Publications

We have created extensive scholarship around method development and analysis of genetic data in humans, the central focus of my lab.

My roots began in population genetics, aiming to understand how the genome reveals details of our evolutionary history. Today, we are very are active in the development of methods in population genomics, which include characterization of mutation rates and studies of natural selection in human populations.

We are actively interested in the genetic dissection of complex traits. The statistical pipelines that we have developed and applied over my career have resulting in discovery of thousands of loci for complex traits, focused on type 2 diabetes, cardiovascular disease, and liver disease. This also include mapping of genetic variation associated with molecular phenotypes (eQTLs, sQTLs, caQTLs, etc.) using bulk tissue, cell model, and even single-cell resources in tissues relevant to these endpoints (e.g., pancreas).

We also have an active interest in the application of Mendelian randomization (MR) to evaluate causal hypotheses between biomarkers and cardiometabolic endpoints, including most famously rejecting a protective role for HDL Cholesterol in heart disease.

I need to prettify the publication listing below (Work in progress)!

But feel free to follow the Pubmed and Google Scholar links below to see a full list of my publications.

All

Selected Works:

Discipline/Approach Areas:

Phenotypic Areas:

Consortia Work:

Approaches/Software:

2025

G6PC2 controls glucagon secretion by defining the set point for glucose in pancreatic α cells

Varun Bahl, Reut Rifkind, Eric Waite, Zenab Hamdan, Catherine Lee May, ..., Mark Tigue, Nicholas Manuto, Benjamin Glaser, Dana Avrahami, Klaus H. Kaestner

Science Translational Medicine   ·   01 Jan 2025   ·   doi:10.1126/scitranslmed.adi6148

2024

Characterization of non-coding variants associated with transcription factor binding through ATAC-seq-defined footprint QTLs in liver

Max F. Dudek, Brandon M. Wenz, Christopher D. Brown, Benjamin F. Voight, Laura Almasy, Struan F.A. Grant

Cold Spring Harbor Laboratory   ·   25 Sep 2024   ·   doi:10.1101/2024.09.24.614730

Genotype inference from aggregated chromatin accessibility data reveals genetic regulatory mechanisms

Brandon M. Wenz, Yuan He, Nae-Chyun Chen, Joseph K. Pickrell, Jeremiah H. Li, ..., Taibo Li, Rebecca Keener, Benjamin F. Voight, Christopher D. Brown, Alexis Battle

Cold Spring Harbor Laboratory   ·   05 Sep 2024   ·   doi:10.1101/2024.09.04.610850

Mendelian randomization analyses clarify the effects of height on cardiovascular diseases

Daniel Hui, Eric Sanford, Kimberly Lorenz, Scott M. Damrauer, Themistocles L. Assimes, Christopher S. Thom, Benjamin F. Voight

PLOS ONE   ·   03 Jul 2024   ·   doi:10.1371/journal.pone.0298786

Clinical and genetic risk factors for progressive fibrosis in metabolic dysfunction–associated steatotic liver disease

David E. Kaplan, Craig C. Teerlink, Tae-Hwi Schwantes-An, Trina M. Norden-Krichmar, Scott L. DuVall, ..., Philip S. Tsao, Benjamin F. Voight, Julie A. Lynch, Marijana Vujković, Kyong-Mi Chang

Hepatology Communications   ·   01 Jul 2024   ·   doi:10.1097/HC9.0000000000000487

Dietary preference and susceptibility to type 2 diabetes mellitus: a wide-angle Mendelian randomization study

Mia D. Lee, Benjamin F. Voight

Cold Spring Harbor Laboratory   ·   06 May 2024   ·   doi:10.1101/2024.05.05.24306877

Evaluation of Plasma Biomarkers for Causal Association With Peripheral Artery Disease

Pranav Sharma, Derek Klarin, Benjamin F. Voight, Philip S. Tsao, Michael G. Levin, Scott M. Damrauer

Arteriosclerosis, Thrombosis, and Vascular Biology   ·   01 May 2024   ·   doi:10.1161/ATVBAHA.124.320674

Major Depressive Disorder Impacts Peripheral Artery Disease Risk Through Intermediary Risk Factors

Gabrielle Shakt, Noah L. Tsao, Michael G. Levin, Venexia Walker, Rachel L. Kember, Derek Klarin, Phil Tsao, Benjamin F. Voight, Salvatore T. Scali, Scott M. Damrauer

Journal of the American Heart Association   ·   20 Feb 2024   ·   doi:10.1161/JAHA.123.030233

PubMed

Complex Traits Mendelian Randomization CAD/CVD Pleiotropy Collaborative

Genetic drivers of heterogeneity in type 2 diabetes pathophysiology

Ken Suzuki, Konstantinos Hatzikotoulas, Lorraine Southam, Henry J. Taylor, Xianyong Yin, ..., Jerome I. Rotter, Marijana Vujkovic, Benjamin F. Voight, Andrew P. Morris, Eleftheria Zeggini

Nature   ·   19 Feb 2024   ·   doi:10.1038/s41586-024-07019-6

PubMed

Selected Work Complex Traits T2D CAD/CVD Pleiotropy Consortia T2D-GGI MVP

Trans-ancestral genome-wide association study of longitudinal pubertal height growth and shared heritability with adult health outcomes

Jonathan P. Bradfield, Rachel L. Kember, Anna Ulrich, Zhanna Balkhiyarova, Akram Alyass, ..., Inga Prokopenko, Benjamin F. Voight, Babette S. Zemel, Struan F. A. Grant, Diana L. Cousminer

Genome Biology   ·   16 Jan 2024   ·   doi:10.1186/s13059-023-03136-z

PubMed

Selected Work Complex Traits Consortia Collaborative

2023

Projecting genetic associations through gene expression patterns highlights disease etiology and drug mechanisms

Milton Pividori, Sumei Lu, Binglan Li, Chun Su, Matthew E. Johnson, ..., Benjamin F. Voight, Carsten Skarke, Marylyn D. Ritchie, Struan F. A. Grant, Casey S. Greene

Nature Communications   ·   09 Sep 2023   ·   doi:10.1038/s41467-023-41057-4

PubMed

Complex Traits Pleiotropy AI/ML Methods Development Software

Deciphering the genetic architecture of atrial fibrillation offers insights into disease prediction, pathophysiology and downstream sequelae

Shuai Yuan, Yuying Li, Lijuan Wang, Fengzhe Xu, Jie Chen, ..., Agneta Åkesson, Karl Michaëlsson, Xue Li, Xia Shen, Susanna C. Larsson

Cold Spring Harbor Laboratory   ·   25 Jul 2023   ·   doi:10.1101/2023.07.20.23292938

PubMed

Preprint Complex Traits CAD/CVD Collaborative

Regularized sequence-context mutational trees capture variation in mutation rates across the human genome

Christopher J. Adams, Mitchell Conery, Benjamin J. Auerbach, Shane T. Jensen, Iain Mathieson, Benjamin F. Voight

PLOS Genetics   ·   07 Jul 2023   ·   doi:10.1371/journal.pgen.1010807

PubMed

GitHub

Selected Work Pop Gen Mutation Rate Statistics Methods Development Software

Evaluating the Contribution of Cell Type–Specific Alternative Splicing to Variation in Lipid Levels

Katerina A.B. Gawronski, William P. Bone, YoSon Park, Evanthia E. Pashos, Brandon M. Wenz, ..., Wenli Yang, Daniel J. Rader, Kiran Musunuru, Benjamin F. Voight, Christopher D. Brown

Circulation: Genomic and Precision Medicine   ·   01 Jun 2023   ·   doi:10.1161/CIRCGEN.120.003249

PubMed

Selected Work Complex Traits QTL Mapping

Evaluating the Contribution of Cell Type–Specific Alternative Splicing to Variation in Lipid Levels

Katerina A.B. Gawronski, William P. Bone, YoSon Park, Evanthia E. Pashos, Brandon M. Wenz, ..., Wenli Yang, Daniel J. Rader, Kiran Musunuru, Benjamin F. Voight, Christopher D. Brown

Circulation: Genomic and Precision Medicine   ·   01 Jun 2023   ·   doi:10.1161/circgen.120.003249

G6PC2 controls glucagon secretion by defining the setpoint for glucose in pancreatic α-cells

Varun Bahl, Eric Waite, Reut Rifkind, Zenab Hamdan, Catherine Lee May, ..., Mark Tigue, Nicholas Manuto, Benjamin Glaser, Dana Avrahami, Klaus H. Kaestner

Cold Spring Harbor Laboratory   ·   24 May 2023   ·   doi:10.1101/2023.05.23.541901

Preprint T2D T1D Consortia Collaborative

Genetically proxied glucose-lowering drug target perturbation and risk of cancer: a Mendelian randomisation analysis

James Yarmolinsky, Emmanouil Bouras, Andrei Constantinescu, Kimberley Burrows, Caroline J. Bull, ..., Peter Kraft, William J. Blot, Elio Riboli, Dipender Gill, Kostas K. Tsilidis

Diabetologia   ·   12 May 2023   ·   doi:10.1007/s00125-023-05925-4

PubMed

Complex Traits Mendelian Randomization Pleiotropy Collaborative

Evaluation of the Performance of the RECODe Equation with the Addition of Polygenic Risk Scores for Adverse Cardiovascular Outcomes in Individuals with Type II Diabetes

Noah L. Tsao, Renae Judy, Michael G. Levin, Gabrielle Shakt, Benjamin F. Voight, Jinbo Chen, Scott M. Damrauer

Cold Spring Harbor Laboratory   ·   05 May 2023   ·   doi:10.1101/2023.05.03.23289457

PubMed

Preprint Complex Traits T2D CAD/CVD Pleiotropy Collaborative

Evaluation of plasma biomarkers for causal association with peripheral artery disease

Pranav Sharma, Michael G. Levin, Derek Klarin, Benjamin F. Voight, Philip S. Tsao, Scott M. Damrauer

Cold Spring Harbor Laboratory   ·   05 May 2023   ·   doi:10.1101/2023.05.05.23289560

Preprint Complex Traits Mendelian Randomization CAD/CVD Pleiotropy Collaborative

Mendelian Randomization Analysis Reveals a Complex Genetic Interplay among Atopic Dermatitis, Asthma, and Gastroesophageal Reflux Disease

Kwangmi Ahn, Raymond B. Penn, Satish Rattan, Reynold A. Panettieri, Benjamin F. Voight, Steven S. An

American Journal of Respiratory and Critical Care Medicine   ·   15 Jan 2023   ·   doi:10.1164/rccm.202205-0951OC

PubMed

Complex Traits Mendelian Randomization Collaborative

Mendelian Randomization Analysis Reveals a Complex Genetic Interplay among Atopic Dermatitis, Asthma, and Gastroesophageal Reflux Disease

Kwangmi Ahn, Raymond B. Penn, Satish Rattan, Reynold A. Panettieri, Benjamin F. Voight, Steven S. An

American Journal of Respiratory and Critical Care Medicine   ·   15 Jan 2023   ·   doi:10.1164/rccm.202205-0951oc

2022

Genomics and phenomics of body mass index reveals a complex disease network

Jie Huang, Jennifer E. Huffman, Yunfeng Huang, Ítalo Do Valle, Themistocles L. Assimes, ..., Kelly Cho, Kyong-Mi Chang, Peter W. F. Wilson, Yan V. Sun, Christopher J. O’Donnell

Nature Communications   ·   29 Dec 2022   ·   doi:10.1038/s41467-022-35553-2

PubMed

Complex Traits Mendelian Randomization Pleiotropy Consortia Collaborative MVP

Genome-wide association and multi-trait analyses characterize the common genetic architecture of heart failure

Michael G. Levin, Noah L. Tsao, Pankhuri Singhal, Chang Liu, Ha My T. Vy, ..., Christopher M. Haggerty, Jacob Joseph, Yan V. Sun, Benjamin F. Voight, Scott M. Damrauer

Nature Communications   ·   14 Nov 2022   ·   doi:10.1038/s41467-022-34216-6

PubMed

Selected Work Complex Traits Mendelian Randomization CAD/CVD Pleiotropy

Regularized sequence-context mutational trees capture variation in mutation rates across the human genome

Christopher J. Adams, Mitchell Conery, Benjamin J. Auerbach, Shane T. Jensen, Iain Mathieson, Benjamin F. Voight

Cold Spring Harbor Laboratory   ·   17 Oct 2022   ·   doi:10.1101/2022.10.14.512160

GitHub

Preprint Pop Gen Mutation Rate Statistics Methods Development Software

Estimating the effect size of a hidden causal factor between SNPs and a continuous trait: a mediation model approach

Zhuoran Ding, Marylyn D. Ritchie, Benjamin F. Voight, Wei-Ting Hwang

BMC Bioinformatics   ·   13 Oct 2022   ·   doi:10.1186/s12859-022-04977-4

PubMed

PDF

GitHub

Selected Work Complex Traits Statistics Methods Development Software

Identifying rare variants inconsistent with identity‐by‐descent in population‐scale whole‐genome sequencing data

Kelsey E. Johnson, Christopher J. Adams, Benjamin F. Voight

Methods in Ecology and Evolution   ·   11 Oct 2022   ·   doi:10.1111/2041-210X.13991

PDF

GitHub

Selected Work Pop Gen Mutation Rate Statistics Methods Development Software

Polygenic Risk Scores in Alzheimer’s Disease Genetics: Methodology, Applications, Inclusion, and Diversity

Kaylyn Clark, Yuk Yee Leung, Wan-Ping Lee, Benjamin Voight, Li-San Wang

Journal of Alzheimer's Disease   ·   30 Aug 2022   ·   doi:10.3233/JAD-220025

PubMed

Complex Traits Opinion/Review/Book Chapter

Large-scale genome-wide association study of coronary artery disease in genetically diverse populations

Catherine Tcheandjieu, Xiang Zhu, Austin T. Hilliard, Shoa L. Clarke, Valerio Napolioni, ..., Hua Tang, Yan V. Sun, Philip S. Tsao, Christopher J. O’Donnell, Themistocles L. Assimes

Nature Medicine   ·   01 Aug 2022   ·   doi:10.1038/s41591-022-01891-3

PubMed

Complex Traits CAD/CVD Consortia Collaborative MVP

ColocQuiaL: a QTL-GWAS colocalization pipeline

Brian Y Chen, William P Bone, Kim Lorenz, Michael Levin, Marylyn D Ritchie, Benjamin F Voight

Bioinformatics   ·   27 Jul 2022   ·   doi:10.1093/bioinformatics/btac512

PubMed

GitHub

Selected Work Complex Traits Automation Methods Development Software

Estimating the effect size of a hidden causal factor between SNPs and a continuous trait: a mediation model approach

Zhuoran Ding, Marylyn D. Ritchie, Benjamin F. Voight, Wei-Ting Hwang

Cold Spring Harbor Laboratory   ·   29 Jun 2022   ·   doi:10.1101/2022.06.28.497617

GitHub

Preprint Complex Traits Statistics Methods Development Software

Epigenomic and transcriptomic analyses define core cell types, genes and targetable mechanisms for kidney disease

Hongbo Liu, Tomohito Doke, Dong Guo, Xin Sheng, Ziyuan Ma, ..., Hongzhe Li, Christopher D. Brown, Marylyn D. Ritchie, Yan Shu, Katalin Susztak

Nature Genetics   ·   16 Jun 2022   ·   doi:10.1038/s41588-022-01097-w

PubMed

Complex Traits QTL Mapping Collaborative

TSABL: Trait Specific Annotation Based Locus predictor

Kim Lorenz, Christopher S. Thom, Sanjana Adurty, Benjamin F. Voight

BMC Genomics   ·   15 Jun 2022   ·   doi:10.1186/s12864-022-08654-x

PubMed

Selected Work Complex Traits Pleiotropy AI/ML Methods Development Software

Characterization of the genome and silk-gland transcriptomes of Darwin’s bark spider (Caerostris darwini)

Paul L. Babb, Matjaž Gregorič, Nicholas F. Lahens, David N. Nicholson, Cheryl Y. Hayashi, Linden Higgins, Matjaž Kuntner, Ingi Agnarsson, Benjamin F. Voight

PLOS ONE   ·   06 Jun 2022   ·   doi:10.1371/journal.pone.0268660

PubMed

PDF

Selected Work Pop Gen Spiders

A multi-population phenome-wide association study of genetically-predicted height in the Million Veteran Program

Sridharan Raghavan, Jie Huang, Catherine Tcheandjieu, Jennifer E. Huffman, Elizabeth Litkowski, ..., Kyong-Mi Chang, Kelly Cho, Christopher J. O’Donnell, Yan V. Sun, Themistocles L. Assimes

PLOS Genetics   ·   02 Jun 2022   ·   doi:10.1371/journal.pgen.1010193

PubMed

Complex Traits Mendelian Randomization Pleiotropy Collaborative MVP

A multiancestry genome-wide association study of unexplained chronic ALT elevation as a proxy for nonalcoholic fatty liver disease with histological and radiological validation

Marijana Vujkovic, Shweta Ramdas, Kim M. Lorenz, Xiuqing Guo, Rebecca Darlay, ..., Jerome I. Rotter, Julie A. Lynch, Daniel J. Rader, Benjamin F. Voight, Kyong-Mi Chang

Nature Genetics   ·   01 Jun 2022   ·   doi:10.1038/s41588-022-01078-z

PubMed

Selected Work Complex Traits MASLD Consortia MVP

Multi‐phenotype analyses of hemostatic traits with cardiovascular events reveal novel genetic associations

Gerard Temprano‐Sagrera, Colleen M. Sitlani, William P. Bone, Miguel Martin‐Bornez, Benjamin F. Voight, ..., Hugh S Markus, Joanna MM Howson, Yoichiro Kamatani, Stephanie Debette, Martin Dichgans

Journal of Thrombosis and Haemostasis   ·   01 Jun 2022   ·   doi:10.1111/jth.15698

PubMed

PDF

Complex Traits CAD/CVD Pleiotropy Collaborative

A Phenome-Wide Association Study of genes associated with COVID-19 severity reveals shared genetics with complex diseases in the Million Veteran Program

Anurag Verma, Noah L. Tsao, Lauren O. Thomann, Yuk-Lam Ho, Sudha K. Iyengar, ..., Philip S. Tsao, J. Michael Gaziano, Christopher O’Donnell, Scott M. Damrauer, Katherine P. Liao

PLOS Genetics   ·   28 Apr 2022   ·   doi:10.1371/journal.pgen.1010113

PubMed

PDF

Complex Traits Collaborative MVP

Body mass index and adipose distribution have opposing genetic impacts on human blood traits

Christopher S Thom, Madison B Wilken, Stella T Chou, Benjamin F Voight

eLife   ·   15 Feb 2022   ·   doi:10.7554/eLife.75317

PubMed

Selected Work Complex Traits Mendelian Randomization Pleiotropy

Body mass index and adipose distribution have opposing genetic impacts on human blood traits

Christopher S Thom, Madison B Wilken, Stella T Chou, Benjamin F Voight

eLife   ·   15 Feb 2022   ·   doi:10.7554/elife.75317

Separating the direct effects of traits on atherosclerotic cardiovascular disease from those mediated by type 2 diabetes

Venexia M. Walker, Marijana Vujkovic, Alice R. Carter, Neil M. Davies, Miriam S. Udler, Michael G. Levin, George Davey Smith, Benjamin F. Voight, Tom R. Gaunt, Scott M. Damrauer

Diabetologia   ·   07 Feb 2022   ·   doi:10.1007/s00125-022-05653-1

PubMed

PDF

Complex Traits Mendelian Randomization T2D CAD/CVD Pleiotropy Collaborative

Multi-Trait Genome-Wide Association Study of Atherosclerosis Detects Novel Pleiotropic Loci

Tiffany R. Bellomo, William P. Bone, Brian Y. Chen, Katerina A. B. Gawronski, David Zhang, ..., Philip S. Tsao, Daniel J. Rader, Marylyn D. Ritchie, Scott M. Damrauer, Benjamin F. Voight

Frontiers in Genetics   ·   02 Feb 2022   ·   doi:10.3389/fgene.2021.787545

PubMed

Selected Work Complex Traits CAD/CVD Pleiotropy

2021

Mendelian randomization analyses clarify the effects of height on cardiovascular diseases

Daniel Hui, Eric Sanford, Kimberly Lorenz, Scott M. Damrauer, Themistocles L. Assimes, Christopher S. Thom, Benjamin F. Voight

Cold Spring Harbor Laboratory   ·   17 Dec 2021   ·   doi:10.1101/2021.12.16.21267869

Preprint Complex Traits Mendelian Randomization CAD/CVD Pleiotropy

Cis-regulatory architecture of human ESC-derived hypothalamic neuron differentiation aids in variant-to-gene mapping of relevant complex traits

Matthew C. Pahl, Claudia A. Doege, Kenyaita M. Hodge, Sheridan H. Littleton, Michelle E. Leonard, ..., Andrew D. Wells, Benjamin F. Voight, Rudolph L. Leibel, Diana L. Cousminer, Struan F. A. Grant

Nature Communications   ·   19 Nov 2021   ·   doi:10.1038/s41467-021-27001-4

PubMed

Complex Traits Collaborative

ColocQuiaL: A QTL-GWAS colocalization pipeline

Brian Y. Chen, William P. Bone, Kimberly Lorenz, Michael Levin, Marylyn D. Ritchie, Benjamin F. Voight

Cold Spring Harbor Laboratory   ·   09 Nov 2021   ·   doi:10.1101/2021.11.05.21265991

GitHub

Preprint Complex Traits Automation Methods Development Software

Obesity and adiposity have opposing genetic impacts on human blood traits

Christopher S Thom, Madison B Wilken, Stella T Chou, Benjamin F Voight

Cold Spring Harbor Laboratory   ·   07 Nov 2021   ·   doi:10.1101/2021.11.05.467482

Preprint Complex Traits Mendelian Randomization Pleiotropy

A Missense Variant in the IL-6 Receptor and Protection From Peripheral Artery Disease

Michael G. Levin, Derek Klarin, Marios K. Georgakis, Julie Lynch, Katherine P. Liao, ..., Christopher J. O’Donnell, Kyong-Mi Chang, Themistocles L. Assimes, Philip S. Tsao, Scott M. Damrauer

Circulation Research   ·   29 Oct 2021   ·   doi:10.1161/CIRCRESAHA.121.319589

PubMed

Complex Traits Mendelian Randomization CAD/CVD Collaborative

TSABL: Trait Specific Annotation Based Locus Predictor

Kimberly Lorenz, Christopher S. Thom, Sanjana Adurty, Benjamin F. Voight

Cold Spring Harbor Laboratory   ·   29 Sep 2021   ·   doi:10.1101/2021.09.27.21264198

Preprint Complex Traits Pleiotropy AI/ML Methods Development Software

Evaluation of height as a disease risk factor through a phenome-wide association study of genetically-predicted height

Sridharan Raghavan, Jie Huang, Catherine Tcheandjieu, Jennifer E. Huffman, Elizabeth Litkowski, ..., Kyong-Mi Chang, Kelly Cho, Christopher J. O’Donnell, Yan V. Sun, Themistocles L. Assimes

Cold Spring Harbor Laboratory   ·   30 Aug 2021   ·   doi:10.1101/2021.08.29.21262793

Preprint Complex Traits Mendelian Randomization Pleiotropy

A single genetic locus controls both expression of DPEP1/CHMP1A and kidney disease development via ferroptosis

Yuting Guan, Xiujie Liang, Ziyuan Ma, Hailong Hu, Hongbo Liu, Zhen Miao, Andreas Linkermann, Jacklyn N. Hellwege, Benjamin F. Voight, Katalin Susztak

Nature Communications   ·   23 Aug 2021   ·   doi:10.1038/s41467-021-25377-x

PubMed

Complex Traits Collaborative

Mapping the genetic architecture of human traits to cell types in the kidney identifies mechanisms of disease and potential treatments

Xin Sheng, Yuting Guan, Ziyuan Ma, Junnan Wu, Hongbo Liu, ..., Mingyao Li, Benjamin F. Voight, Thomas M. Coffman, Christopher D. Brown, Katalin Susztak

Nature Genetics   ·   12 Aug 2021   ·   doi:10.1038/s41588-021-00909-9

PubMed

Complex Traits QTL Mapping Collaborative

Separating the direct effects of risk factors for atherosclerotic cardiovascular disease from those mediated by type 2 diabetes

Venexia M Walker, Marijana Vujkovic, Alice R Carter, Neil M Davies, Miriam S Udler, Michael G Levin, George Davey Smith, Benjamin F Voight, Tom R Gaunt, Scott M Damrauer

Cold Spring Harbor Laboratory   ·   07 Aug 2021   ·   doi:10.1101/2021.08.05.21261658

Preprint Mendelian Randomization T2D CAD/CVD Pleiotropy

Multi-ancestry Multivariate Genome-Wide Analysis Highlights the Role of Common Genetic Variation in Cardiac Structure, Function, and Heart Failure-related Traits

Michael G. Levin, Noah L. Tsao, Tiffany R. Bellomo, William P. Bone, Krishna G. Aragam, ..., Sharlene M. Day, Patrick T. Ellinor, Kenneth B. Margulies, Benjamin F. Voight, Scott M. Damrauer

Cold Spring Harbor Laboratory   ·   05 Aug 2021   ·   doi:10.1101/2021.08.03.21261508

Preprint Complex Traits CAD/CVD Pleiotropy

Prioritizing the Role of Major Lipoproteins and Subfractions as Risk Factors for Peripheral Artery Disease

Michael G. Levin, Verena Zuber, Venexia M. Walker, Derek Klarin, Julie Lynch, ..., Philip S. Tsao, Benjamin F. Voight, Dipender Gill, Stephen Burgess, Scott M. Damrauer

Circulation   ·   03 Aug 2021   ·   doi:10.1161/CIRCULATIONAHA.121.053797

PubMed

Complex Traits Mendelian Randomization CAD/CVD Pleiotropy

Projecting genetic associations through gene expression patterns highlights disease etiology and drug mechanisms

Milton Pividori, Sumei Lu, Binglan Li, Chun Su, Matthew E. Johnson, ..., Benjamin F. Voight, Carsten Skarke, Marylyn D. Ritchie, Struan F.A. Grant, Casey S. Greene

Cold Spring Harbor Laboratory   ·   06 Jul 2021   ·   doi:10.1101/2021.07.05.450786

Preprint

Genetic Evidence for Repurposing of GLP1R (Glucagon‐Like Peptide‐1 Receptor) Agonists to Prevent Heart Failure

Iyas Daghlas, Ville Karhunen, Devleena Ray, Verena Zuber, Stephen Burgess, ..., Emma H. Baker, Scott M. Damrauer, Joanna M. M. Howson, Marijana Vujkovic, Dipender Gill

Journal of the American Heart Association   ·   06 Jul 2021   ·   doi:10.1161/JAHA.120.020331

PubMed

Complex Traits Mendelian Randomization CAD/CVD Collaborative

A unified framework identifies new links between plasma lipids and diseases from electronic medical records across large-scale cohorts

Yogasudha Veturi, Anastasia Lucas, Yuki Bradford, Daniel Hui, Scott Dudek, ..., Thomas J. Hoffmann, Neil Risch, Benjamin F. Voight, Daniel J. Rader, Marylyn D. Ritchie

Nature Genetics   ·   17 Jun 2021   ·   doi:10.1038/s41588-021-00879-y

PubMed

Complex Traits Mendelian Randomization Pleiotropy Collaborative

Association Between Genetic Variation in Blood Pressure and Increased Lifetime Risk of Peripheral Artery Disease

Michael G. Levin, Derek Klarin, Venexia M. Walker, Dipender Gill, Julie Lynch, ..., Neil M. Davies, Philip S. Tsao, Kyong-Mi Chang, Benjamin F. Voight, Scott M. Damrauer

Arteriosclerosis, Thrombosis, and Vascular Biology   ·   01 Jun 2021   ·   doi:10.1161/ATVBAHA.120.315482

PubMed

Selected Work Complex Traits Mendelian Randomization CAD/CVD Pleiotropy

Multi-trait GWAS of atherosclerosis detects novel pleiotropic loci

Tiffany R. Bellomo, William P. Bone, Brian Y. Chen, Katerina A. B. Gawronski, David Zhang, ..., Phil S. Tsao, Daniel J. Rader, Marylyn D. Ritchie, Benjamin F. Voight, Scott M. Damrauer

Cold Spring Harbor Laboratory   ·   23 May 2021   ·   doi:10.1101/2021.05.21.21257493

Preprint Complex Traits CAD/CVD Pleiotropy

A Phenome-Wide Association Study of genes associated with COVID-19 severity reveals shared genetics with complex diseases in the Million Veteran Program

Anurag Verma, Noah Tsao, Lauren Thomann, Yuk-Lam Ho, Sudha Iyengar, ..., Philip S. Tsao, J. Michael Gaziano, Christopher O’Donnell, Scott Damrauer, Katherine Liao

Cold Spring Harbor Laboratory   ·   23 May 2021   ·   doi:10.1101/2021.05.18.21257396

Preprint Complex Traits Consortia Collaborative MVP

Genetic analysis in European ancestry individuals identifies 517 loci associated with liver enzymes

Raha Pazoki, Marijana Vujkovic, Joshua Elliott, Evangelos Evangelou, Dipender Gill, ..., Shahpoor Shayan, Stacey B. Whitbourne, Jim L. Breeling, J. P. Casas Romero, Rachel B. Ramoni

Nature Communications   ·   10 May 2021   ·   doi:10.1038/s41467-021-22338-2

PubMed

Selected Work Complex Traits MASLD Consortia MVP

Multi-trait association studies discover pleiotropic loci between Alzheimer’s disease and cardiometabolic traits

William P. Bone, Katherine M. Siewert, Anupama Jha, Derek Klarin, Scott M. Damrauer, Kyong-Mi Chang, Philip S. Tsao, Themistocles L. Assimes, Marylyn D. Ritchie, Benjamin F. Voight

Alzheimer's Research & Therapy   ·   04 Feb 2021   ·   doi:10.1186/s13195-021-00773-z

PubMed

Selected Work Complex Traits Pleiotropy

Genetics of Smoking and Risk of Atherosclerotic Cardiovascular Diseases

Michael G. Levin, Derek Klarin, Themistocles L. Assimes, Matthew S. Freiberg, Erik Ingelsson, ..., Daniel J. Rader, Philip S. Tsao, Kyong-Mi Chang, Benjamin F. Voight, Scott M. Damrauer

JAMA Network Open   ·   19 Jan 2021   ·   doi:10.1001/jamanetworkopen.2020.34461

PubMed

Selected Work Complex Traits Mendelian Randomization CAD/CVD Pleiotropy Consortia MVP

Prioritizing the Role of Major Lipoproteins and Subfractions as Risk Factors for Peripheral Artery Disease

Michael G. Levin, Verena Zuber, Venexia M. Walker, Derek Klarin, Julie Lynch, ..., Philip S. Tsao, Benjamin F. Voight, Dipender Gill, Stephen Burgess, Scott M. Damrauer

Cold Spring Harbor Laboratory   ·   15 Jan 2021   ·   doi:10.1101/2021.01.11.21249148

Preprint Complex Traits Mendelian Randomization CAD/CVD Pleiotropy

Genome-wide association study implicates novel loci and reveals candidate effector genes for longitudinal pediatric bone accrual

Diana L. Cousminer, Yadav Wagley, James A. Pippin, Ahmed Elhakeem, Gregory P. Way, ..., Benjamin F. Voight, Andrew D. Wells, Babette S. Zemel, Kurt D. Hankenson, Struan F. A. Grant

Genome Biology   ·   04 Jan 2021   ·   doi:10.1186/s13059-020-02207-9

PubMed

Complex Traits Collaborative

A trans-ancestry genome-wide association study of unexplained chronic ALT elevation as a proxy for nonalcoholic fatty liver disease with histological and radiological validation

Marijana Vujkovic, Shweta Ramdas, Kimberly M. Lorenz, Xiuqing Guo, Rebecca Darlay, ..., Jerome I. Rotter, Julie A. Lynch, Daniel J. Rader, Benjamin F. Voight, Kyong-Mi Chang

Cold Spring Harbor Laboratory   ·   02 Jan 2021   ·   doi:10.1101/2020.12.26.20248491

Preprint Complex Traits MASLD Consortia MVP

2020

Golden orb-weaving spider (Trichonephila clavipes) silk genes with sex-biased expression and atypical architectures

Sandra M Correa-Garhwal, Paul L Babb, Benjamin F Voight, Cheryl Y Hayashi

G3 Genes|Genomes|Genetics   ·   22 Dec 2020   ·   doi:10.1093/G3JOURNAL/JKAA039

PubMed

Selected Work Pop Gen Spiders

Genetic Predisposition to Coronary Artery Disease in Type 2 Diabetes Mellitus

Natalie R. van Zuydam, Claes Ladenvall, Benjamin F. Voight, Rona J. Strawbridge, Juan Fernandez-Tajes, ..., Li-ming Gan, Everson Nogoceke, Piero Tortoli, Bernd Jablonka, Mary-Julia Brosnan

Circulation: Genomic and Precision Medicine   ·   01 Dec 2020   ·   doi:10.1161/CIRCGEN.119.002769

PubMed

Complex Traits T2D CAD/CVD Pleiotropy Collaborative

Mapping the genetic architecture of human traits to cell types in the kidney identifies mechanisms of disease and potential treatments

Xin Sheng, Ziyuan Ma, Junnan Wu, Hongbo Liu, Chengxiang Qiu, ..., Mingyao Li, Benjamin Voight, Thomas Coffman, Christopher D. Brown, Katalin Susztak

Cold Spring Harbor Laboratory   ·   10 Nov 2020   ·   doi:10.1101/2020.11.09.375592

Preprint Complex Traits QTL Mapping Collaborative

Genetics of height and risk of atrial fibrillation: A Mendelian randomization study

Michael G. Levin, Renae Judy, Dipender Gill, Marijana Vujkovic, Shefali S. Verma, ..., Matthew C. Hyman, Saman Nazarian, Daniel J. Rader, Benjamin F. Voight, Scott M. Damrauer

PLOS Medicine   ·   08 Oct 2020   ·   doi:10.1371/journal.pmed.1003288

PubMed

Selected Work Complex Traits Mendelian Randomization CAD/CVD

The relationship between circulating lipids and breast cancer risk: A Mendelian randomization study

Kelsey E. Johnson, Katherine M. Siewert, Derek Klarin, Scott M. Damrauer, Kyong-Mi Chang, Philip S. Tsao, Themistocles L. Assimes, Kara N. Maxwell, Benjamin F. Voight

PLOS Medicine   ·   11 Sep 2020   ·   doi:10.1371/journal.pmed.1003302

PubMed

Complex Traits Mendelian Randomization CAD/CVD

Multi-trait association studies discover pleiotropic loci between Alzheimer’s disease and cardiometabolic traits

William P. Bone, Katherine M. Siewert, Anupama Jha, Derek Klarin, Scott M. Damrauer, Kyong-Mi Chang, Philip S. Tsao, Themistocles L. Assimes, Marylyn D. Ritchie, Benjamin F. Voight

Cold Spring Harbor Laboratory   ·   01 Sep 2020   ·   doi:10.1101/2020.08.26.20179366

Preprint Complex Traits Pleiotropy

Validating a non-invasive, ALT-based non-alcoholic fatty liver phenotype in the million veteran program

Marina Serper, Marijana Vujkovic, David E. Kaplan, Rotonya M. Carr, Kyung Min Lee, ..., Scott M. Damrauer, Julie A. Lynch, Danish Saleheen, Benjamin F. Voight, Kyong-Mi Chang

PLOS ONE   ·   25 Aug 2020   ·   doi:10.1371/journal.pone.0237430

PubMed

Selected Work Complex Traits MASLD Consortia MVP

Genetic Variation in Blood Pressure and Lifetime Risk of Peripheral Artery Disease: A Mendelian Randomization Study

Michael G. Levin, Derek Klarin, Venexia M. Walker, Dipender Gill, Julie Lynch, ..., Neil M. Davies, Philip S. Tsao, Kyong-Mi Chang, Benjamin F. Voight, Scott M. Damrauer

Cold Spring Harbor Laboratory   ·   25 Aug 2020   ·   doi:10.1101/2020.08.23.20180240

Preprint Complex Traits Mendelian Randomization CAD/CVD Pleiotropy Consortia MVP

Genetic determinants of increased body mass index mediate the effect of smoking on increased risk for type 2 diabetes but not coronary artery disease

Christopher S Thom, Zhuoran Ding, Michael G Levin, Scott M Damrauer, Kyung Min Lee, ..., Themistocles L Assimes, Yan V Sun, Christopher J O’Donnell, Marijana Vujkovic, Benjamin F Voight

Human Molecular Genetics   ·   24 Aug 2020   ·   doi:10.1093/hmg/ddaa193

PubMed

Selected Work Complex Traits Mendelian Randomization Pleiotropy

Type 1 diabetes in Africa: an immunogenetic study in the Amhara of North-West Ethiopia

Shitaye A. Balcha, Abayneh G. Demisse, Rajashree Mishra, Tanwi Vartak, Diana L. Cousminer, ..., Alistair J. K. Williams, Struan F. A. Grant, R. David Leslie, David I. W. Phillips, Elisabeth R. Trimble

Diabetologia   ·   23 Jul 2020   ·   doi:10.1007/s00125-020-05229-x

PubMed

Complex Traits CAD/CVD Collaborative

Cis-regulatory architecture of human ESC-derived hypothalamic neuron differentiation aids in variant-to-gene mapping of relevant complex traits

Matthew C. Pahl, Claudia A. Doege, Kenyaita M. Hodge, Sheridan H. Littleton, Michelle E. Leonard, ..., Andrew D. Wells, Benjamin F. Voight, Rudolph L. Leibel, Diana L. Cousminer, Struan F.A. Grant

Cold Spring Harbor Laboratory   ·   06 Jul 2020   ·   doi:10.1101/2020.07.06.146951

Preprint Complex Traits Collaborative

Genetic colocalization atlas points to common regulatory sites and genes for hematopoietic traits and hematopoietic contributions to disease phenotypes

Christopher S. Thom, Benjamin F. Voight

BMC Medical Genomics   ·   29 Jun 2020   ·   doi:10.1186/s12920-020-00742-9

PubMed

Selected Work Complex Traits Pleiotropy

Discovery of 318 new risk loci for type 2 diabetes and related vascular outcomes among 1.4 million participants in a multi-ancestry meta-analysis

Marijana Vujkovic, Jacob M. Keaton, Julie A. Lynch, Donald R. Miller, Jin Zhou, ..., J. Michael Gaziano, Sumitra Muralidhar, Kyong-Mi Chang, Benjamin F. Voight, Danish Saleheen

Nature Genetics   ·   15 Jun 2020   ·   doi:10.1038/s41588-020-0637-y

PubMed

Selected Work Complex Traits T2D Consortia MVP

Genetically Determined Birthweight Associates With Atrial Fibrillation

Rachel L. Kember, Michael G. Levin, Diana L. Cousminer, Noah Tsao, Renae Judy, ..., Shana E. McCormack, Struan F.A. Grant, Daniel J. Rader, Benjamin F. Voight, Scott M. Damrauer

Circulation: Genomic and Precision Medicine   ·   01 Jun 2020   ·   doi:10.1161/CIRCGEN.119.002553

PubMed

Selected Work Complex Traits Mendelian Randomization CAD/CVD Pleiotropy Consortia MVP

Identifying non-identical-by-descent rare variants in population-scale whole genome sequencing data

Kelsey E. Johnson, Benjamin F. Voight

Cold Spring Harbor Laboratory   ·   28 May 2020   ·   doi:10.1101/2020.05.26.117358

GitHub

Preprint Pop Gen Mutation Rate AI/ML Methods Development Software

Tropomyosin 1 genetically constrains in vitro hematopoiesis

Christopher Stephen Thom, Chintan D Jobaliya, Kimberly Lorenz, Jean Ann Maguire, Alyssa Gagne, Paul Gadue, Deborah L French, Benjamin Franklin Voight

BMC Biology   ·   14 May 2020   ·   doi:10.1186/s12915-020-00783-7

PubMed

Selected Work Complex Traits Pleiotropy AI/ML

Cross-trait analyses with migraine reveal widespread pleiotropy and suggest a vascular component to migraine headache

Katherine M Siewert, Derek Klarin, Scott M Damrauer, Kyong-Mi Chang, Philip S Tsao, ..., Benjamin M Neale, Jes Olesen, Daniel I Chasman, Dale R Nyholt, Aarno Palotie

International Journal of Epidemiology   ·   19 Apr 2020   ·   doi:10.1093/IJE/DYAA050

PubMed

Complex Traits Mendelian Randomization CAD/CVD Pleiotropy

A missense variant in Mitochondrial Amidoxime Reducing Component 1 gene and protection against liver disease

Connor A. Emdin, Mary E. Haas, Amit V. Khera, Krishna Aragam, Mark Chaffin, ..., Craig Hanis, Mark Daly, Joshua Denny, Stacey Gabriel, Sekar Kathiresan

PLOS Genetics   ·   13 Apr 2020   ·   doi:10.1371/journal.pgen.1008629

PubMed

Complex Traits MASLD Consortia Collaborative MVP

Genetics of Smoking and Risk of Atherosclerotic Cardiovascular Diseases: A Mendelian Randomization Study

Michael G. Levin, Derek Klarin, Themistocles L. Assimes, Matthew S. Freiberg, Erik Ingelsson, ..., Daniel J. Rader, Philip S. Tsao, Kyong-Mi Chang, Benjamin F. Voight, Scott M. Damrauer

Cold Spring Harbor Laboratory   ·   08 Apr 2020   ·   doi:10.1101/2020.04.07.20053447

Preprint Complex Traits Mendelian Randomization CAD/CVD Consortia MVP

Genome-wide association study implicates novel loci and reveals candidate effector genes for longitudinal pediatric bone accrual through variant-to-gene mapping

Diana L. Cousminer, Yadav Wagley, James A. Pippin, Ahmed Elhakeem, Gregory P. Way, ..., Benjamin F. Voight, Andrew D. Wells, Babette S. Zemel, Kurt Hankenson, Struan F. A. Grant

Cold Spring Harbor Laboratory   ·   20 Feb 2020   ·   doi:10.1101/2020.02.17.20024133

Preprint Complex Traits Collaborative

Genetically determined body mass index mediates the effect of smoking on type 2 diabetes risk, but not coronary artery disease risk

Christopher S Thom, Zhuoran Ding, Michael G Levin, Scott M Damrauer, Benjamin F Voight

Cold Spring Harbor Laboratory   ·   03 Feb 2020   ·   doi:10.1101/2020.01.30.20019737

Preprint Complex Traits Mendelian Randomization Pleiotropy

BetaScan2: Standardized Statistics to Detect Balancing Selection Utilizing Substitution Data

Katherine M Siewert, Benjamin F Voight

Genome Biology and Evolution   ·   01 Feb 2020   ·   doi:10.1093/gbe/evaa013

PubMed

GitHub

Selected Work Pop Gen Selection Statistics Methods Development Software

2019

Genetics of Height and Risk of Atrial Fibrillation: A Mendelian Randomization Study

Michael G. Levin, Renae Judy, Dipender Gill, Marijana Vujkovic, Matthew C. Hyman, Saman Nazarian, Daniel J. Rader, Benjamin F. Voight, Scott M. Damrauer

Cold Spring Harbor Laboratory   ·   30 Dec 2019   ·   doi:10.1101/2019.12.23.19015743

Preprint Complex Traits Mendelian Randomization CAD/CVD

Genetic Discrimination Between LADA and Childhood-Onset Type 1 Diabetes Within the MHC

Rajashree Mishra, Mikael Åkerlund, Diana L. Cousminer, Emma Ahlqvist, Jonathan P. Bradfield, ..., Stanley Schwartz, Bernhard O. Boehm, Leif Groop, Richard David Leslie, Struan F.A. Grant

Diabetes Care   ·   16 Dec 2019   ·   doi:10.2337/dc19-0986

PubMed

Complex Traits T1D Collaborative

Discovery of 318 novel loci for type-2 diabetes and related micro- and macrovascular outcomes among 1.4 million participants in a multi-ethnic meta-analysis

Marijana Vujkovic, Jacob M. Keaton, Julie A. Lynch, Donald R. Miller, Jin Zhou, ..., Christopher J. O’Donnell, Philip S. Tsao, Kyong-Mi Chang, Benjamin F. Voight, Danish Saleheen

Cold Spring Harbor Laboratory   ·   25 Nov 2019   ·   doi:10.1101/19012690

Preprint Complex Traits T2D Consortia MVP

Natural human genetic variation determines basal and inducible expression of PM20D1 , an obesity-associated gene

Kiara K. Benson, Wenxiang Hu, Angela H. Weller, Alexis H. Bennett, Eric R. Chen, ..., William P. Bone, Lin Wang, Joshua D. Rabinowitz, Benjamin F. Voight, Raymond E. Soccio

Proceedings of the National Academy of Sciences   ·   28 Oct 2019   ·   doi:10.1073/pnas.1913199116

PubMed

Complex Traits Collaborative

Assessing a causal relationship between circulating lipids and breast cancer risk: Mendelian randomization study

Kelsey E. Johnson, Katherine M. Siewert, Derek Klarin, Scott M. Damrauer, Kyong-Mi Chang, Philip S. Tsao, Themistocles L. Assimes, Kara N. Maxwell, Benjamin F. Voight

Cold Spring Harbor Laboratory   ·   06 Oct 2019   ·   doi:10.1101/794594

Preprint Complex Traits Mendelian Randomization Pleiotropy

Genetic colocalization atlas points to common regulatory sites and genes for hematopoietic traits and hematopoietic contributions to disease phenotypes

CS Thom, BF Voight

Cold Spring Harbor Laboratory   ·   30 Sep 2019   ·   doi:10.1101/787333

Preprint Complex Traits Pleiotropy

Projected Prevalence of Actionable Pharmacogenetic Variants and Level A Drugs Prescribed Among US Veterans Health Administration Pharmacy Users

Catherine Chanfreau-Coffinier, Leland E. Hull, Julie A. Lynch, Scott L. DuVall, Scott M. Damrauer, ..., Benjamin F. Voight, Michael E. Matheny, David W. Oslin, Michael S. Icardi, Sony Tuteja

JAMA Network Open   ·   07 Jun 2019   ·   doi:10.1001/jamanetworkopen.2019.5345

PubMed

Complex Traits MASLD Consortia MVP

Evaluating the contribution of cell-type specific alternative splicing to variation in lipid levels

K.A.B. Gawronski, W. Bone, Y. Park, E. Pashos, X. Wang, W. Yang, D. Rader, K. Musunuru, B. Voight, C. Brown

Cold Spring Harbor Laboratory   ·   04 Jun 2019   ·   doi:10.1101/659326

Preprint Complex Traits QTL Mapping

Tropomyosin 1 genetically constrains in vitro hematopoiesis

CS Thom, CD Jobaliya, K Lorenz, JA Maguire, A Gagne, P Gadue, DL French, BF Voight

Cold Spring Harbor Laboratory   ·   08 May 2019   ·   doi:10.1101/631895

Preprint Complex Traits Pleiotropy AI/ML

Postmenopausal osteoporotic fracture-associated COLIA1 variant impacts bone accretion in girls

Diana L. Cousminer, Shana E. McCormack, Jonathan A. Mitchell, Alessandra Chesi, Joseph M. Kindler, ..., John A. Shepherd, Sharon E. Oberfield, Vicente Gilsanz, Babette S. Zemel, Struan F.A. Grant

Bone   ·   01 Apr 2019   ·   doi:10.1016/j.bone.2019.01.026

PubMed

Complex Traits Collaborative

Signals of Variation in Human Mutation Rate at Multiple Levels of Sequence Context

Rachael C Aikens, Kelsey E Johnson, Benjamin F Voight

Molecular Biology and Evolution   ·   07 Feb 2019   ·   doi:10.1093/molbev/msz023

PubMed

Selected Work Pop Gen Mutation Rate

Keen on the tenure track job, are you? Know these things, you should

Benjamin F. Voight

Genome Biology   ·   07 Jan 2019   ·   doi:10.1186/s13059-018-1617-8

PubMed

Selected Work Opinion/Review/Book Chapter

2018

BetaScan2: Standardized statistics to detect balancing selection utilizing substitution data:

Katherine M Siewert, Benjamin F Voight

Cold Spring Harbor Laboratory   ·   17 Dec 2018   ·   doi:10.1101/497255

GitHub

Preprint Pop Gen Selection Statistics Methods Development Software

Bivariate Genome-Wide Association Scan Identifies 6 Novel Loci Associated With Lipid Levels and Coronary Artery Disease

Katherine M. Siewert, Benjamin F. Voight

Circulation: Genomic and Precision Medicine   ·   01 Dec 2018   ·   doi:10.1161/CIRCGEN.118.002239

PubMed

Selected Work Complex Traits CAD/CVD Pleiotropy

First Genome-Wide Association Study of Latent Autoimmune Diabetes in Adults Reveals Novel Insights Linking Immune and Metabolic Diabetes

Diana L. Cousminer, Emma Ahlqvist, Rajashree Mishra, Mette K. Andersen, Alessandra Chesi, ..., Joan M. Lappe, John A. Shepherd, Sharon E. Oberfield, Vicente Gilsanz, Babette S. Zemel

Diabetes Care   ·   15 Oct 2018   ·   doi:10.2337/dc18-1032

PubMed

Complex Traits T1D Pleiotropy Collaborative

Signals of variation in human mutation rate at multiple levels of sequence context

Rachael C. Aikens, Kelsey E. Johnson, Benjamin F. Voight

Cold Spring Harbor Laboratory   ·   04 Aug 2018   ·   doi:10.1101/385096

Preprint Pop Gen Mutation Rate

Multiplexed Targeted Resequencing Identifies Coding and Regulatory Variation Underlying Phenotypic Extremes of High-Density Lipoprotein Cholesterol in Humans

Sumeet A. Khetarpal, Paul L. Babb, Wei Zhao, William F. Hancock-Cerutti, Christopher D. Brown, Daniel J. Rader, Benjamin F. Voight

Circulation: Genomic and Precision Medicine   ·   01 Jul 2018   ·   doi:10.1161/CIRCGEN.117.002070

PubMed

Selected Work Complex Traits CAD/CVD

Dissecting an adiposity locus with an arsenal of genomics

Kim Lorenz, Benjamin F. Voight

Genome Biology   ·   07 Jun 2018   ·   doi:10.1186/s13059-018-1460-y

PubMed

Opinion/Review/Book Chapter

Bivariate GWAS scan identifies six novel loci associated with lipid levels and coronary artery disease

Katherine M. Siewert, Benjamin F. Voight

Cold Spring Harbor Laboratory   ·   11 May 2018   ·   doi:10.1101/319848

Preprint Complex Traits CAD/CVD Pleiotropy

Patterns of shared signatures of recent positive selection across human populations

Kelsey Elizabeth Johnson, Benjamin F. Voight

Nature Ecology & Evolution   ·   19 Feb 2018   ·   doi:10.1038/s41559-018-0478-6

PubMed

Selected Work Pop Gen Selection Statistics Methods Development Software

2017

Sequence data and association statistics from 12,940 type 2 diabetes cases and controls

Jason Flannick, Christian Fuchsberger, Anubha Mahajan, Tanya M. Teslovich, Vineeta Agarwala, ..., David Altshuler, Noël P. Burtt, Jose C. Florez, Michael Boehnke, Mark I. McCarthy

Scientific Data   ·   19 Dec 2017   ·   doi:10.1038/sdata.2017.179

PubMed

Complex Traits T2D

Multiplexed targeted resequencing identifies coding and regulatory variation underlying phenotypic extremes of HDL-cholesterol in humans

Sumeet A. Khetarpal, Paul L. Babb, Wei Zhao, William F. Hancock-Cerutti, Christopher D. Brown, Daniel J. Rader, Benjamin F. Voight

Cold Spring Harbor Laboratory   ·   18 Dec 2017   ·   doi:10.1101/235887

Preprint Complex Traits CAD/CVD

Genetically Determined Later Puberty Impacts Lowered Bone Mineral Density in Childhood and Adulthood

Diana L Cousminer, Jonathan A Mitchell, Alessandra Chesi, Sani M Roy, Heidi J Kalkwarf, ..., Andrea Kelly, Shana E McCormack, Benjamin F Voight, Babette S Zemel, Struan FA Grant

Journal of Bone and Mineral Research   ·   25 Oct 2017   ·   doi:10.1002/jbmr.3320

PubMed

Complex Traits Collaborative

Identification of new susceptibility loci for type 2 diabetes and shared etiological pathways with coronary heart disease

Wei Zhao, Asif Rasheed, Emmi Tikkanen, Jung-Jin Lee, Adam S Butterworth, ..., Veikko Salomaa, Daniel J Rader, John Danesh, Benjamin F Voight, Danish Saleheen

Nature Genetics   ·   04 Sep 2017   ·   doi:10.1038/ng.3943

PubMed

Selected Work Complex Traits T2D CAD/CVD Pleiotropy

Detecting Long-Term Balancing Selection Using Allele Frequency Correlation

Katherine M. Siewert, Benjamin F. Voight

Molecular Biology and Evolution   ·   21 Jul 2017   ·   doi:10.1093/molbev/msx209

PubMed

GitHub

Selected Work Pop Gen Selection Statistics Methods Development Software

An Expanded Genome-Wide Association Study of Type 2 Diabetes in Europeans

Robert A. Scott, Laura J. Scott, Reedik Mägi, Letizia Marullo, Kyle J. Gaulton, ..., Josée Dupuis, Andrew P. Morris, Michael Boehnke, Mark I. McCarthy, Inga Prokopenko

Diabetes   ·   31 May 2017   ·   doi:10.2337/db16-1253

PubMed

Complex Traits T2D Collaborative

Gene Set Enrichment Analyses: lessons learned from the heart failure phenotype

Vinicius Tragante, Johannes M. I. H. Gho, Janine F. Felix, Ramachandran S. Vasan, Nicholas L. Smith, Benjamin F. Voight, Colin Palmer, Pim van der Harst, Jason H. Moore, Folkert W. Asselbergs

BioData Mining   ·   26 May 2017   ·   doi:10.1186/s13040-017-0137-5

PubMed

Complex Traits CAD/CVD Collaborative

The Nephila clavipes genome highlights the diversity of spider silk genes and their complex expression

Paul L Babb, Nicholas F Lahens, Sandra M Correa-Garhwal, David N Nicholson, Eun Ji Kim, ..., Matjaž Kuntner, Linden Higgins, Cheryl Y Hayashi, Ingi Agnarsson, Benjamin F Voight

Nature Genetics   ·   01 May 2017   ·   doi:10.1038/ng.3852

PubMed

Selected Work Pop Gen Spiders

Relative contribution of type 1 and type 2 diabetes loci to the genetic etiology of adult-onset, non-insulin-requiring autoimmune diabetes

Rajashree Mishra, Alessandra Chesi, Diana L. Cousminer, Mohammad I. Hawa, Jonathan P. Bradfield, ..., Benjamin F. Voight, Stanley Schwartz, Bernhard O. Boehm, Richard David Leslie, Struan F. A. Grant

BMC Medicine   ·   25 Apr 2017   ·   doi:10.1186/s12916-017-0846-0

PubMed

Complex Traits T2D T1D Pleiotropy Collaborative

Large-Scale trans -eQTLs Affect Hundreds of Transcripts and Mediate Patterns of Transcriptional Co-regulation

Boel Brynedal, JinMyung Choi, Towfique Raj, Robert Bjornson, Barbara E. Stranger, Benjamin M. Neale, Benjamin F. Voight, Chris Cotsapas

The American Journal of Human Genetics   ·   01 Apr 2017   ·   doi:10.1016/j.ajhg.2017.02.004

PubMed

Complex Traits QTL Mapping Pleiotropy Collaborative

Detecting Long-term Balancing Selection using Allele Frequency Correlation

Katherine M. Siewert, Benjamin F. Voight

Cold Spring Harbor Laboratory   ·   01 Mar 2017   ·   doi:10.1101/112870

GitHub

Preprint Pop Gen Selection Statistics Methods Development Software

Patterns of shared signatures of recent positive selection across human populations

Kelsey Elizabeth Johnson, Benjamin F. Voight

Cold Spring Harbor Laboratory   ·   17 Feb 2017   ·   doi:10.1101/109371

Preprint Pop Gen Selection Statistics Methods Development Software

De novo mutational profile in RB1 clarified using a mutation rate modeling algorithm

Varun Aggarwala, Arupa Ganguly, Benjamin F. Voight

BMC Genomics   ·   14 Feb 2017   ·   doi:10.1186/s12864-017-3522-z

PubMed

Selected Work Complex Traits Mutation Rate Statistics Methods Development

2016

Serum calcium and risk of migraine: a Mendelian randomization study

Peter Yin, Verneri Anttila, Katherine M. Siewert, Aarno Palotie, George Davey Smith, Benjamin F. Voight

Human Molecular Genetics   ·   26 Dec 2016   ·   doi:10.1093/hmg/ddw416

PubMed

Selected Work Complex Traits Mendelian Randomization Pleiotropy

Type 2 Diabetes Genes Gleaned by Making a β-Cell Screen Routine

Benjamin F. Voight, Struan F.A. Grant

Diabetes   ·   12 Nov 2016   ·   doi:10.2337/dbi16-0054

PubMed

Opinion/Review/Book Chapter

Assessing the general population frequency of rare coding variants in the EXT1 and EXT2 genes previously implicated in hereditary multiple exostoses

Diana L. Cousminer, Alexandre Arkader, Benjamin F. Voight, Maurizio Pacifici, Struan F.A. Grant

Bone   ·   01 Nov 2016   ·   doi:10.1016/j.bone.2016.09.005

PubMed

Complex Traits

Systolic Blood Pressure and Risk of Type 2 Diabetes: A Mendelian Randomization Study

Rachael C. Aikens, Wei Zhao, Danish Saleheen, Muredach P. Reilly, Stephen E. Epstein, Emmi Tikkanen, Veikko Salomaa, Benjamin F. Voight

Diabetes   ·   04 Oct 2016   ·   doi:10.2337/db16-0868

PubMed

Selected Work Complex Traits Mendelian Randomization T2D Pleiotropy

The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals

Georg B Ehret, Teresa Ferreira, Daniel I Chasman, Anne U Jackson, Ellen M Schmidt, ..., Aravinda Chakravarti, Panos Deloukas, Andrew P Morris, Christopher Newton-Cheh, Patricia B Munroe

Nature Genetics   ·   12 Sep 2016   ·   doi:10.1038/ng.3667

PubMed

Complex Traits Collaborative

Disentangling the Causal Association of Plasma Lipid Traits and Type 2 Diabetes Using Human Genetics

Danish Saleheen, Daniel J. Rader, Benjamin F. Voight

JAMA Cardiology   ·   01 Sep 2016   ·   doi:10.1001/jamacardio.2016.2298

PubMed

Opinion/Review/Book Chapter

The genetic architecture of type 2 diabetes

Christian Fuchsberger, Jason Flannick, Tanya M. Teslovich, Anubha Mahajan, Vineeta Agarwala, ..., Andrew P. Morris, Hyun Min Kang, Michael Boehnke, David Altshuler, Mark I. McCarthy

Nature   ·   11 Jul 2016   ·   doi:10.1038/nature18642

PubMed

Complex Traits T2D Consortia Collaborative

Pathway and network-based strategies to translate genetic discoveries into effective therapies

Casey S. Greene, Benjamin F. Voight

Human Molecular Genetics   ·   23 Jun 2016   ·   doi:10.1093/hmg/ddw160

PubMed

Opinion/Review/Book Chapter

Large-scaletrans-eQTLs affect hundreds of transcripts and mediate patterns of transcriptional co-regulation Short:trans-eQTLs reveal patterns of transcriptional co-regulation

Boel Brynedal, JinMyung Choi, Towfique Raj, Robert Bjornson, Barbara E Stranger, Benjamin M Neale, Benjamin F Voight, Chris Cotsapas

Cold Spring Harbor Laboratory   ·   31 May 2016   ·   doi:10.1101/056283

Preprint Complex Traits QTL Mapping Pleiotropy Collaborative

An expanded sequence context model broadly explains variability in polymorphism levels across the human genome

Varun Aggarwala, Benjamin F Voight

Nature Genetics   ·   15 Feb 2016   ·   doi:10.1038/ng.3511

PubMed

Selected Work Pop Gen Mutation Rate Statistics Methods Development

Human genetics shines a light on ischaemic stroke

Benjamin F Voight, Daniel J Rader

The Lancet Neurology   ·   01 Feb 2016   ·   doi:10.1016/S1474-4422(15)00400-7

PubMed

Opinion/Review/Book Chapter

Causal Assessment of Serum Urate Levels in Cardiometabolic Diseases Through a Mendelian Randomization Study

Tanya Keenan, Wei Zhao, Asif Rasheed, Weang K. Ho, Rainer Malik, ..., Muredach P. Reilly, John Danesh, Daniel J. Rader, Benjamin F. Voight, Danish Saleheen

Journal of the American College of Cardiology   ·   01 Feb 2016   ·   doi:10.1016/j.jacc.2015.10.086

PubMed

Selected Work Complex Traits Mendelian Randomization T2D CAD/CVD Pleiotropy

Causal Inference in Medicine via Mendelian Randomization

Timothy M. Frayling, Benjamin F. Voight

The Genetics of Type 2 Diabetes and Related Traits   ·   01 Jan 2016   ·   doi:10.1007/978-3-319-01574-3_24

Selected Work Complex Traits Mendelian Randomization Opinion/Review/Book Chapter

2015

Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci

Kyle J Gaulton, Teresa Ferreira, Yeji Lee, Anne Raimondo, Reedik Mägi, ..., David Altshuler, Michael Boehnke, Tanya M Teslovich, Mark I McCarthy, Andrew P Morris

Nature Genetics   ·   09 Nov 2015   ·   doi:10.1038/ng.3437

PubMed

Complex Traits T2D

Genetic variants primarily associated with type 2 diabetes are related to coronary artery disease risk

Henning Jansen, Christina Loley, Wolfgang Lieb, Michael J. Pencina, Christopher P. Nelson, ..., Inke R. König, Ramachandran S. Vasan, Jeanette Erdmann, Nilesh J. Samani, Heribert Schunkert

Atherosclerosis   ·   01 Aug 2015   ·   doi:10.1016/j.atherosclerosis.2015.05.033

PubMed

Complex Traits T2D CAD/CVD Collaborative

Genetic Variation Determines PPARγ Function and Anti-diabetic Drug Response In Vivo

Raymond E. Soccio, Eric R. Chen, Satyajit R. Rajapurkar, Pegah Safabakhsh, Jill M. Marinis, ..., David J. Steger, Ying Wu, Mete Civelek, Benjamin F. Voight, Mitchell A. Lazar

Cell   ·   01 Jul 2015   ·   doi:10.1016/j.cell.2015.06.025

PubMed

Complex Traits T2D Collaborative

2014

MeRP: a high-throughput pipeline for Mendelian randomization analysis

Peter Yin, Benjamin F. Voight

Bioinformatics   ·   10 Nov 2014   ·   doi:10.1093/bioinformatics/btu742

PubMed

Complex Traits Mendelian Randomization Automation Methods Development Software

MR_predictor: a simulation engine for Mendelian Randomization studies

Benjamin F. Voight

Bioinformatics   ·   26 Aug 2014   ·   doi:10.1093/bioinformatics/btu564

PubMed

GitHub

Selected Work Complex Traits Mendelian Randomization Statistics Methods Development Software

Pleiotropic genes for metabolic syndrome and inflammation

Aldi T. Kraja, Daniel I. Chasman, Kari E. North, Alexander P. Reiner, Lisa R. Yanek, ..., Emelia J. Benjamin, Behrooz Z. Alizadeh, Inga Prokopenko, James B. Meigs, Ingrid B. Borecki

Molecular Genetics and Metabolism   ·   01 Aug 2014   ·   doi:10.1016/j.ymgme.2014.04.007

PubMed

Complex Traits Pleiotropy Consortia Collaborative

A Central Role for GRB10 in Regulation of Islet Function in Man

Inga Prokopenko, Wenny Poon, Reedik Mägi, Rashmi Prasad B, S. Albert Salehi, ..., Alan R. Shuldiner, Kristi D. Silver, Markku Laakso, Leif Groop, Valeriya Lyssenko

PLoS Genetics   ·   03 Apr 2014   ·   doi:10.1371/journal.pgen.1004235

PubMed

Complex Traits T2D Collaborative

Guidelines for investigating causality of sequence variants in human disease

D. G. MacArthur, T. A. Manolio, D. P. Dimmock, H. L. Rehm, J. Shendure, ..., S. R. Sunyaev, D. Valle, B. F. Voight, W. Winckler, C. Gunter

Nature   ·   01 Apr 2014   ·   doi:10.1038/nature13127

PubMed

Selected Work Complex Traits Collaborative Opinion/Review/Book Chapter

SORT ing Out That Pesky Cholesterol

Benjamin F. Voight

Science Translational Medicine   ·   05 Mar 2014   ·   doi:10.1126/scitranslmed.3008715

Opinion/Review/Book Chapter

Loss-of-function mutations in SLC30A8 protect against type 2 diabetes

Jason Flannick, Gudmar Thorleifsson, Nicola L Beer, Suzanne B R Jacobs, Niels Grarup, ..., Oluf Pedersen, Leif Groop, David R Cox, Kari Stefansson, David Altshuler

Nature Genetics   ·   02 Mar 2014   ·   doi:10.1038/ng.2915

PubMed

Selected Work Complex Traits T2D Consortia Collaborative

Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility

Anubha Mahajan, Min Jin Go, Weihua Zhang, Jennifer E Below, Kyle J Gaulton, ..., Esteban J Parra, John C Chambers, E Shyong Tai, Mark I McCarthy, Andrew P Morris

Nature Genetics   ·   09 Feb 2014   ·   doi:10.1038/ng.2897

PubMed

Complex Traits T2D Consortia Collaborative

A Metabolic Relic

Benjamin F. Voight

Science Translational Medicine   ·   22 Jan 2014   ·   doi:10.1126/scitranslmed.3008436

Opinion/Review/Book Chapter

2013

Right Place, Right Time

Benjamin F. Voight

Science Translational Medicine   ·   04 Dec 2013   ·   doi:10.1126/scitranslmed.3008007

Opinion/Review/Book Chapter

Thinking Before We Act

Benjamin F. Voight

Science Translational Medicine   ·   23 Oct 2013   ·   doi:10.1126/scitranslmed.3007770

Opinion/Review/Book Chapter

Discovery and refinement of loci associated with lipid levels

[no author info]

Nature Genetics   ·   06 Oct 2013   ·   doi:10.1038/ng.2797

PubMed

Complex Traits Pleiotropy Consortia Collaborative

Common variants associated with plasma triglycerides and risk for coronary artery disease

Ron Do, Cristen J Willer, Ellen M Schmidt, Sebanti Sengupta, Chi Gao, ..., Erik Ingelsson, Goncalo R Abecasis, Mark J Daly, Benjamin M Neale, Sekar Kathiresan

Nature Genetics   ·   06 Oct 2013   ·   doi:10.1038/ng.2795

PubMed

Complex Traits CAD/CVD Pleiotropy Collaborative

Ironing Out Parkinson’s Disease

Benjamin F. Voight

Science Translational Medicine   ·   31 Jul 2013   ·   doi:10.1126/scitranslmed.3007047

Opinion/Review/Book Chapter

RA- cing Toward Drugs from a Genetics Starting Line

Benjamin F. Voight

Science Translational Medicine   ·   19 Jun 2013   ·   doi:10.1126/scitranslmed.3006750

Opinion/Review/Book Chapter

From Mouse to Human: Evolutionary Genomics Analysis of Human Orthologs of Essential Genes

Benjamin Georgi, Benjamin F. Voight, Maja Bućan

PLoS Genetics   ·   09 May 2013   ·   doi:10.1371/journal.pgen.1003484

PubMed

Selected Work Pop Gen Selection

Eavesdropping on Communications Between Liver and β Cells

Benjamin F. Voight

Science Translational Medicine   ·   08 May 2013   ·   doi:10.1126/scitranslmed.3006452

Opinion/Review/Book Chapter

Accessing the Inaccessible Genome

Benjamin F. Voight

Science Translational Medicine   ·   03 Apr 2013   ·   doi:10.1126/scitranslmed.3006206

Opinion/Review/Book Chapter

2012

Large-scale association analysis identifies new risk loci for coronary artery disease

Panos Deloukas, Stavroula Kanoni, Christina Willenborg, Martin Farrall, Themistocles L Assimes, ..., Colin N A Palmer, Robert Roberts, Hugh Watkins, Heribert Schunkert, Nilesh J Samani

Nature Genetics   ·   02 Dec 2012   ·   doi:10.1038/ng.2480

PubMed

Complex Traits CAD/CVD Consortia Collaborative

Identification of the BCAR1-CFDP1-TMEM170A Locus as a Determinant of Carotid Intima-Media Thickness and Coronary Artery Disease Risk

Karl Gertow, Bengt Sennblad, Rona J. Strawbridge, John Öhrvik, Delilah Zabaneh, ..., Damiano Baldassarre, Elena Tremoli, Ulf de Faire, Steve E. Humphries, Anders Hamsten

Circulation: Cardiovascular Genetics   ·   01 Dec 2012   ·   doi:10.1161/CIRCGENETICS.112.963660

PubMed

Complex Traits CAD/CVD Collaborative

Informed Conditioning on Clinical Covariates Increases Power in Case-Control Association Studies

Noah Zaitlen, Sara Lindström, Bogdan Pasaniuc, Marilyn Cornelis, Giulio Genovese, ..., David Altshuler, Benjamin Voight, Peter Kraft, Nick Patterson, Alkes L. Price

PLoS Genetics   ·   08 Nov 2012   ·   doi:10.1371/journal.pgen.1003032

PubMed

Complex Traits Collaborative

Human genetics offers an emerging picture of common pathways and mechanisms in autoimmunity

Benjamin F Voight, Chris Cotsapas

Current Opinion in Immunology   ·   01 Oct 2012   ·   doi:10.1016/j.coi.2012.07.013

PubMed

Opinion/Review/Book Chapter

Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes

Andrew P Morris, Benjamin F Voight, Tanya M Teslovich, Teresa Ferreira, Ayellet V Segrè, ..., Josée Dupuis, James B Meigs, David Altshuler, Michael Boehnke, Mark I McCarthy

Nature Genetics   ·   12 Aug 2012   ·   doi:10.1038/ng.2383

PubMed

Selected Work Complex Traits T2D Consortia Statistics

Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways

Robert A Scott, Vasiliki Lagou, Ryan P Welch, Eleanor Wheeler, May E Montasser, ..., Jose C Florez, Claudia Langenberg, Erik Ingelsson, Inga Prokopenko, Inês Barroso

Nature Genetics   ·   12 Aug 2012   ·   doi:10.1038/ng.2385

PubMed

Complex Traits T2D Collaborative

The Metabochip, a Custom Genotyping Array for Genetic Studies of Metabolic, Cardiovascular, and Anthropometric Traits

Benjamin F. Voight, Hyun Min Kang, Jun Ding, Cameron D. Palmer, Carlo Sidore, ..., Joel N. Hirschhorn, David Altshuler, Mark I. McCarthy, Gonçalo R. Abecasis, Michael Boehnke

PLoS Genetics   ·   02 Aug 2012   ·   doi:10.1371/journal.pgen.1002793

PubMed

Selected Work Complex Traits T2D CAD/CVD Pleiotropy Methods Development

Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study

Benjamin F Voight, Gina M Peloso, Marju Orho-Melander, Ruth Frikke-Schmidt, Maja Barbalic, ..., Daniel J Rader, Leena Peltonen, Stephen M Schwartz, David Altshuler, Sekar Kathiresan

The Lancet   ·   01 Aug 2012   ·   doi:10.1016/S0140-6736(12)60312-2

PubMed

PDF

News

Selected Work Complex Traits Mendelian Randomization CAD/CVD Pleiotropy Statistics

Impact of Common Variation in Bone-Related Genes on Type 2 Diabetes and Related Traits

Liana K. Billings, Yi-Hsiang Hsu, Rachel J. Ackerman, Josée Dupuis, Benjamin F. Voight, ..., James S. Pankow, David Karasik, James B. Meigs, Douglas P. Kiel, Jose C. Florez

Diabetes   ·   17 Jul 2012   ·   doi:10.2337/db11-1515

PubMed

Complex Traits T2D Pleiotropy Collaborative

Stratifying Type 2 Diabetes Cases by BMI Identifies Genetic Risk Variants in LAMA1 and Enrichment for Risk Variants in Lean Compared to Obese Cases

John R. B. Perry, Benjamin F. Voight, Loïc Yengo, Najaf Amin, Josée Dupuis, ..., Colin N. A. Palmer, Nicholas J. Wareham, Leif Groop, Timothy M. Frayling, Stéphane Cauchi

PLoS Genetics   ·   31 May 2012   ·   doi:10.1371/journal.pgen.1002741

PubMed

Selected Work Complex Traits T2D Pleiotropy

A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance

Alisa K Manning, Marie-France Hivert, Robert A Scott, Jonna L Grimsby, Nabila Bouatia-Naji, ..., Richard M Watanabe, Jose C Florez, Josée Dupuis, James B Meigs, Claudia Langenberg

Nature Genetics   ·   13 May 2012   ·   doi:10.1038/ng.2274

PubMed

Complex Traits Pleiotropy Consortia Collaborative

Analysis of case–control association studies with known risk variants

Noah Zaitlen, Bogdan Paşaniuc, Nick Patterson, Samuela Pollack, Benjamin Voight, ..., Christopher A. Haiman, Barbara E. Stranger, Emmanouil T. Dermitzakis, Peter Kraft, Alkes L. Price

Bioinformatics   ·   03 May 2012   ·   doi:10.1093/bioinformatics/bts259

PubMed

Complex Traits Collaborative

Meta-analysis identifies six new susceptibility loci for atrial fibrillation

Patrick T Ellinor, Kathryn L Lunetta, Christine M Albert, Nicole L Glazer, Marylyn D Ritchie, ..., Daniel I Chasman, Susan R Heckbert, Emelia J Benjamin, Vilmundur Gudnason, Stefan Kääb

Nature Genetics   ·   29 Apr 2012   ·   doi:10.1038/ng.2261

PubMed

Complex Traits CAD/CVD Collaborative

Evaluation of the Metabochip Genotyping Array in African Americans and Implications for Fine Mapping of GWAS-Identified Loci: The PAGE Study

Steven Buyske, Ying Wu, Cara L. Carty, Iona Cheng, Themistocles L. Assimes, ..., Karen L. Mohlke, Christopher A. Haiman, Ulrike Peters, Dana C. Crawford, Kari E. North

PLoS ONE   ·   23 Apr 2012   ·   doi:10.1371/journal.pone.0035651

PubMed

Complex Traits Pleiotropy

Patterns and rates of exonic de novo mutations in autism spectrum disorders

Benjamin M. Neale, Yan Kou, Li Liu, Avi Ma’ayan, Kaitlin E. Samocha, ..., Richard A. Gibbs, Kathryn Roeder, Gerard D. Schellenberg, James S. Sutcliffe, Mark J. Daly

Nature   ·   04 Apr 2012   ·   doi:10.1038/nature11011

PubMed

Complex Traits Mutation Rate Collaborative Statistics

Novel Loci for Adiponectin Levels and Their Influence on Type 2 Diabetes and Metabolic Traits: A Multi-Ethnic Meta-Analysis of 45,891 Individuals

Zari Dastani, Marie-France Hivert, Nicholas Timpson, John R. B. Perry, Xin Yuan, ..., Ruth J. F. Loos, Dawn M. Waterworth, James B. Meigs, Josee Dupuis, J. Brent Richards

PLoS Genetics   ·   29 Mar 2012   ·   doi:10.1371/journal.pgen.1002607

PubMed

Complex Traits Collaborative

Bayesian inference analyses of the polygenic architecture of rheumatoid arthritis

Eli A Stahl, Daniel Wegmann, Gosia Trynka, Javier Gutierrez-Achury, Ron Do, ..., Katherine A Siminovitch, Jane Worthington, Paul I W de Bakker, Soumya Raychaudhuri, Robert M Plenge

Nature Genetics   ·   25 Mar 2012   ·   doi:10.1038/ng.2232

PubMed

Complex Traits Pleiotropy Collaborative

Large-Scale Gene-Centric Meta-Analysis across 39 Studies Identifies Type 2 Diabetes Loci

Richa Saxena, Clara C. Elbers, Yiran Guo, Inga Peter, Tom R. Gaunt, ..., Alex Reiner, Donald W. Bowden, Hakon Hakonarson, David S. Siscovick, Brendan J. Keating

The American Journal of Human Genetics   ·   01 Mar 2012   ·   doi:10.1016/j.ajhg.2011.12.022

PubMed

Complex Traits T2D Consortia Collaborative

Single-Cell Analysis Reveals that Noncoding RNAs Contribute to Clonal Heterogeneity by Modulating Transcription Factor Recruitment

Stacie L. Bumgarner, Gregor Neuert, Benjamin F. Voight, Anna Symbor-Nagrabska, Paula Grisafi, Alexander van Oudenaarden, Gerald R. Fink

Molecular Cell   ·   01 Feb 2012   ·   doi:10.1016/j.molcel.2011.11.029

PubMed

Selected Work Collaborative

A Genome-Wide Association Search for Type 2 Diabetes Genes in African Americans

Nicholette D. Palmer, Caitrin W. McDonough, Pamela J. Hicks, Bong H. Roh, Maria R. Wing, ..., Charles N. Rotimi, Maggie C. Y. Ng, Carl D. Langefeld, Barry I. Freedman, Donald W. Bowden

PLoS ONE   ·   04 Jan 2012   ·   doi:10.1371/journal.pone.0029202

PubMed

Complex Traits T2D Collaborative

2011

Genome-Wide Association Study for Coronary Artery Calcification With Follow-Up in Myocardial Infarction

Christopher J. O'Donnell, Maryam Kavousi, Albert V. Smith, Sharon L.R. Kardia, Mary F. Feitosa, ..., Patricia A. Peyser, Ingrid B. Borecki, L. Adrienne Cupples, Vilmundur Gudnason, Jacqueline C.M. Witteman

Circulation   ·   01 Dec 2011   ·   doi:10.1161/CIRCULATIONAHA.110.974899

PubMed

Complex Traits CAD/CVD Consortia Collaborative

Genome-Wide Association Identifies Nine Common Variants Associated With Fasting Proinsulin Levels and Provides New Insights Into the Pathophysiology of Type 2 Diabetes

Rona J. Strawbridge, Josée Dupuis, Inga Prokopenko, Adam Barker, Emma Ahlqvist, ..., Richard M. Watanabe, Erik Ingelsson, Claudia Langenberg, Anders Hamsten, Jose C. Florez

Diabetes   ·   16 Sep 2011   ·   doi:10.2337/db11-0415

PubMed

Complex Traits T2D Consortia Collaborative

Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure

Louise V Wain, Germaine C Verwoert, Paul F O'Reilly, Gang Shi, Toby Johnson, ..., Mark J Caulfield, Dabeeru C Rao, Martin D Tobin, Paul Elliott, Cornelia M van Duijn

Nature Genetics   ·   11 Sep 2011   ·   doi:10.1038/ng.922

PubMed

Complex Traits Pleiotropy Collaborative

Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk

[no author info]

Nature   ·   11 Sep 2011   ·   doi:10.1038/nature10405

PubMed

Complex Traits MASLD Consortia Collaborative

Pervasive Sharing of Genetic Effects in Autoimmune Disease

Chris Cotsapas, Benjamin F. Voight, Elizabeth Rossin, Kasper Lage, Benjamin M. Neale, ..., Jane Worthington, John A. Todd, David A. Hafler, Stephen S. Rich, Mark J. Daly

PLoS Genetics   ·   10 Aug 2011   ·   doi:10.1371/journal.pgen.1002254

PubMed

GitHub

Selected Work Complex Traits Pleiotropy Statistics Methods Development Software

An Increased Burden of Common and Rare Lipid-Associated Risk Alleles Contributes to the Phenotypic Spectrum of Hypertriglyceridemia

Christopher T. Johansen, Jian Wang, Matthew B. Lanktree, Adam D. McIntyre, Matthew R. Ban, ..., Salim Yusuf, Murray W. Huff, Sekar Kathiresan, Henian Cao, Robert A. Hegele

Arteriosclerosis, Thrombosis, and Vascular Biology   ·   01 Aug 2011   ·   doi:10.1161/ATVBAHA.111.226365

PubMed

Complex Traits CAD/CVD

A Genome-Wide Association Study Identifies LIPA as a Susceptibility Gene for Coronary Artery Disease

Philipp S. Wild, Tanja Zeller, Arne Schillert, Silke Szymczak, Christoph R. Sinning, ..., Laurence Tiret, Veikko Salomaa, Thomas Munzel, Andreas Ziegler, Stefan Blankenberg

Circulation: Cardiovascular Genetics   ·   01 Aug 2011   ·   doi:10.1161/CIRCGENETICS.110.958728

PubMed

Complex Traits CAD/CVD

Influence of 9p21.3 Genetic Variants on Clinical and Angiographic Outcomes in Early-Onset Myocardial Infarction

Diego Ardissino, Carlo Berzuini, Piera Angelica Merlini, Pier Mannuccio Mannucci, Aarti Surti, ..., Alberto Piazza, Luisa Foco, Luisa Bernardinelli, David Altshuler, Sekar Kathiresan

Journal of the American College of Cardiology   ·   01 Jul 2011   ·   doi:10.1016/j.jacc.2010.11.075

PubMed

Complex Traits CAD/CVD Consortia Collaborative

Genome-Wide Association Analysis Identifies Variants Associated with Nonalcoholic Fatty Liver Disease That Have Distinct Effects on Metabolic Traits

Elizabeth K. Speliotes, Laura M. Yerges-Armstrong, Jun Wu, Ruben Hernaez, Lauren J. Kim, ..., Caroline S. Fox, Albert V. Smith, W. H. Linda Kao, Joel N. Hirschhorn, Ingrid B. Borecki

PLoS Genetics   ·   10 Mar 2011   ·   doi:10.1371/journal.pgen.1001324

PubMed

Complex Traits T2D Consortia Collaborative

Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease

Heribert Schunkert, Inke R König, Sekar Kathiresan, Muredach P Reilly, Themistocles L Assimes, ..., Robert Roberts, Unnur Thorsteinsdottir, Christopher J O'Donnell, Ruth McPherson, Jeanette Erdmann

Nature Genetics   ·   06 Mar 2011   ·   doi:10.1038/ng.784

PubMed

Complex Traits CAD/CVD Consortia Collaborative

Testing for an Unusual Distribution of Rare Variants

Benjamin M. Neale, Manuel A. Rivas, Benjamin F. Voight, David Altshuler, Bernie Devlin, Marju Orho-Melander, Sekar Kathiresan, Shaun M. Purcell, Kathryn Roeder, Mark J. Daly

PLoS Genetics   ·   03 Mar 2011   ·   doi:10.1371/journal.pgen.1001322

PubMed

Complex Traits Statistics Methods Development Software

Power in the phenotypic extremes: a simulation study of power in discovery and replication of rare variants

Lin T. Guey, Jasmina Kravic, Olle Melander, Noël P. Burtt, Jason M. Laramie, ..., Sekar Kathiresan, Leif Groop, Albert B. Seymour, David Altshuler, Benjamin F. Voight

Genetic Epidemiology   ·   09 Feb 2011   ·   doi:10.1002/gepi.20572

PubMed

Selected Work Complex Traits T2D Pleiotropy Statistics Methods Development

Delineating Signals from Association Studies

Benjamin F. Voight

Analysis of Complex Disease Association Studies   ·   01 Jan 2011   ·   doi:10.1016/B978-0-12-375142-3.10017-3

Complex Traits Opinion/Review/Book Chapter

2010

Lack of Association Between the Trp719Arg Polymorphism in Kinesin-Like Protein-6 and Coronary Artery Disease in 19 Case-Control Studies

Themistocles L. Assimes, Hilma Hólm, Sekar Kathiresan, Muredach P. Reilly, Gudmar Thorleifsson, ..., Unnur Thorsteinsdottir, Kari Stefansson, Heribert Schunkert, Nilesh J. Samani, Thomas Quertermous

Journal of the American College of Cardiology   ·   01 Nov 2010   ·   doi:10.1016/j.jacc.2010.06.022

PubMed

Complex Traits CAD/CVD Collaborative

Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution

Iris M Heid, Anne U Jackson, Joshua C Randall, Thomas W Winkler, Lu Qi, ..., Inês Barroso, Mark I McCarthy, Caroline S Fox, Karen L Mohlke, Cecilia M Lindgren

Nature Genetics   ·   10 Oct 2010   ·   doi:10.1038/ng.685

PubMed

Complex Traits Consortia Collaborative

Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index

Elizabeth K Speliotes, Cristen J Willer, Sonja I Berndt, Keri L Monda, Gudmar Thorleifsson, ..., Kari E North, Mark I McCarthy, Joel N Hirschhorn, Erik Ingelsson, Ruth J F Loos

Nature Genetics   ·   10 Oct 2010   ·   doi:10.1038/ng.686

PubMed

Complex Traits Consortia Collaborative

Design of the Coronary ARtery DIsease Genome-Wide Replication And Meta-Analysis (CARDIoGRAM) Study

Michael Preuss, Inke R. König, John R. Thompson, Jeanette Erdmann, Devin Absher, ..., Andreas Ziegler, Sekar Kathiresan, Muredach P. Reilly, Nilesh J. Samani, Heribert Schunkert

Circulation: Cardiovascular Genetics   ·   01 Oct 2010   ·   doi:10.1161/CIRCGENETICS.109.899443

PubMed

Complex Traits CAD/CVD Consortia Collaborative

Hundreds of variants clustered in genomic loci and biological pathways affect human height

Hana Lango Allen, Karol Estrada, Guillaume Lettre, Sonja I. Berndt, Michael N. Weedon, ..., Cecilia M. Lindgren, Gonçalo R. Abecasis, Kari Stefansson, Timothy M. Frayling, Joel N. Hirschhorn

Nature   ·   29 Sep 2010   ·   doi:10.1038/nature09410

PubMed

Complex Traits Consortia Collaborative

Common Variants at 10 Genomic Loci Influence Hemoglobin A1C Levels via Glycemic and Nonglycemic Pathways

Nicole Soranzo, Serena Sanna, Eleanor Wheeler, Christian Gieger, Dörte Radke, ..., Manjinder S. Sandhu, Matthew M. Heeney, Joseph M. Devaney, Muredach P. Reilly, Sally L. Ricketts

Diabetes   ·   21 Sep 2010   ·   doi:10.2337/db10-0502

PubMed

Complex Traits T2D Pleiotropy Consortia Collaborative

Multiethnic Genetic Association Studies Improve Power for Locus Discovery

Sara L. Pulit, Benjamin F. Voight, Paul I. W. de Bakker

PLoS ONE   ·   08 Sep 2010   ·   doi:10.1371/journal.pone.0012600

PubMed

Selected Work Complex Traits Pop Gen Statistics

PNPLA3 Variants Specifically Confer Increased Risk for Histologic Nonalcoholic Fatty Liver Disease But Not Metabolic Disease†,‡

Elizabeth K. Speliotes, Johannah L. Butler, Cameron D. Palmer, Benjamin F. Voight, Joel N. Hirschhorn

Hepatology   ·   01 Sep 2010   ·   doi:10.1002/hep.23768

PubMed

Complex Traits MASLD Consortia Collaborative

Biological, clinical and population relevance of 95 loci for blood lipids

Tanya M. Teslovich, Kiran Musunuru, Albert V. Smith, Andrew C. Edmondson, Ioannis M. Stylianou, ..., Cornelia M. van Duijn, Leena Peltonen, Gonçalo R. Abecasis, Michael Boehnke, Sekar Kathiresan

Nature   ·   01 Aug 2010   ·   doi:10.1038/nature09270

PubMed

Complex Traits Consortia Collaborative

Excess of rare variants in genes identified by genome-wide association study of hypertriglyceridemia

Christopher T Johansen, Jian Wang, Matthew B Lanktree, Henian Cao, Adam D McIntyre, ..., Sonia S Anand, Salim Yusuf, Murray W Huff, Sekar Kathiresan, Robert A Hegele

Nature Genetics   ·   25 Jul 2010   ·   doi:10.1038/ng.628

PubMed

Complex Traits CAD/CVD Collaborative

Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis

Benjamin F Voight, Laura J Scott, Valgerdur Steinthorsdottir, Andrew P Morris, Christian Dina, ..., Cornelia M van Duijn, Kari Stefansson, David Altshuler, Michael Boehnke, Mark I McCarthy

Nature Genetics   ·   27 Jun 2010   ·   doi:10.1038/ng.609

PubMed

Selected Work Complex Traits T2D Consortia

Genome-wide meta-analyses identify multiple loci associated with smoking behavior

[no author info]

Nature Genetics   ·   25 Apr 2010   ·   doi:10.1038/ng.571

PubMed

Complex Traits Consortia Collaborative

New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

Josée Dupuis, Claudia Langenberg, Inga Prokopenko, Richa Saxena, Nicole Soranzo, ..., Igor Rudan, Alan F Wright, Michael Stumvoll, Harry Campbell, James F Wilson

Nature Genetics   ·   17 Jan 2010   ·   doi:10.1038/ng.520

PubMed

Complex Traits T2D Pleiotropy Collaborative

Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge

Richa Saxena, Marie-France Hivert, Claudia Langenberg, Toshiko Tanaka, James S Pankow, ..., Gérard Waeber, Andrew Walley, Dawn M Waterworth, Eleftheria Zeggini, Jing Hua Zhao

Nature Genetics   ·   17 Jan 2010   ·   doi:10.1038/ng.521

PubMed

Complex Traits T2D Pleiotropy Collaborative

2009

A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium

Nicole Soranzo, Tim D Spector, Massimo Mangino, Brigitte Kühnel, Augusto Rendon, ..., Christa Meisinger, Andreas Greinacher, Panos Deloukas, Willem H Ouwehand, Christian Gieger

Nature Genetics   ·   11 Oct 2009   ·   doi:10.1038/ng.467

PubMed

Complex Traits Pleiotropy Consortia Collaborative

Underlying Genetic Models of Inheritance in Established Type 2 Diabetes Associations

Georgia Salanti, Lorraine Southam, David Altshuler, Kristin Ardlie, Inês Barroso, ..., Laura J. Scott, Benjamin F. Voight, Nicholas J. Wareham, Eleftheria Zeggini, John P. A. Ioannidis

American Journal of Epidemiology   ·   14 Jul 2009   ·   doi:10.1093/aje/kwp145

PubMed

Complex Traits T2D Collaborative

Common body mass index-associated variants confer risk of extreme obesity

Chris Cotsapas, Elizabeth K. Speliotes, Ida J. Hatoum, Danielle M. Greenawalt, Radu Dobrin, ..., Benjamin M. Neale, Eric E. Schadt, Joel N. Hirschhorn, Lee M. Kaplan, Mark J. Daly

Human Molecular Genetics   ·   24 Jun 2009   ·   doi:10.1093/hmg/ddp292

PubMed

Complex Traits Consortia Collaborative

Genome-wide association study identifies eight loci associated with blood pressure

Christopher Newton-Cheh, Toby Johnson, Vesela Gateva, Martin D Tobin, Murielle Bochud, ..., Ruth JF Loos, Paul Elliott, Gonçalo R Abecasis, Mark Caulfield, Patricia B Munroe

Nature Genetics   ·   10 May 2009   ·   doi:10.1038/ng.361

PubMed

Complex Traits Consortia Collaborative

Linkage Disequilibrium Mapping of the Replicated Type 2 Diabetes Linkage Signal on Chromosome 1q

Inga Prokopenko, Eleftheria Zeggini, Robert L. Hanson, Braxton D. Mitchell, N. William Rayner, ..., Steven C. Elbein, Panos Deloukas, Clifton Bogardus, Alan R. Shuldiner, Mark I. McCarthy

Diabetes   ·   23 Apr 2009   ·   doi:10.2337/db09-0081

PubMed

Complex Traits T2D Collaborative

The T-381C SNP in BNP gene may be modestly associated with type 2 diabetes: an updated meta-analysis in 49 279 subjects

Hélène Choquet, Christine Cavalcanti-Proença, Cécile Lecoeur, Christian Dina, Stéphane Cauchi, ..., Valgerdur Steinthorsdottir, Kari Stefansson, Beverley Balkau, Philippe Froguel, David Meyre

Human Molecular Genetics   ·   18 Apr 2009   ·   doi:10.1093/hmg/ddp169

PubMed

Complex Traits T2D Collaborative

New susceptibility locus for coronary artery disease on chromosome 3q22.3

Jeanette Erdmann, Anika Großhennig, Peter S Braund, Inke R König, Christian Hengstenberg, ..., Panos Deloukas, John R Thompson, Andreas Ziegler, Nilesh J Samani, Heribert Schunkert

Nature Genetics   ·   08 Feb 2009   ·   doi:10.1038/ng.307

PubMed

Complex Traits CAD/CVD Collaborative

Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants

[no author info]

Nature Genetics   ·   08 Feb 2009   ·   doi:10.1038/ng.327

PubMed

Selected Work Complex Traits CAD/CVD Consortia

2008

Variants in MTNR1B influence fasting glucose levels

Inga Prokopenko, Claudia Langenberg, Jose C Florez, Richa Saxena, Nicole Soranzo, ..., Kari Stefansson, Mark I McCarthy, Nicholas J Wareham, James B Meigs, Gonçalo R Abecasis

Nature Genetics   ·   07 Dec 2008   ·   doi:10.1038/ng.290

PubMed

Complex Traits T2D Consortia Collaborative

Common variants at 30 loci contribute to polygenic dyslipidemia

Sekar Kathiresan, Cristen J Willer, Gina M Peloso, Serkalem Demissie, Kiran Musunuru, ..., Jose M Ordovas, Michael Boehnke, Gonçalo R Abecasis, Karen L Mohlke, L Adrienne Cupples

Nature Genetics   ·   07 Dec 2008   ·   doi:10.1038/ng.291

PubMed

Complex Traits Pleiotropy Consortia Collaborative

Common Missense Variant in the Glucokinase Regulatory Protein Gene Is Associated With Increased Plasma Triglyceride and C-Reactive Protein but Lower Fasting Glucose Concentrations

Marju Orho-Melander, Olle Melander, Candace Guiducci, Pablo Perez-Martinez, Dolores Corella, ..., Peter Nilsson, Leif Groop, David Altshuler, Jose M. Ordovas, Sekar Kathiresan

Diabetes   ·   01 Nov 2008   ·   doi:10.2337/db08-0516

PubMed

Complex Traits T2D Consortia Collaborative

Practical aspects of imputation-driven meta-analysis of genome-wide association studies

P. I.W. de Bakker, M. A.R. Ferreira, X. Jia, B. M. Neale, S. Raychaudhuri, B. F. Voight

Human Molecular Genetics   ·   15 Oct 2008   ·   doi:10.1093/hmg/ddn288

PubMed

Selected Work Complex Traits Statistics Opinion/Review/Book Chapter

Common variants near MC4R are associated with fat mass, weight and risk of obesity

Ruth J F Loos, Cecilia M Lindgren, Shengxu Li, Eleanor Wheeler, Jing Hua Zhao, ..., Vincent Mooser, Panos Deloukas, Mark I McCarthy, Nicholas J Wareham, Inês Barroso

Nature Genetics   ·   04 May 2008   ·   doi:10.1038/ng.140

PubMed

Complex Traits Collaborative

Identification of ten loci associated with height highlights new biological pathways in human growth

Guillaume Lettre, Anne U Jackson, Christian Gieger, Fredrick R Schumacher, Sonja I Berndt, ..., Richard B Hayes, Gonçalo R Abecasis, H-Erich Wichmann, Karen L Mohlke, Joel N Hirschhorn

Nature Genetics   ·   06 Apr 2008   ·   doi:10.1038/ng.125

PubMed

Complex Traits Collaborative

Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes

Eleftheria Zeggini, Laura J Scott, Richa Saxena, Benjamin F Voight, Jonathan L Marchini, ..., Francis S Collins, Leif Groop, Mark I McCarthy, Michael Boehnke, David Altshuler

Nature Genetics   ·   30 Mar 2008   ·   doi:10.1038/ng.120

PubMed

Selected Work Complex Traits T2D Consortia

Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans

Sekar Kathiresan, Olle Melander, Candace Guiducci, Aarti Surti, Noël P Burtt, ..., Veikko Salomaa, Leena Peltonen, Leif Groop, David M Altshuler, Marju Orho-Melander

Nature Genetics   ·   13 Jan 2008   ·   doi:10.1038/ng.75

PubMed

Complex Traits Pleiotropy Collaborative

2007

A common variant of HMGA2 is associated with adult and childhood height in the general population

Michael N Weedon, Guillaume Lettre, Rachel M Freathy, Cecilia M Lindgren, Benjamin F Voight, ..., Leif C Groop, Andrew T Hattersley, Mark I McCarthy, Joel N Hirschhorn, Timothy M Frayling

Nature Genetics   ·   02 Sep 2007   ·   doi:10.1038/ng2121

PubMed

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Complex Traits Pleiotropy Collaborative

Genome-Wide Association Analysis Identifies Loci for Type 2 Diabetes and Triglyceride Levels

Richa Saxena, Benjamin F. Voight, Valeriya Lyssenko, Noël P. Burtt, Paul I. W. de Bakker, ..., Qicheng Ma, Hemang Parikh, Delwood Richardson, Darrell Ricke, Shaun Purcell

Science   ·   01 Jun 2007   ·   doi:10.1126/science.1142358

PubMed

PDF

News

Selected Work Complex Traits T2D Consortia

2006

Convergent adaptation of human lactase persistence in Africa and Europe

Sarah A Tishkoff, Floyd A Reed, Alessia Ranciaro, Benjamin F Voight, Courtney C Babbitt, ..., Jilur Ghori, Suzannah Bumpstead, Jonathan K Pritchard, Gregory A Wray, Panos Deloukas

Nature Genetics   ·   10 Dec 2006   ·   doi:10.1038/ng1946

PubMed

PDF

News

Selected Work Pop Gen Selection Collaborative

Coverage and Characteristics of the Affymetrix GeneChip Human Mapping 100K SNP Set

Dan L Nicolae, Xiaoquan Wen, Benjamin F Voight, Nancy J Cox

PLoS Genetics   ·   05 May 2006   ·   doi:10.1371/journal.pgen.0020067

PubMed

PDF

Complex Traits

A Map of Recent Positive Selection in the Human Genome

Benjamin F Voight, Sridhar Kudaravalli, Xiaoquan Wen, Jonathan K Pritchard

PLoS Biology   ·   07 Mar 2006   ·   doi:10.1371/journal.pbio.0040072

PubMed

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GitHub

News

Selected Work Pop Gen Selection Statistics Methods Development Software

2005

Interrogating multiple aspects of variation in a full resequencing data set to infer human population size changes

Benjamin F. Voight, Alison M. Adams, Linda A. Frisse, Yudong Qian, Richard R. Hudson, Anna Di Rienzo

Proceedings of the National Academy of Sciences   ·   13 Dec 2005   ·   doi:10.1073/pnas.0507325102

PubMed

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Selected Work Pop Gen Statistics Methods Development

Confounding from Cryptic Relatedness in Case-Control Association Studies

Benjamin F Voight, Jonathan K Pritchard

PLoS Genetics   ·   02 Sep 2005   ·   doi:10.1371/journal.pgen.0010032

PubMed

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Selected Work Complex Traits Pop Gen Statistics