Marju Orho-Melander, Sekar Kathiresan, Shaun M. Purcell, Kathryn Roeder, Mark J. Daly
PLoS Genetics   ·   03 Mar 2011   ·   doi:10.1371/journal.pgen.1001322
Power in the phenotypic extremes: a simulation study of power in discovery and replication of rare variants
Power in the phenotypic extremes: a simulation study of power in discovery and replication of rare variants
Lin T. Guey, Jasmina Kravic, Olle Melander, Noël P. Burtt, Jason M. Laramie, ..., Sekar Kathiresan, Leif Groop, Albert B. Seymour, David Altshuler, Benjamin F. Voight
Genetic Epidemiology   ·   09 Feb 2011   ·   doi:10.1002/gepi.20572
Delineating Signals from Association Studies
Delineating Signals from Association Studies
Benjamin F. Voight
Analysis of Complex Disease Association Studies   ·   01 Jan 2011   ·   doi:10.1016/B978-0-12-375142-3.10017-3

2010

Lack of Association Between the Trp719Arg Polymorphism in Kinesin-Like Protein-6 and Coronary Artery Disease in 19 Case-Control Studies
Lack of Association Between the Trp719Arg Polymorphism in Kinesin-Like Protein-6 and Coronary Artery Disease in 19 Case-Control Studies
Themistocles L. Assimes, Hilma Hólm, Sekar Kathiresan, Muredach P. Reilly, Gudmar Thorleifsson, ..., Unnur Thorsteinsdottir, Kari Stefansson, Heribert Schunkert, Nilesh J. Samani, Thomas Quertermous
Journal of the American College of Cardiology   ·   01 Nov 2010   ·   doi:10.1016/j.jacc.2010.06.022
Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution
Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution
Iris M Heid, Anne U Jackson, Joshua C Randall, Thomas W Winkler, Lu Qi, ..., Inês Barroso, Mark I McCarthy, Caroline S Fox, Karen L Mohlke, Cecilia M Lindgren
Nature Genetics   ·   10 Oct 2010   ·   doi:10.1038/ng.685
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index
Elizabeth K Speliotes, Cristen J Willer, Sonja I Berndt, Keri L Monda, Gudmar Thorleifsson, ..., Kari E North, Mark I McCarthy, Joel N Hirschhorn, Erik Ingelsson, Ruth J F Loos
Nature Genetics   ·   10 Oct 2010   ·   doi:10.1038/ng.686
Design of the Coronary ARtery DIsease Genome-Wide Replication And Meta-Analysis (CARDIoGRAM) Study
Design of the Coronary ARtery DIsease Genome-Wide Replication And Meta-Analysis (CARDIoGRAM) Study
Michael Preuss, Inke R. König, John R. Thompson, Jeanette Erdmann, Devin Absher, ..., Andreas Ziegler, Sekar Kathiresan, Muredach P. Reilly, Nilesh J. Samani, Heribert Schunkert
Circulation: Cardiovascular Genetics   ·   01 Oct 2010   ·   doi:10.1161/CIRCGENETICS.109.899443
Hundreds of variants clustered in genomic loci and biological pathways affect human height
Hundreds of variants clustered in genomic loci and biological pathways affect human height
Hana Lango Allen, Karol Estrada, Guillaume Lettre, Sonja I. Berndt, Michael N. Weedon, ..., Cecilia M. Lindgren, Gonçalo R. Abecasis, Kari Stefansson, Timothy M. Frayling, Joel N. Hirschhorn
Nature   ·   29 Sep 2010   ·   doi:10.1038/nature09410
Common Variants at 10 Genomic Loci Influence Hemoglobin A1C Levels via Glycemic and Nonglycemic Pathways
Common Variants at 10 Genomic Loci Influence Hemoglobin A1C Levels via Glycemic and Nonglycemic Pathways
Nicole Soranzo, Serena Sanna, Eleanor Wheeler, Christian Gieger, Dörte Radke, ..., Manjinder S. Sandhu, Matthew M. Heeney, Joseph M. Devaney, Muredach P. Reilly, Sally L. Ricketts
Diabetes   ·   21 Sep 2010   ·   doi:10.2337/db10-0502
Multiethnic Genetic Association Studies Improve Power for Locus Discovery
Multiethnic Genetic Association Studies Improve Power for Locus Discovery
Sara L. Pulit, Benjamin F. Voight, Paul I. W. de Bakker
PLoS ONE   ·   08 Sep 2010   ·   doi:10.1371/journal.pone.0012600
Biological, clinical and population relevance of 95 loci for blood lipids
Biological, clinical and population relevance of 95 loci for blood lipids
Tanya M. Teslovich, Kiran Musunuru, Albert V. Smith, Andrew C. Edmondson, Ioannis M. Stylianou, ..., Cornelia M. van Duijn, Leena Peltonen, Gonçalo R. Abecasis, Michael Boehnke, Sekar Kathiresan
Nature   ·   01 Aug 2010   ·   doi:10.1038/nature09270
Excess of rare variants in genes identified by genome-wide association study of hypertriglyceridemia
Excess of rare variants in genes identified by genome-wide association study of hypertriglyceridemia
Christopher T Johansen, Jian Wang, Matthew B Lanktree, Henian Cao, Adam D McIntyre, ..., Sonia S Anand, Salim Yusuf, Murray W Huff, Sekar Kathiresan, Robert A Hegele
Nature Genetics   ·   25 Jul 2010   ·   doi:10.1038/ng.628
Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis
Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis
Benjamin F Voight, Laura J Scott, Valgerdur Steinthorsdottir, Andrew P Morris, Christian Dina, ..., Cornelia M van Duijn, Kari Stefansson, David Altshuler, Michael Boehnke, Mark I McCarthy
Nature Genetics   ·   27 Jun 2010   ·   doi:10.1038/ng.609
<i>PNPLA3</i>variants specifically confer increased risk for histologic nonalcoholic fatty liver disease but not metabolic disease
PNPLA3variants specifically confer increased risk for histologic nonalcoholic fatty liver disease but not metabolic disease
Elizabeth K. Speliotes, Johannah L. Butler, Cameron D. Palmer, Benjamin F. Voight, Joel N. Hirschhorn
Hepatology   ·   18 May 2010   ·   doi:10.1002/hep.23768
Genome-wide meta-analyses identify multiple loci associated with smoking behavior
Genome-wide meta-analyses identify multiple loci associated with smoking behavior
[no author info]
Nature Genetics   ·   25 Apr 2010   ·   doi:10.1038/ng.571
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk
Josée Dupuis, Claudia Langenberg, Inga Prokopenko, Richa Saxena, Nicole Soranzo, ..., Igor Rudan, Alan F Wright, Michael Stumvoll, Harry Campbell, James F Wilson
Nature Genetics   ·   17 Jan 2010   ·   doi:10.1038/ng.520
Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge
Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge
Richa Saxena, Marie-France Hivert, Claudia Langenberg, Toshiko Tanaka, James S Pankow, ..., Gérard Waeber, Andrew Walley, Dawn M Waterworth, Eleftheria Zeggini, Jing Hua Zhao
Nature Genetics   ·   17 Jan 2010   ·   doi:10.1038/ng.521

2009

A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium
A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium
Nicole Soranzo, Tim D Spector, Massimo Mangino, Brigitte Kühnel, Augusto Rendon, ..., Christa Meisinger, Andreas Greinacher, Panos Deloukas, Willem H Ouwehand, Christian Gieger
Nature Genetics   ·   11 Oct 2009   ·   doi:10.1038/ng.467
Underlying Genetic Models of Inheritance in Established Type 2 Diabetes Associations
Underlying Genetic Models of Inheritance in Established Type 2 Diabetes Associations
Georgia Salanti, Lorraine Southam, David Altshuler, Kristin Ardlie, Inês Barroso, ..., Laura J. Scott, Benjamin F. Voight, Nicholas J. Wareham, Eleftheria Zeggini, John P. A. Ioannidis
American Journal of Epidemiology   ·   14 Jul 2009   ·   doi:10.1093/aje/kwp145
Common body mass index-associated variants confer risk of extreme obesity
Common body mass index-associated variants confer risk of extreme obesity
Chris Cotsapas, Elizabeth K. Speliotes, Ida J. Hatoum, Danielle M. Greenawalt, Radu Dobrin, ..., Benjamin M. Neale, Eric E. Schadt, Joel N. Hirschhorn, Lee M. Kaplan, Mark J. Daly
Human Molecular Genetics   ·   24 Jun 2009   ·   doi:10.1093/hmg/ddp292
Genome-wide association study identifies eight loci associated with blood pressure
Genome-wide association study identifies eight loci associated with blood pressure
Christopher Newton-Cheh, Toby Johnson, Vesela Gateva, Martin D Tobin, Murielle Bochud, ..., Ruth JF Loos, Paul Elliott, Gonçalo R Abecasis, Mark Caulfield, Patricia B Munroe
Nature Genetics   ·   10 May 2009   ·   doi:10.1038/ng.361
Linkage Disequilibrium Mapping of the Replicated Type 2 Diabetes Linkage Signal on Chromosome 1q
Linkage Disequilibrium Mapping of the Replicated Type 2 Diabetes Linkage Signal on Chromosome 1q
Inga Prokopenko, Eleftheria Zeggini, Robert L. Hanson, Braxton D. Mitchell, N. William Rayner, ..., Steven C. Elbein, Panos Deloukas, Clifton Bogardus, Alan R. Shuldiner, Mark I. McCarthy
Diabetes   ·   23 Apr 2009   ·   doi:10.2337/db09-0081
The T-381C SNP in BNP gene may be modestly associated with type 2 diabetes: an updated meta-analysis in 49 279 subjects
The T-381C SNP in BNP gene may be modestly associated with type 2 diabetes: an updated meta-analysis in 49 279 subjects
Hélène Choquet, Christine Cavalcanti-Proença, Cécile Lecoeur, Christian Dina, Stéphane Cauchi, ..., Valgerdur Steinthorsdottir, Kari Stefansson, Beverley Balkau, Philippe Froguel, David Meyre
Human Molecular Genetics   ·   18 Apr 2009   ·   doi:10.1093/hmg/ddp169
New susceptibility locus for coronary artery disease on chromosome 3q22.3
New susceptibility locus for coronary artery disease on chromosome 3q22.3
Jeanette Erdmann, Anika Großhennig, Peter S Braund, Inke R König, Christian Hengstenberg, ..., Panos Deloukas, John R Thompson, Andreas Ziegler, Nilesh J Samani, Heribert Schunkert
Nature Genetics   ·   08 Feb 2009   ·   doi:10.1038/ng.307

2008

Variants in MTNR1B influence fasting glucose levels
Variants in MTNR1B influence fasting glucose levels
Inga Prokopenko, Claudia Langenberg, Jose C Florez, Richa Saxena, Nicole Soranzo, ..., Kari Stefansson, Mark I McCarthy, Nicholas J Wareham, James B Meigs, Gonçalo R Abecasis
Nature Genetics   ·   07 Dec 2008   ·   doi:10.1038/ng.290
Common variants at 30 loci contribute to polygenic dyslipidemia
Common variants at 30 loci contribute to polygenic dyslipidemia
Sekar Kathiresan, Cristen J Willer, Gina M Peloso, Serkalem Demissie, Kiran Musunuru, ..., Jose M Ordovas, Michael Boehnke, Gonçalo R Abecasis, Karen L Mohlke, L Adrienne Cupples
Nature Genetics   ·   07 Dec 2008   ·   doi:10.1038/ng.291
Common Missense Variant in the Glucokinase Regulatory Protein Gene Is Associated With Increased Plasma Triglyceride and C-Reactive Protein but Lower Fasting Glucose Concentrations
Common Missense Variant in the Glucokinase Regulatory Protein Gene Is Associated With Increased Plasma Triglyceride and C-Reactive Protein but Lower Fasting Glucose Concentrations
Marju Orho-Melander, Olle Melander, Candace Guiducci, Pablo Perez-Martinez, Dolores Corella, ..., Peter Nilsson, Leif Groop, David Altshuler, Jose M. Ordovas, Sekar Kathiresan
Diabetes   ·   01 Nov 2008   ·   doi:10.2337/db08-0516
Practical aspects of imputation-driven meta-analysis of genome-wide association studies
Practical aspects of imputation-driven meta-analysis of genome-wide association studies
P. I.W. de Bakker, M. A.R. Ferreira, X. Jia, B. M. Neale, S. Raychaudhuri, B. F. Voight
Human Molecular Genetics   ·   15 Oct 2008   ·   doi:10.1093/hmg/ddn288
Common variants near MC4R are associated with fat mass, weight and risk of obesity
Common variants near MC4R are associated with fat mass, weight and risk of obesity
Ruth J F Loos, Cecilia M Lindgren, Shengxu Li, Eleanor Wheeler, Jing Hua Zhao, ..., Vincent Mooser, Panos Deloukas, Mark I McCarthy, Nicholas J Wareham, Inês Barroso
Nature Genetics   ·   04 May 2008   ·   doi:10.1038/ng.140
Identification of ten loci associated with height highlights new biological pathways in human growth
Identification of ten loci associated with height highlights new biological pathways in human growth
Guillaume Lettre, Anne U Jackson, Christian Gieger, Fredrick R Schumacher, Sonja I Berndt, ..., Richard B Hayes, Gonçalo R Abecasis, H-Erich Wichmann, Karen L Mohlke, Joel N Hirschhorn
Nature Genetics   ·   06 Apr 2008   ·   doi:10.1038/ng.125
Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes
Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes
Eleftheria Zeggini, Laura J Scott, Richa Saxena, Benjamin F Voight, Jonathan L Marchini, ..., Francis S Collins, Leif Groop, Mark I McCarthy, Michael Boehnke, David Altshuler
Nature Genetics   ·   30 Mar 2008   ·   doi:10.1038/ng.120
Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans
Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans
Sekar Kathiresan, Olle Melander, Candace Guiducci, Aarti Surti, Noël P Burtt, ..., Veikko Salomaa, Leena Peltonen, Leif Groop, David M Altshuler, Marju Orho-Melander
Nature Genetics   ·   13 Jan 2008   ·   doi:10.1038/ng.75

2007

A common variant of HMGA2 is associated with adult and childhood height in the general population
A common variant of HMGA2 is associated with adult and childhood height in the general population
Michael N Weedon, Guillaume Lettre, Rachel M Freathy, Cecilia M Lindgren, Benjamin F Voight, ..., Leif C Groop, Andrew T Hattersley, Mark I McCarthy, Joel N Hirschhorn, Timothy M Frayling
Nature Genetics   ·   02 Sep 2007   ·   doi:10.1038/ng2121
Genome-Wide Association Analysis Identifies Loci for Type 2 Diabetes and Triglyceride Levels
Genome-Wide Association Analysis Identifies Loci for Type 2 Diabetes and Triglyceride Levels
Richa Saxena, Benjamin F. Voight, Valeriya Lyssenko, Noël P. Burtt, Paul I. W. de Bakker, ..., Qicheng Ma, Hemang Parikh, Delwood Richardson, Darrell Ricke, Shaun Purcell
Science   ·   01 Jun 2007   ·   doi:10.1126/science.1142358

2006

Convergent adaptation of human lactase persistence in Africa and Europe
Convergent adaptation of human lactase persistence in Africa and Europe
Sarah A Tishkoff, Floyd A Reed, Alessia Ranciaro, Benjamin F Voight, Courtney C Babbitt, ..., Jilur Ghori, Suzannah Bumpstead, Jonathan K Pritchard, Gregory A Wray, Panos Deloukas
Nature Genetics   ·   10 Dec 2006   ·   doi:10.1038/ng1946
Coverage and Characteristics of the Affymetrix GeneChip Human Mapping 100K SNP Set
Coverage and Characteristics of the Affymetrix GeneChip Human Mapping 100K SNP Set
Dan L Nicolae, Xiaoquan Wen, Benjamin F Voight, Nancy J Cox
PLoS Genetics   ·   05 May 2006   ·   doi:10.1371/journal.pgen.0020067
A Map of Recent Positive Selection in the Human Genome
A Map of Recent Positive Selection in the Human Genome
Benjamin F Voight, Sridhar Kudaravalli, Xiaoquan Wen, Jonathan K Pritchard
PLoS Biology   ·   07 Mar 2006   ·   doi:10.1371/journal.pbio.0040072

2005

Interrogating multiple aspects of variation in a full resequencing data set to infer human population size changes
Interrogating multiple aspects of variation in a full resequencing data set to infer human population size changes
Benjamin F. Voight, Alison M. Adams, Linda A. Frisse, Yudong Qian, Richard R. Hudson, Anna Di Rienzo
Proceedings of the National Academy of Sciences   ·   13 Dec 2005   ·   doi:10.1073/pnas.0507325102
Confounding from Cryptic Relatedness in Case-Control Association Studies
Confounding from Cryptic Relatedness in Case-Control Association Studies
Benjamin F Voight, Jonathan K Pritchard
PLoS Genetics   ·   02 Sep 2005   ·   doi:10.1371/journal.pgen.0010032