Voight Lab

Publications

We have created extensive scholarship around method development and analysis of genetic data in humans, the central focus of my lab.

My roots began in population genetics, aiming to understand how the genome reveals details of our evolutionary history. Today, we are very are active in the development of methods in population genomics, which include characterization of mutation rates and studies of natural selection in human populations.

We are actively interested in the genetic dissection of complex traits. The statistical pipelines that we have developed and applied over my career have resulting in discovery of thousands of loci for complex traits, focused on type 2 diabetes, cardiovascular disease, and liver disease. This also include mapping of genetic variation associated with molecular phenotypes (eQTLs, sQTLs, caQTLs, etc.) using bulk tissue, cell model, and even single-cell resources in tissues relevant to these endpoints (e.g., pancreas).

We also have an active interest in the application of Mendelian randomization (MR) to evaluate causal hypotheses between biomarkers and cardiometabolic endpoints, including most famously rejecting a protective role for HDL Cholesterol in heart disease.

I need to prettify the publication listing below (Work in progress)!

But feel free to follow the Pubmed and Google Scholar links below to see a full list of my publications.

More on PubMed
More on Google Scholar

All

Selected Works:

Selected Work Collaborative Preprint

Discipline/Approach Areas:

Complex Traits Mendelian Randomization QTL Mapping Pop Gen Selection Mutation Rate Spiders

Phenotypic Areas:

T2D T1D CAD/CVD MASLD Pleiotropy

Consortia Work:

Consortia T2D-GGI MVP

Approaches/Software:

Statistics AI/ML Automation Methods Development Software

2024

Evaluation of Plasma Biomarkers for Causal Association With Peripheral Artery Disease
Evaluation of Plasma Biomarkers for Causal Association With Peripheral Artery Disease
Pranav Sharma, Derek Klarin, Benjamin F. Voight, Philip S. Tsao, Michael G. Levin, Scott M. Damrauer
Arteriosclerosis, Thrombosis, and Vascular Biology   ·   28 Mar 2024   ·   doi:10.1161/ATVBAHA.124.320674
Major Depressive Disorder Impacts Peripheral Artery Disease Risk Through Intermediary Risk Factors
Major Depressive Disorder Impacts Peripheral Artery Disease Risk Through Intermediary Risk Factors
Gabrielle Shakt, Noah L. Tsao, Michael G. Levin, Venexia Walker, Rachel L. Kember, Derek Klarin, Phil Tsao, Benjamin F. Voight, Salvatore T. Scali, Scott M. Damrauer
Journal of the American Heart Association   ·   20 Feb 2024   ·   doi:10.1161/JAHA.123.030233
PubMed
Complex Traits Mendelian Randomization CAD/CVD Pleiotropy Collaborative
Genetic drivers of heterogeneity in type 2 diabetes pathophysiology
Genetic drivers of heterogeneity in type 2 diabetes pathophysiology
Ken Suzuki, Konstantinos Hatzikotoulas, Lorraine Southam, Henry J. Taylor, Xianyong Yin, ..., Jerome I. Rotter, Marijana Vujkovic, Benjamin F. Voight, Andrew P. Morris, Eleftheria Zeggini
Nature   ·   19 Feb 2024   ·   doi:10.1038/s41586-024-07019-6
PubMed
Selected Work Complex Traits T2D CAD/CVD Pleiotropy Consortia T2D-GGI MVP
Trans-ancestral genome-wide association study of longitudinal pubertal height growth and shared heritability with adult health outcomes
Trans-ancestral genome-wide association study of longitudinal pubertal height growth and shared heritability with adult health outcomes
Jonathan P. Bradfield, Rachel L. Kember, Anna Ulrich, Zhanna Balkiyarova, Akram Alyass, ..., Inga Prokopenko, Benjamin F. Voight, Babette S. Zemel, Struan F. A. Grant, Diana L. Cousminer
Genome Biology   ·   16 Jan 2024   ·   doi:10.1186/s13059-023-03136-z
PubMed
Selected Work Complex Traits Consortia Collaborative

2023

Projecting genetic associations through gene expression patterns highlights disease etiology and drug mechanisms
Projecting genetic associations through gene expression patterns highlights disease etiology and drug mechanisms
Milton Pividori, Sumei Lu, Binglan Li, Chun Su, Matthew E. Johnson, ..., Benjamin F. Voight, Carsten Skarke, Marylyn D. Ritchie, Struan F. A. Grant, Casey S. Greene
Nature Communications   ·   09 Sep 2023   ·   doi:10.1038/s41467-023-41057-4
PubMed
Complex Traits Pleiotropy AI/ML Methods Development Software
Deciphering the genetic architecture of atrial fibrillation offers insights into disease prediction, pathophysiology and downstream sequelae
Deciphering the genetic architecture of atrial fibrillation offers insights into disease prediction, pathophysiology and downstream sequelae
Shuai Yuan, Yuying Li, Lijuan Wang, Fengzhe Xu, Jie Chen, ..., Agneta Åkesson, Karl Michaëlsson, Xue Li, Xia Shen, Susanna C. Larsson
Cold Spring Harbor Laboratory   ·   25 Jul 2023   ·   doi:10.1101/2023.07.20.23292938
PubMed
Preprint Complex Traits CAD/CVD Collaborative
Regularized sequence-context mutational trees capture variation in mutation rates across the human genome
Regularized sequence-context mutational trees capture variation in mutation rates across the human genome
Christopher J. Adams, Mitchell Conery, Benjamin J. Auerbach, Shane T. Jensen, Iain Mathieson, Benjamin F. Voight
PLOS Genetics   ·   07 Jul 2023   ·   doi:10.1371/journal.pgen.1010807
PubMed
GitHub
Selected Work Pop Gen Mutation Rate Statistics Methods Development Software
Evaluating the Contribution of Cell Type–Specific Alternative Splicing to Variation in Lipid Levels
Evaluating the Contribution of Cell Type–Specific Alternative Splicing to Variation in Lipid Levels
Katerina A.B. Gawronski, William P. Bone, YoSon Park, Evanthia E. Pashos, Brandon M. Wenz, ..., Wenli Yang, Daniel J. Rader, Kiran Musunuru, Benjamin F. Voight, Christopher D. Brown
Circulation: Genomic and Precision Medicine   ·   01 Jun 2023   ·   doi:10.1161/CIRCGEN.120.003249
PubMed
Selected Work Complex Traits QTL Mapping
Evaluating the Contribution of Cell Type–Specific Alternative Splicing to Variation in Lipid Levels
Evaluating the Contribution of Cell Type–Specific Alternative Splicing to Variation in Lipid Levels
Katerina A.B. Gawronski, William P. Bone, YoSon Park, Evanthia E. Pashos, Brandon M. Wenz, ..., Wenli Yang, Daniel J. Rader, Kiran Musunuru, Benjamin F. Voight, Christopher D. Brown
Circulation: Genomic and Precision Medicine   ·   01 Jun 2023   ·   doi:10.1161/circgen.120.003249
G6PC2 controls glucagon secretion by defining the setpoint for glucose in pancreatic α-cells
G6PC2 controls glucagon secretion by defining the setpoint for glucose in pancreatic α-cells
Varun Bahl, Eric Waite, Reut Rifkind, Zenab Hamdan, Catherine Lee May, ..., Mark Tigue, Nicholas Manuto, Benjamin Glaser, Dana Avrahami, Klaus H. Kaestner
Cold Spring Harbor Laboratory   ·   24 May 2023   ·   doi:10.1101/2023.05.23.541901
Preprint T2D T1D Consortia Collaborative
Genetically proxied glucose-lowering drug target perturbation and risk of cancer: a Mendelian randomisation analysis
Genetically proxied glucose-lowering drug target perturbation and risk of cancer: a Mendelian randomisation analysis
James Yarmolinsky, Emmanouil Bouras, Andrei Constantinescu, Kimberley Burrows, Caroline J. Bull, ..., Peter Kraft, William J. Blot, Elio Riboli, Dipender Gill, Kostas K. Tsilidis
Diabetologia   ·   12 May 2023   ·   doi:10.1007/s00125-023-05925-4
PubMed
Complex Traits Mendelian Randomization Pleiotropy Collaborative
Evaluation of the Performance of the RECODe Equation with the Addition of Polygenic Risk Scores for Adverse Cardiovascular Outcomes in Individuals with Type II Diabetes
Evaluation of the Performance of the RECODe Equation with the Addition of Polygenic Risk Scores for Adverse Cardiovascular Outcomes in Individuals with Type II Diabetes
Noah L. Tsao, Renae Judy, Michael G. Levin, Gabrielle Shakt, Benjamin F. Voight, Jinbo Chen, Scott M. Damrauer
Cold Spring Harbor Laboratory   ·   05 May 2023   ·   doi:10.1101/2023.05.03.23289457
PubMed
Preprint Complex Traits T2D CAD/CVD Pleiotropy Collaborative
Evaluation of plasma biomarkers for causal association with peripheral artery disease
Evaluation of plasma biomarkers for causal association with peripheral artery disease
Pranav Sharma, Michael G. Levin, Derek Klarin, Benjamin F. Voight, Philip S. Tsao, Scott M. Damrauer
Cold Spring Harbor Laboratory   ·   05 May 2023   ·   doi:10.1101/2023.05.05.23289560
Preprint Complex Traits Mendelian Randomization CAD/CVD Pleiotropy Collaborative
Mendelian Randomization Analysis Reveals a Complex Genetic Interplay among Atopic Dermatitis, Asthma, and Gastroesophageal Reflux Disease
Mendelian Randomization Analysis Reveals a Complex Genetic Interplay among Atopic Dermatitis, Asthma, and Gastroesophageal Reflux Disease
Kwangmi Ahn, Raymond B. Penn, Satish Rattan, Reynold A. Panettieri, Benjamin F. Voight, Steven S. An
American Journal of Respiratory and Critical Care Medicine   ·   15 Jan 2023   ·   doi:10.1164/rccm.202205-0951OC
PubMed
Complex Traits Mendelian Randomization Collaborative
Mendelian Randomization Analysis Reveals a Complex Genetic Interplay among Atopic Dermatitis, Asthma, and Gastroesophageal Reflux Disease
Mendelian Randomization Analysis Reveals a Complex Genetic Interplay among Atopic Dermatitis, Asthma, and Gastroesophageal Reflux Disease
Kwangmi Ahn, Raymond B. Penn, Satish Rattan, Reynold A. Panettieri, Benjamin F. Voight, Steven S. An
American Journal of Respiratory and Critical Care Medicine   ·   15 Jan 2023   ·   doi:10.1164/rccm.202205-0951oc

2022

Genomics and phenomics of body mass index reveals a complex disease network
Genomics and phenomics of body mass index reveals a complex disease network
Jie Huang, Jennifer E. Huffman, Yunfeng Huang, Ítalo Do Valle, Themistocles L. Assimes, ..., Kelly Cho, Kyong-Mi Chang, Peter W. F. Wilson, Yan V. Sun, Christopher J. O’Donnell
Nature Communications   ·   29 Dec 2022   ·   doi:10.1038/s41467-022-35553-2
PubMed
Complex Traits Mendelian Randomization Pleiotropy Consortia Collaborative MVP
Genome-wide association and multi-trait analyses characterize the common genetic architecture of heart failure
Genome-wide association and multi-trait analyses characterize the common genetic architecture of heart failure
Michael G. Levin, Noah L. Tsao, Pankhuri Singhal, Chang Liu, Ha My T. Vy, ..., Christopher M. Haggerty, Jacob Joseph, Yan V. Sun, Benjamin F. Voight, Scott M. Damrauer
Nature Communications   ·   14 Nov 2022   ·   doi:10.1038/s41467-022-34216-6
PubMed
Selected Work Complex Traits Mendelian Randomization CAD/CVD Pleiotropy
Regularized sequence-context mutational trees capture variation in mutation rates across the human genome
Regularized sequence-context mutational trees capture variation in mutation rates across the human genome
Christopher J. Adams, Mitchell Conery, Benjamin J. Auerbach, Shane T. Jensen, Iain Mathieson, Benjamin F. Voight
Cold Spring Harbor Laboratory   ·   17 Oct 2022   ·   doi:10.1101/2022.10.14.512160
GitHub
Preprint Pop Gen Mutation Rate Statistics Methods Development Software
Estimating the effect size of a hidden causal factor between SNPs and a continuous trait: a mediation model approach
Estimating the effect size of a hidden causal factor between SNPs and a continuous trait: a mediation model approach
Zhuoran Ding, Marylyn D. Ritchie, Benjamin F. Voight, Wei-Ting Hwang
BMC Bioinformatics   ·   13 Oct 2022   ·   doi:10.1186/s12859-022-04977-4
PubMed
PDF
GitHub
Selected Work Complex Traits Statistics Methods Development Software
Identifying rare variants inconsistent with identity‐by‐descent in population‐scale whole‐genome sequencing data
Identifying rare variants inconsistent with identity‐by‐descent in population‐scale whole‐genome sequencing data
Kelsey E. Johnson, Christopher J. Adams, Benjamin F. Voight
Methods in Ecology and Evolution   ·   11 Oct 2022   ·   doi:10.1111/2041-210X.13991
PDF
GitHub
Selected Work Pop Gen Mutation Rate Statistics Methods Development Software
Polygenic Risk Scores in Alzheimer’s Disease Genetics: Methodology, Applications, Inclusion, and Diversity
Polygenic Risk Scores in Alzheimer’s Disease Genetics: Methodology, Applications, Inclusion, and Diversity
Kaylyn Clark, Yuk Yee Leung, Wan-Ping Lee, Benjamin Voight, Li-San Wang
Journal of Alzheimer's Disease   ·   30 Aug 2022   ·   doi:10.3233/JAD-220025
PubMed
Complex Traits Opinion/Review/Book Chapter
Large-scale genome-wide association study of coronary artery disease in genetically diverse populations
Large-scale genome-wide association study of coronary artery disease in genetically diverse populations
Catherine Tcheandjieu, Xiang Zhu, Austin T. Hilliard, Shoa L. Clarke, Valerio Napolioni, ..., Hua Tang, Yan V. Sun, Philip S. Tsao, Christopher J. O’Donnell, Themistocles L. Assimes
Nature Medicine   ·   01 Aug 2022   ·   doi:10.1038/s41591-022-01891-3
PubMed
Complex Traits CAD/CVD Consortia Collaborative MVP
ColocQuiaL: a QTL-GWAS colocalization pipeline
ColocQuiaL: a QTL-GWAS colocalization pipeline
Brian Y Chen, William P Bone, Kim Lorenz, Michael Levin, Marylyn D Ritchie, Benjamin F Voight
Bioinformatics   ·   27 Jul 2022   ·   doi:10.1093/bioinformatics/btac512
PubMed
GitHub
Selected Work Complex Traits Automation Methods Development Software
Estimating the effect size of a hidden causal factor between SNPs and a continuous trait: a mediation model approach
Estimating the effect size of a hidden causal factor between SNPs and a continuous trait: a mediation model approach
Zhuoran Ding, Marylyn D. Ritchie, Benjamin F. Voight, Wei-Ting Hwang
Cold Spring Harbor Laboratory   ·   29 Jun 2022   ·   doi:10.1101/2022.06.28.497617
GitHub
Preprint Complex Traits Statistics Methods Development Software
Epigenomic and transcriptomic analyses define core cell types, genes and targetable mechanisms for kidney disease
Epigenomic and transcriptomic analyses define core cell types, genes and targetable mechanisms for kidney disease
Hongbo Liu, Tomohito Doke, Dong Guo, Xin Sheng, Ziyuan Ma, ..., Hongzhe Li, Christopher D. Brown, Marylyn D. Ritchie, Yan Shu, Katalin Susztak
Nature Genetics   ·   16 Jun 2022   ·   doi:10.1038/s41588-022-01097-w
PubMed
Complex Traits QTL Mapping Collaborative
TSABL: Trait Specific Annotation Based Locus predictor
TSABL: Trait Specific Annotation Based Locus predictor
Kim Lorenz, Christopher S. Thom, Sanjana Adurty, Benjamin F. Voight
BMC Genomics   ·   15 Jun 2022   ·   doi:10.1186/s12864-022-08654-x
PubMed
Selected Work Complex Traits Pleiotropy AI/ML Methods Development Software
Characterization of the genome and silk-gland transcriptomes of Darwin’s bark spider (Caerostris darwini)
Characterization of the genome and silk-gland transcriptomes of Darwin’s bark spider (Caerostris darwini)
Paul L. Babb, Matjaž Gregorič, Nicholas F. Lahens, David N. Nicholson, Cheryl Y. Hayashi, Linden Higgins, Matjaž Kuntner, Ingi Agnarsson, Benjamin F. Voight
PLOS ONE   ·   06 Jun 2022   ·   doi:10.1371/journal.pone.0268660
PubMed
PDF
Selected Work Pop Gen Spiders
A multi-population phenome-wide association study of genetically-predicted height in the Million Veteran Program
A multi-population phenome-wide association study of genetically-predicted height in the Million Veteran Program
Sridharan Raghavan, Jie Huang, Catherine Tcheandjieu, Jennifer E. Huffman, Elizabeth Litkowski, ..., Kyong-Mi Chang, Kelly Cho, Christopher J. O’Donnell, Yan V. Sun, Themistocles L. Assimes
PLOS Genetics   ·   02 Jun 2022   ·   doi:10.1371/journal.pgen.1010193
PubMed
Complex Traits Mendelian Randomization Pleiotropy Collaborative MVP
A multiancestry genome-wide association study of unexplained chronic ALT elevation as a proxy for nonalcoholic fatty liver disease with histological and radiological validation
A multiancestry genome-wide association study of unexplained chronic ALT elevation as a proxy for nonalcoholic fatty liver disease with histological and radiological validation
Marijana Vujkovic, Shweta Ramdas, Kim M. Lorenz, Xiuqing Guo, Rebecca Darlay, ..., Jerome I. Rotter, Julie A. Lynch, Daniel J. Rader, Benjamin F. Voight, Kyong-Mi Chang
Nature Genetics   ·   01 Jun 2022   ·   doi:10.1038/s41588-022-01078-z
PubMed
Selected Work Complex Traits MASLD Consortia MVP
Multi‐phenotype analyses of hemostatic traits with cardiovascular events reveal novel genetic associations
Multi‐phenotype analyses of hemostatic traits with cardiovascular events reveal novel genetic associations
Gerard Temprano‐Sagrera, Colleen M. Sitlani, William P. Bone, Miguel Martin‐Bornez, Benjamin F. Voight, ..., Hugh S Markus, Joanna MM Howson, Yoichiro Kamatani, Stephanie Debette, Martin Dichgans
Journal of Thrombosis and Haemostasis   ·   01 Jun 2022   ·   doi:10.1111/jth.15698
PubMed
PDF
Complex Traits CAD/CVD Pleiotropy Collaborative
A Phenome-Wide Association Study of genes associated with COVID-19 severity reveals shared genetics with complex diseases in the Million Veteran Program
A Phenome-Wide Association Study of genes associated with COVID-19 severity reveals shared genetics with complex diseases in the Million Veteran Program
Anurag Verma, Noah L. Tsao, Lauren O. Thomann, Yuk-Lam Ho, Sudha K. Iyengar, ..., Philip S. Tsao, J. Michael Gaziano, Christopher O’Donnell, Scott M. Damrauer, Katherine P. Liao
PLOS Genetics   ·   28 Apr 2022   ·   doi:10.1371/journal.pgen.1010113
PubMed
PDF
Complex Traits Collaborative MVP
Body mass index and adipose distribution have opposing genetic impacts on human blood traits
Body mass index and adipose distribution have opposing genetic impacts on human blood traits
Christopher S Thom, Madison B Wilken, Stella T Chou, Benjamin F Voight
eLife   ·   15 Feb 2022   ·   doi:10.7554/eLife.75317
PubMed
Selected Work Complex Traits Mendelian Randomization Pleiotropy
Body mass index and adipose distribution have opposing genetic impacts on human blood traits
Body mass index and adipose distribution have opposing genetic impacts on human blood traits
Christopher S Thom, Madison B Wilken, Stella T Chou, Benjamin F Voight
eLife   ·   15 Feb 2022   ·   doi:10.7554/elife.75317
Separating the direct effects of traits on atherosclerotic cardiovascular disease from those mediated by type 2 diabetes
Separating the direct effects of traits on atherosclerotic cardiovascular disease from those mediated by type 2 diabetes
Venexia M. Walker, Marijana Vujkovic, Alice R. Carter, Neil M. Davies, Miriam S. Udler, Michael G. Levin, George Davey Smith, Benjamin F. Voight, Tom R. Gaunt, Scott M. Damrauer
Diabetologia   ·   07 Feb 2022   ·   doi:10.1007/s00125-022-05653-1
PubMed
PDF
Complex Traits Mendelian Randomization T2D CAD/CVD Pleiotropy Collaborative
Multi-Trait Genome-Wide Association Study of Atherosclerosis Detects Novel Pleiotropic Loci
Multi-Trait Genome-Wide Association Study of Atherosclerosis Detects Novel Pleiotropic Loci
Tiffany R. Bellomo, William P. Bone, Brian Y. Chen, Katerina A. B. Gawronski, David Zhang, ..., Philip S. Tsao, Daniel J. Rader, Marylyn D. Ritchie, Scott M. Damrauer, Benjamin F. Voight
Frontiers in Genetics   ·   02 Feb 2022   ·   doi:10.3389/fgene.2021.787545
PubMed
Selected Work Complex Traits CAD/CVD Pleiotropy

2021

Mendelian randomization analyses clarify the effects of height on cardiovascular diseases
Mendelian randomization analyses clarify the effects of height on cardiovascular diseases
Daniel Hui, Eric Sanford, Kimberly Lorenz, Scott M. Damrauer, Themistocles L. Assimes, Christopher S. Thom, Benjamin F. Voight
Cold Spring Harbor Laboratory   ·   17 Dec 2021   ·   doi:10.1101/2021.12.16.21267869
Preprint Complex Traits Mendelian Randomization CAD/CVD Pleiotropy
Cis-regulatory architecture of human ESC-derived hypothalamic neuron differentiation aids in variant-to-gene mapping of relevant complex traits
Cis-regulatory architecture of human ESC-derived hypothalamic neuron differentiation aids in variant-to-gene mapping of relevant complex traits
Matthew C. Pahl, Claudia A. Doege, Kenyaita M. Hodge, Sheridan H. Littleton, Michelle E. Leonard, ..., Andrew D. Wells, Benjamin F. Voight, Rudolph L. Leibel, Diana L. Cousminer, Struan F. A. Grant
Nature Communications   ·   19 Nov 2021   ·   doi:10.1038/s41467-021-27001-4
PubMed
Complex Traits Collaborative
ColocQuiaL: A QTL-GWAS colocalization pipeline
ColocQuiaL: A QTL-GWAS colocalization pipeline
Brian Y. Chen, William P. Bone, Kimberly Lorenz, Michael Levin, Marylyn D. Ritchie, Benjamin F. Voight
Cold Spring Harbor Laboratory   ·   09 Nov 2021   ·   doi:10.1101/2021.11.05.21265991
GitHub
Preprint Complex Traits Automation Methods Development Software
Obesity and adiposity have opposing genetic impacts on human blood traits
Obesity and adiposity have opposing genetic impacts on human blood traits
Christopher S Thom, Madison B Wilken, Stella T Chou, Benjamin F Voight
Cold Spring Harbor Laboratory   ·   07 Nov 2021   ·   doi:10.1101/2021.11.05.467482
Preprint Complex Traits Mendelian Randomization Pleiotropy
A Missense Variant in the IL-6 Receptor and Protection From Peripheral Artery Disease
A Missense Variant in the IL-6 Receptor and Protection From Peripheral Artery Disease
Michael G. Levin, Derek Klarin, Marios K. Georgakis, Julie Lynch, Katherine P. Liao, ..., Christopher J. O’Donnell, Kyong-Mi Chang, Themistocles L. Assimes, Philip S. Tsao, Scott M. Damrauer
Circulation Research   ·   29 Oct 2021   ·   doi:10.1161/CIRCRESAHA.121.319589
PubMed
Complex Traits Mendelian Randomization CAD/CVD Collaborative
TSABL: Trait Specific Annotation Based Locus Predictor
TSABL: Trait Specific Annotation Based Locus Predictor
Kimberly Lorenz, Christopher S. Thom, Sanjana Adurty, Benjamin F. Voight
Cold Spring Harbor Laboratory   ·   29 Sep 2021   ·   doi:10.1101/2021.09.27.21264198
Preprint Complex Traits Pleiotropy AI/ML Methods Development Software
Evaluation of height as a disease risk factor through a phenome-wide association study of genetically-predicted height
Evaluation of height as a disease risk factor through a phenome-wide association study of genetically-predicted height
Sridharan Raghavan, Jie Huang, Catherine Tcheandjieu, Jennifer E. Huffman, Elizabeth Litkowski, ..., Kyong-Mi Chang, Kelly Cho, Christopher J. O’Donnell, Yan V. Sun, Themistocles L. Assimes
Cold Spring Harbor Laboratory   ·   30 Aug 2021   ·   doi:10.1101/2021.08.29.21262793
Preprint Complex Traits Mendelian Randomization Pleiotropy
A single genetic locus controls both expression of DPEP1/CHMP1A and kidney disease development via ferroptosis
A single genetic locus controls both expression of DPEP1/CHMP1A and kidney disease development via ferroptosis
Yuting Guan, Xiujie Liang, Ziyuan Ma, Hailong Hu, Hongbo Liu, Zhen Miao, Andreas Linkermann, Jacklyn N. Hellwege, Benjamin F. Voight, Katalin Susztak
Nature Communications   ·   23 Aug 2021   ·   doi:10.1038/s41467-021-25377-x
PubMed
Complex Traits Collaborative
Mapping the genetic architecture of human traits to cell types in the kidney identifies mechanisms of disease and potential treatments
Mapping the genetic architecture of human traits to cell types in the kidney identifies mechanisms of disease and potential treatments
Xin Sheng, Yuting Guan, Ziyuan Ma, Junnan Wu, Hongbo Liu, ..., Mingyao Li, Benjamin F. Voight, Thomas M. Coffman, Christopher D. Brown, Katalin Susztak
Nature Genetics   ·   12 Aug 2021   ·   doi:10.1038/s41588-021-00909-9
PubMed
Complex Traits QTL Mapping Collaborative
Separating the direct effects of risk factors for atherosclerotic cardiovascular disease from those mediated by type 2 diabetes
Separating the direct effects of risk factors for atherosclerotic cardiovascular disease from those mediated by type 2 diabetes
Venexia M Walker, Marijana Vujkovic, Alice R Carter, Neil M Davies, Miriam S Udler, Michael G Levin, George Davey Smith, Benjamin F Voight, Tom R Gaunt, Scott M Damrauer
Cold Spring Harbor Laboratory   ·   07 Aug 2021   ·   doi:10.1101/2021.08.05.21261658
Preprint Mendelian Randomization T2D CAD/CVD Pleiotropy
Multi-ancestry Multivariate Genome-Wide Analysis Highlights the Role of Common Genetic Variation in Cardiac Structure, Function, and Heart Failure-related Traits
Multi-ancestry Multivariate Genome-Wide Analysis Highlights the Role of Common Genetic Variation in Cardiac Structure, Function, and Heart Failure-related Traits
Michael G. Levin, Noah L. Tsao, Tiffany R. Bellomo, William P. Bone, Krishna G. Aragam, ..., Sharlene M. Day, Patrick T. Ellinor, Kenneth B. Margulies, Benjamin F. Voight, Scott M. Damrauer
Cold Spring Harbor Laboratory   ·   05 Aug 2021   ·   doi:10.1101/2021.08.03.21261508
Preprint Complex Traits CAD/CVD Pleiotropy
Prioritizing the Role of Major Lipoproteins and Subfractions as Risk Factors for Peripheral Artery Disease
Prioritizing the Role of Major Lipoproteins and Subfractions as Risk Factors for Peripheral Artery Disease
Michael G. Levin, Verena Zuber, Venexia M. Walker, Derek Klarin, Julie Lynch, ..., Philip S. Tsao, Benjamin F. Voight, Dipender Gill, Stephen Burgess, Scott M. Damrauer
Circulation   ·   03 Aug 2021   ·   doi:10.1161/CIRCULATIONAHA.121.053797
PubMed
Complex Traits Mendelian Randomization CAD/CVD Pleiotropy
Projecting genetic associations through gene expression patterns highlights disease etiology and drug mechanisms
Projecting genetic associations through gene expression patterns highlights disease etiology and drug mechanisms
Milton Pividori, Sumei Lu, Binglan Li, Chun Su, Matthew E. Johnson, ..., Benjamin F. Voight, Carsten Skarke, Marylyn D. Ritchie, Struan F.A. Grant, Casey S. Greene
Cold Spring Harbor Laboratory   ·   06 Jul 2021   ·   doi:10.1101/2021.07.05.450786
Preprint
Genetic Evidence for Repurposing of GLP1R (Glucagon‐Like Peptide‐1 Receptor) Agonists to Prevent Heart Failure
Genetic Evidence for Repurposing of GLP1R (Glucagon‐Like Peptide‐1 Receptor) Agonists to Prevent Heart Failure
Iyas Daghlas, Ville Karhunen, Devleena Ray, Verena Zuber, Stephen Burgess, ..., Emma H. Baker, Scott M. Damrauer, Joanna M. M. Howson, Marijana Vujkovic, Dipender Gill
Journal of the American Heart Association   ·   06 Jul 2021   ·   doi:10.1161/JAHA.120.020331
PubMed
Complex Traits Mendelian Randomization CAD/CVD Collaborative
A unified framework identifies new links between plasma lipids and diseases from electronic medical records across large-scale cohorts
A unified framework identifies new links between plasma lipids and diseases from electronic medical records across large-scale cohorts
Yogasudha Veturi, Anastasia Lucas, Yuki Bradford, Daniel Hui, Scott Dudek, ..., Thomas J. Hoffmann, Neil Risch, Benjamin F. Voight, Daniel J. Rader, Marylyn D. Ritchie
Nature Genetics   ·   17 Jun 2021   ·   doi:10.1038/s41588-021-00879-y
PubMed
Complex Traits Mendelian Randomization Pleiotropy Collaborative
Association Between Genetic Variation in Blood Pressure and Increased Lifetime Risk of Peripheral Artery Disease
Association Between Genetic Variation in Blood Pressure and Increased Lifetime Risk of Peripheral Artery Disease
Michael G. Levin, Derek Klarin, Venexia M. Walker, Dipender Gill, Julie Lynch, ..., Neil M. Davies, Philip S. Tsao, Kyong-Mi Chang, Benjamin F. Voight, Scott M. Damrauer
Arteriosclerosis, Thrombosis, and Vascular Biology   ·   01 Jun 2021   ·   doi:10.1161/ATVBAHA.120.315482
PubMed
Selected Work Complex Traits Mendelian Randomization CAD/CVD Pleiotropy
Multi-trait GWAS of atherosclerosis detects novel pleiotropic loci
Multi-trait GWAS of atherosclerosis detects novel pleiotropic loci
Tiffany R. Bellomo, William P. Bone, Brian Y. Chen, Katerina A. B. Gawronski, David Zhang, ..., Phil S. Tsao, Daniel J. Rader, Marylyn D. Ritchie, Benjamin F. Voight, Scott M. Damrauer
Cold Spring Harbor Laboratory   ·   23 May 2021   ·   doi:10.1101/2021.05.21.21257493
Preprint Complex Traits CAD/CVD Pleiotropy
A Phenome-Wide Association Study of genes associated with COVID-19 severity reveals shared genetics with complex diseases in the Million Veteran Program
A Phenome-Wide Association Study of genes associated with COVID-19 severity reveals shared genetics with complex diseases in the Million Veteran Program
Anurag Verma, Noah Tsao, Lauren Thomann, Yuk-Lam Ho, Sudha Iyengar, ..., Philip S. Tsao, J. Michael Gaziano, Christopher O’Donnell, Scott Damrauer, Katherine Liao
Cold Spring Harbor Laboratory   ·   23 May 2021   ·   doi:10.1101/2021.05.18.21257396
Preprint Complex Traits Consortia Collaborative MVP
Genetic analysis in European ancestry individuals identifies 517 loci associated with liver enzymes
Genetic analysis in European ancestry individuals identifies 517 loci associated with liver enzymes
Raha Pazoki, Marijana Vujkovic, Joshua Elliott, Evangelos Evangelou, Dipender Gill, ..., Shahpoor Shayan, Stacey B. Whitbourne, Jim L. Breeling, J. P. Casas Romero, Rachel B. Ramoni
Nature Communications   ·   10 May 2021   ·   doi:10.1038/s41467-021-22338-2
PubMed
Selected Work Complex Traits MASLD Consortia MVP
Multi-trait association studies discover pleiotropic loci between Alzheimer’s disease and cardiometabolic traits
Multi-trait association studies discover pleiotropic loci between Alzheimer’s disease and cardiometabolic traits
William P. Bone, Katherine M. Siewert, Anupama Jha, Derek Klarin, Scott M. Damrauer, Kyong-Mi Chang, Philip S. Tsao, Themistocles L. Assimes, Marylyn D. Ritchie, Benjamin F. Voight
Alzheimer's Research & Therapy   ·   04 Feb 2021   ·   doi:10.1186/s13195-021-00773-z
PubMed
Selected Work Complex Traits Pleiotropy
Genetics of Smoking and Risk of Atherosclerotic Cardiovascular Diseases
Genetics of Smoking and Risk of Atherosclerotic Cardiovascular Diseases
Michael G. Levin, Derek Klarin, Themistocles L. Assimes, Matthew S. Freiberg, Erik Ingelsson, ..., Daniel J. Rader, Philip S. Tsao, Kyong-Mi Chang, Benjamin F. Voight, Scott M. Damrauer
JAMA Network Open   ·   19 Jan 2021   ·   doi:10.1001/jamanetworkopen.2020.34461
PubMed
Selected Work Complex Traits Mendelian Randomization CAD/CVD Pleiotropy Consortia MVP
Prioritizing the Role of Major Lipoproteins and Subfractions as Risk Factors for Peripheral Artery Disease
Prioritizing the Role of Major Lipoproteins and Subfractions as Risk Factors for Peripheral Artery Disease
Michael G. Levin, Verena Zuber, Venexia M. Walker, Derek Klarin, Julie Lynch, ..., Philip S. Tsao, Benjamin F. Voight, Dipender Gill, Stephen Burgess, Scott M. Damrauer
Cold Spring Harbor Laboratory   ·   15 Jan 2021   ·   doi:10.1101/2021.01.11.21249148
Preprint Complex Traits Mendelian Randomization CAD/CVD Pleiotropy
Genome-wide association study implicates novel loci and reveals candidate effector genes for longitudinal pediatric bone accrual
Genome-wide association study implicates novel loci and reveals candidate effector genes for longitudinal pediatric bone accrual
Diana L. Cousminer, Yadav Wagley, James A. Pippin, Ahmed Elhakeem, Gregory P. Way, ..., Benjamin F. Voight, Andrew D. Wells, Babette S. Zemel, Kurt D. Hankenson, Struan F. A. Grant
Genome Biology   ·   04 Jan 2021   ·   doi:10.1186/s13059-020-02207-9
PubMed
Complex Traits Collaborative
A trans-ancestry genome-wide association study of unexplained chronic ALT elevation as a proxy for nonalcoholic fatty liver disease with histological and radiological validation
A trans-ancestry genome-wide association study of unexplained chronic ALT elevation as a proxy for nonalcoholic fatty liver disease with histological and radiological validation
Marijana Vujkovic, Shweta Ramdas, Kimberly M. Lorenz, Xiuqing Guo, Rebecca Darlay, ..., Jerome I. Rotter, Julie A. Lynch, Daniel J. Rader, Benjamin F. Voight, Kyong-Mi Chang
Cold Spring Harbor Laboratory   ·   02 Jan 2021   ·   doi:10.1101/2020.12.26.20248491
Preprint Complex Traits MASLD Consortia MVP

2020

Golden orb-weaving spider (<i>Trichonephila clavipes</i>) silk genes with sex-biased expression and atypical architectures
Golden orb-weaving spider (Trichonephila clavipes) silk genes with sex-biased expression and atypical architectures
Sandra M Correa-Garhwal, Paul L Babb, Benjamin F Voight, Cheryl Y Hayashi
G3 Genes|Genomes|Genetics   ·   22 Dec 2020   ·   doi:10.1093/G3JOURNAL/JKAA039
PubMed
Selected Work Pop Gen Spiders
Genetic Predisposition to Coronary Artery Disease in Type 2 Diabetes Mellitus
Genetic Predisposition to Coronary Artery Disease in Type 2 Diabetes Mellitus
Natalie R. van Zuydam, Claes Ladenvall, Benjamin F. Voight, Rona J. Strawbridge, Juan Fernandez-Tajes, ..., Li-ming Gan, Everson Nogoceke, Piero Tortoli, Bernd Jablonka, Mary-Julia Brosnan
Circulation: Genomic and Precision Medicine   ·   01 Dec 2020   ·   doi:10.1161/CIRCGEN.119.002769
PubMed
Complex Traits T2D CAD/CVD Pleiotropy Collaborative
Mapping the genetic architecture of human traits to cell types in the kidney identifies mechanisms of disease and potential treatments
Mapping the genetic architecture of human traits to cell types in the kidney identifies mechanisms of disease and potential treatments
Xin Sheng, Ziyuan Ma, Junnan Wu, Hongbo Liu, Chengxiang Qiu, ..., Mingyao Li, Benjamin Voight, Thomas Coffman, Christopher D. Brown, Katalin Susztak
Cold Spring Harbor Laboratory   ·   10 Nov 2020   ·   doi:10.1101/2020.11.09.375592
Preprint Complex Traits QTL Mapping Collaborative
Genetics of height and risk of atrial fibrillation: A Mendelian randomization study
Genetics of height and risk of atrial fibrillation: A Mendelian randomization study
Michael G. Levin, Renae Judy, Dipender Gill, Marijana Vujkovic, Shefali S. Verma, ..., Matthew C. Hyman, Saman Nazarian, Daniel J. Rader, Benjamin F. Voight, Scott M. Damrauer
PLOS Medicine   ·   08 Oct 2020   ·   doi:10.1371/journal.pmed.1003288
PubMed
Selected Work Complex Traits Mendelian Randomization CAD/CVD
The relationship between circulating lipids and breast cancer risk: A Mendelian randomization study
The relationship between circulating lipids and breast cancer risk: A Mendelian randomization study
Kelsey E. Johnson, Katherine M. Siewert, Derek Klarin, Scott M. Damrauer, Kyong-Mi Chang, Philip S. Tsao, Themistocles L. Assimes, Kara N. Maxwell, Benjamin F. Voight
PLOS Medicine   ·   11 Sep 2020   ·   doi:10.1371/journal.pmed.1003302
PubMed
Complex Traits Mendelian Randomization CAD/CVD
Multi-trait association studies discover pleiotropic loci between Alzheimer’s disease and cardiometabolic traits
Multi-trait association studies discover pleiotropic loci between Alzheimer’s disease and cardiometabolic traits
William P. Bone, Katherine M. Siewert, Anupama Jha, Derek Klarin, Scott M. Damrauer, Kyong-Mi Chang, Philip S. Tsao, Themistocles L. Assimes, Marylyn D. Ritchie, Benjamin F. Voight
Cold Spring Harbor Laboratory   ·   01 Sep 2020   ·   doi:10.1101/2020.08.26.20179366
Preprint Complex Traits Pleiotropy
Validating a non-invasive, ALT-based non-alcoholic fatty liver phenotype in the million veteran program
Validating a non-invasive, ALT-based non-alcoholic fatty liver phenotype in the million veteran program
Marina Serper, Marijana Vujkovic, David E. Kaplan, Rotonya M. Carr, Kyung Min Lee, ..., Scott M. Damrauer, Julie A. Lynch, Danish Saleheen, Benjamin F. Voight, Kyong-Mi Chang
PLOS ONE   ·   25 Aug 2020   ·   doi:10.1371/journal.pone.0237430
PubMed
Selected Work Complex Traits MASLD Consortia MVP
Genetic Variation in Blood Pressure and Lifetime Risk of Peripheral Artery Disease: A Mendelian Randomization Study
Genetic Variation in Blood Pressure and Lifetime Risk of Peripheral Artery Disease: A Mendelian Randomization Study
Michael G. Levin, Derek Klarin, Venexia M. Walker, Dipender Gill, Julie Lynch, ..., Neil M. Davies, Philip S. Tsao, Kyong-Mi Chang, Benjamin F. Voight, Scott M. Damrauer
Cold Spring Harbor Laboratory   ·   25 Aug 2020   ·   doi:10.1101/2020.08.23.20180240
Preprint Complex Traits Mendelian Randomization CAD/CVD Pleiotropy Consortia MVP
Genetic determinants of increased body mass index mediate the effect of smoking on increased risk for type 2 diabetes but not coronary artery disease
Genetic determinants of increased body mass index mediate the effect of smoking on increased risk for type 2 diabetes but not coronary artery disease
Christopher S Thom, Zhuoran Ding, Michael G Levin, Scott M Damrauer, Kyung Min Lee, ..., Themistocles L Assimes, Yan V Sun, Christopher J O’Donnell, Marijana Vujkovic, Benjamin F Voight
Human Molecular Genetics   ·   24 Aug 2020   ·   doi:10.1093/hmg/ddaa193
PubMed
Selected Work Complex Traits Mendelian Randomization Pleiotropy
Type 1 diabetes in Africa: an immunogenetic study in the Amhara of North-West Ethiopia
Type 1 diabetes in Africa: an immunogenetic study in the Amhara of North-West Ethiopia
Shitaye A. Balcha, Abayneh G. Demisse, Rajashree Mishra, Tanwi Vartak, Diana L. Cousminer, ..., Alistair J. K. Williams, Struan F. A. Grant, R. David Leslie, David I. W. Phillips, Elisabeth R. Trimble
Diabetologia   ·   23 Jul 2020   ·   doi:10.1007/s00125-020-05229-x
PubMed
Complex Traits CAD/CVD Collaborative
Cis-regulatory architecture of human ESC-derived hypothalamic neuron differentiation aids in variant-to-gene mapping of relevant complex traits
Cis-regulatory architecture of human ESC-derived hypothalamic neuron differentiation aids in variant-to-gene mapping of relevant complex traits
Matthew C. Pahl, Claudia A. Doege, Kenyaita M. Hodge, Sheridan H. Littleton, Michelle E. Leonard, ..., Andrew D. Wells, Benjamin F. Voight, Rudolph L. Leibel, Diana L. Cousminer, Struan F.A. Grant
Cold Spring Harbor Laboratory   ·   06 Jul 2020   ·   doi:10.1101/2020.07.06.146951
Preprint Complex Traits Collaborative
Genetic colocalization atlas points to common regulatory sites and genes for hematopoietic traits and hematopoietic contributions to disease phenotypes
Genetic colocalization atlas points to common regulatory sites and genes for hematopoietic traits and hematopoietic contributions to disease phenotypes
Christopher S. Thom, Benjamin F. Voight
BMC Medical Genomics   ·   29 Jun 2020   ·   doi:10.1186/s12920-020-00742-9
PubMed
Selected Work Complex Traits Pleiotropy
Discovery of 318 new risk loci for type 2 diabetes and related vascular outcomes among 1.4 million participants in a multi-ancestry meta-analysis
Discovery of 318 new risk loci for type 2 diabetes and related vascular outcomes among 1.4 million participants in a multi-ancestry meta-analysis
Marijana Vujkovic, Jacob M. Keaton, Julie A. Lynch, Donald R. Miller, Jin Zhou, ..., J. Michael Gaziano, Sumitra Muralidhar, Kyong-Mi Chang, Benjamin F. Voight, Danish Saleheen
Nature Genetics   ·   15 Jun 2020   ·   doi:10.1038/s41588-020-0637-y
PubMed
Selected Work Complex Traits T2D Consortia MVP
Genetically Determined Birthweight Associates With Atrial Fibrillation
Genetically Determined Birthweight Associates With Atrial Fibrillation
Rachel L. Kember, Michael G. Levin, Diana L. Cousminer, Noah Tsao, Renae Judy, ..., Shana E. McCormack, Struan F.A. Grant, Daniel J. Rader, Benjamin F. Voight, Scott M. Damrauer
Circulation: Genomic and Precision Medicine   ·   01 Jun 2020   ·   doi:10.1161/CIRCGEN.119.002553
PubMed
Selected Work Complex Traits Mendelian Randomization CAD/CVD Pleiotropy Consortia MVP
Identifying non-identical-by-descent rare variants in population-scale whole genome sequencing data
Identifying non-identical-by-descent rare variants in population-scale whole genome sequencing data
Kelsey E. Johnson, Benjamin F. Voight
Cold Spring Harbor Laboratory   ·   28 May 2020   ·   doi:10.1101/2020.05.26.117358
GitHub
Preprint Pop Gen Mutation Rate AI/ML Methods Development Software
Tropomyosin 1 genetically constrains in vitro hematopoiesis
Tropomyosin 1 genetically constrains in vitro hematopoiesis
Christopher Stephen Thom, Chintan D Jobaliya, Kimberly Lorenz, Jean Ann Maguire, Alyssa Gagne, Paul Gadue, Deborah L French, Benjamin Franklin Voight
BMC Biology   ·   14 May 2020   ·   doi:10.1186/s12915-020-00783-7
PubMed
Selected Work Complex Traits Pleiotropy AI/ML
Cross-trait analyses with migraine reveal widespread pleiotropy and suggest a vascular component to migraine headache
Cross-trait analyses with migraine reveal widespread pleiotropy and suggest a vascular component to migraine headache
Katherine M Siewert, Derek Klarin, Scott M Damrauer, Kyong-Mi Chang, Philip S Tsao, ..., Benjamin M Neale, Jes Olesen, Daniel I Chasman, Dale R Nyholt, Aarno Palotie
International Journal of Epidemiology   ·   19 Apr 2020   ·   doi:10.1093/IJE/DYAA050
PubMed
Complex Traits Mendelian Randomization CAD/CVD Pleiotropy
A missense variant in Mitochondrial Amidoxime Reducing Component 1 gene and protection against liver disease
A missense variant in Mitochondrial Amidoxime Reducing Component 1 gene and protection against liver disease
Connor A. Emdin, Mary E. Haas, Amit V. Khera, Krishna Aragam, Mark Chaffin, ..., Craig Hanis, Mark Daly, Joshua Denny, Stacey Gabriel, Sekar Kathiresan
PLOS Genetics   ·   13 Apr 2020   ·   doi:10.1371/journal.pgen.1008629
PubMed
Complex Traits MASLD Consortia Collaborative MVP
Genetics of Smoking and Risk of Atherosclerotic Cardiovascular Diseases: A Mendelian Randomization Study
Genetics of Smoking and Risk of Atherosclerotic Cardiovascular Diseases: A Mendelian Randomization Study
Michael G. Levin, Derek Klarin, Themistocles L. Assimes, Matthew S. Freiberg, Erik Ingelsson, ..., Daniel J. Rader, Philip S. Tsao, Kyong-Mi Chang, Benjamin F. Voight, Scott M. Damrauer
Cold Spring Harbor Laboratory   ·   08 Apr 2020   ·   doi:10.1101/2020.04.07.20053447
Preprint Complex Traits Mendelian Randomization CAD/CVD Consortia MVP
Genome-wide association study implicates novel loci and reveals candidate effector genes for longitudinal pediatric bone accrual through variant-to-gene mapping
Genome-wide association study implicates novel loci and reveals candidate effector genes for longitudinal pediatric bone accrual through variant-to-gene mapping
Diana L. Cousminer, Yadav Wagley, James A. Pippin, Ahmed Elhakeem, Gregory P. Way, ..., Benjamin F. Voight, Andrew D. Wells, Babette S. Zemel, Kurt Hankenson, Struan F. A. Grant
Cold Spring Harbor Laboratory   ·   20 Feb 2020   ·   doi:10.1101/2020.02.17.20024133
Preprint Complex Traits Collaborative
Genetically determined body mass index mediates the effect of smoking on type 2 diabetes risk, but not coronary artery disease risk
Genetically determined body mass index mediates the effect of smoking on type 2 diabetes risk, but not coronary artery disease risk
Christopher S Thom, Zhuoran Ding, Michael G Levin, Scott M Damrauer, Benjamin F Voight
Cold Spring Harbor Laboratory   ·   03 Feb 2020   ·   doi:10.1101/2020.01.30.20019737
Preprint Complex Traits Mendelian Randomization Pleiotropy
BetaScan2: Standardized Statistics to Detect Balancing Selection Utilizing Substitution Data
BetaScan2: Standardized Statistics to Detect Balancing Selection Utilizing Substitution Data
Katherine M Siewert, Benjamin F Voight
Genome Biology and Evolution   ·   01 Feb 2020   ·   doi:10.1093/gbe/evaa013
PubMed
GitHub
Selected Work Pop Gen Selection Statistics Methods Development Software

2019

Genetics of Height and Risk of Atrial Fibrillation: A Mendelian Randomization Study
Genetics of Height and Risk of Atrial Fibrillation: A Mendelian Randomization Study
Michael G. Levin, Renae Judy, Dipender Gill, Marijana Vujkovic, Matthew C. Hyman, Saman Nazarian, Daniel J. Rader, Benjamin F. Voight, Scott M. Damrauer
Cold Spring Harbor Laboratory   ·   30 Dec 2019   ·   doi:10.1101/2019.12.23.19015743
Preprint Complex Traits Mendelian Randomization CAD/CVD
Genetic Discrimination Between LADA and Childhood-Onset Type 1 Diabetes Within the MHC
Genetic Discrimination Between LADA and Childhood-Onset Type 1 Diabetes Within the MHC
Rajashree Mishra, Mikael Åkerlund, Diana L. Cousminer, Emma Ahlqvist, Jonathan P. Bradfield, ..., Stanley Schwartz, Bernhard O. Boehm, Leif Groop, Richard David Leslie, Struan F.A. Grant
Diabetes Care   ·   16 Dec 2019   ·   doi:10.2337/dc19-0986
PubMed
Complex Traits T1D Collaborative
Discovery of 318 novel loci for type-2 diabetes and related micro- and macrovascular outcomes among 1.4 million participants in a multi-ethnic meta-analysis
Discovery of 318 novel loci for type-2 diabetes and related micro- and macrovascular outcomes among 1.4 million participants in a multi-ethnic meta-analysis
Marijana Vujkovic, Jacob M. Keaton, Julie A. Lynch, Donald R. Miller, Jin Zhou, ..., Christopher J. O’Donnell, Philip S. Tsao, Kyong-Mi Chang, Benjamin F. Voight, Danish Saleheen
Cold Spring Harbor Laboratory   ·   25 Nov 2019   ·   doi:10.1101/19012690
Preprint Complex Traits T2D Consortia MVP
Natural human genetic variation determines basal and inducible expression of <i>PM20D1</i> , an obesity-associated gene
Natural human genetic variation determines basal and inducible expression of PM20D1 , an obesity-associated gene
Kiara K. Benson, Wenxiang Hu, Angela H. Weller, Alexis H. Bennett, Eric R. Chen, ..., William P. Bone, Lin Wang, Joshua D. Rabinowitz, Benjamin F. Voight, Raymond E. Soccio
Proceedings of the National Academy of Sciences   ·   28 Oct 2019   ·   doi:10.1073/pnas.1913199116
PubMed
Complex Traits Collaborative
Assessing a causal relationship between circulating lipids and breast cancer risk: Mendelian randomization study
Assessing a causal relationship between circulating lipids and breast cancer risk: Mendelian randomization study
Kelsey E. Johnson, Katherine M. Siewert, Derek Klarin, Scott M. Damrauer, Kyong-Mi Chang, Philip S. Tsao, Themistocles L. Assimes, Kara N. Maxwell, Benjamin F. Voight
Cold Spring Harbor Laboratory   ·   06 Oct 2019   ·   doi:10.1101/794594
Preprint Complex Traits Mendelian Randomization Pleiotropy
Genetic colocalization atlas points to common regulatory sites and genes for hematopoietic traits and hematopoietic contributions to disease phenotypes
Genetic colocalization atlas points to common regulatory sites and genes for hematopoietic traits and hematopoietic contributions to disease phenotypes
CS Thom, BF Voight
Cold Spring Harbor Laboratory   ·   30 Sep 2019   ·   doi:10.1101/787333
Preprint Complex Traits Pleiotropy
Projected Prevalence of Actionable Pharmacogenetic Variants and Level A Drugs Prescribed Among US Veterans Health Administration Pharmacy Users
Projected Prevalence of Actionable Pharmacogenetic Variants and Level A Drugs Prescribed Among US Veterans Health Administration Pharmacy Users
Catherine Chanfreau-Coffinier, Leland E. Hull, Julie A. Lynch, Scott L. DuVall, Scott M. Damrauer, ..., Benjamin F. Voight, Michael E. Matheny, David W. Oslin, Michael S. Icardi, Sony Tuteja
JAMA Network Open   ·   07 Jun 2019   ·   doi:10.1001/jamanetworkopen.2019.5345
PubMed
Complex Traits MASLD Consortia MVP
Evaluating the contribution of cell-type specific alternative splicing to variation in lipid levels
Evaluating the contribution of cell-type specific alternative splicing to variation in lipid levels
K.A.B. Gawronski, W. Bone, Y. Park, E. Pashos, X. Wang, W. Yang, D. Rader, K. Musunuru, B. Voight, C. Brown
Cold Spring Harbor Laboratory   ·   04 Jun 2019   ·   doi:10.1101/659326
Preprint Complex Traits QTL Mapping
<i>Tropomyosin 1</i> genetically constrains <i>in vitro</i> hematopoiesis
Tropomyosin 1 genetically constrains in vitro hematopoiesis
CS Thom, CD Jobaliya, K Lorenz, JA Maguire, A Gagne, P Gadue, DL French, BF Voight
Cold Spring Harbor Laboratory   ·   08 May 2019   ·   doi:10.1101/631895
Preprint Complex Traits Pleiotropy AI/ML
Postmenopausal osteoporotic fracture-associated COLIA1 variant impacts bone accretion in girls
Postmenopausal osteoporotic fracture-associated COLIA1 variant impacts bone accretion in girls
Diana L. Cousminer, Shana E. McCormack, Jonathan A. Mitchell, Alessandra Chesi, Joseph M. Kindler, ..., John A. Shepherd, Sharon E. Oberfield, Vicente Gilsanz, Babette S. Zemel, Struan F.A. Grant
Bone   ·   01 Apr 2019   ·   doi:10.1016/j.bone.2019.01.026
PubMed
Complex Traits Collaborative
Signals of Variation in Human Mutation Rate at Multiple Levels of Sequence Context
Signals of Variation in Human Mutation Rate at Multiple Levels of Sequence Context
Rachael C Aikens, Kelsey E Johnson, Benjamin F Voight
Molecular Biology and Evolution   ·   07 Feb 2019   ·   doi:10.1093/molbev/msz023
PubMed
Selected Work Pop Gen Mutation Rate
Keen on the tenure track job, are you? Know these things, you should
Keen on the tenure track job, are you? Know these things, you should
Benjamin F. Voight
Genome Biology   ·   07 Jan 2019   ·   doi:10.1186/s13059-018-1617-8
PubMed
Selected Work Opinion/Review/Book Chapter

2018

BetaScan2: Standardized statistics to detect balancing selection utilizing substitution data:
BetaScan2: Standardized statistics to detect balancing selection utilizing substitution data:
Katherine M Siewert, Benjamin F Voight
Cold Spring Harbor Laboratory   ·   17 Dec 2018   ·   doi:10.1101/497255
GitHub
Preprint Pop Gen Selection Statistics Methods Development Software
Bivariate Genome-Wide Association Scan Identifies 6 Novel Loci Associated With Lipid Levels and Coronary Artery Disease
Bivariate Genome-Wide Association Scan Identifies 6 Novel Loci Associated With Lipid Levels and Coronary Artery Disease
Katherine M. Siewert, Benjamin F. Voight
Circulation: Genomic and Precision Medicine   ·   01 Dec 2018   ·   doi:10.1161/CIRCGEN.118.002239
PubMed
Selected Work Complex Traits CAD/CVD Pleiotropy
First Genome-Wide Association Study of Latent Autoimmune Diabetes in Adults Reveals Novel Insights Linking Immune and Metabolic Diabetes
First Genome-Wide Association Study of Latent Autoimmune Diabetes in Adults Reveals Novel Insights Linking Immune and Metabolic Diabetes
Diana L. Cousminer, Emma Ahlqvist, Rajashree Mishra, Mette K. Andersen, Alessandra Chesi, ..., Joan M. Lappe, John A. Shepherd, Sharon E. Oberfield, Vicente Gilsanz, Babette S. Zemel
Diabetes Care   ·   15 Oct 2018   ·   doi:10.2337/dc18-1032
PubMed
Complex Traits T1D Pleiotropy Collaborative
Signals of variation in human mutation rate at multiple levels of sequence context
Signals of variation in human mutation rate at multiple levels of sequence context
Rachael C. Aikens, Kelsey E. Johnson, Benjamin F. Voight
Cold Spring Harbor Laboratory   ·   04 Aug 2018   ·   doi:10.1101/385096
Preprint Pop Gen Mutation Rate
Multiplexed Targeted Resequencing Identifies Coding and Regulatory Variation Underlying Phenotypic Extremes of High-Density Lipoprotein Cholesterol in Humans
Multiplexed Targeted Resequencing Identifies Coding and Regulatory Variation Underlying Phenotypic Extremes of High-Density Lipoprotein Cholesterol in Humans
Sumeet A. Khetarpal, Paul L. Babb, Wei Zhao, William F. Hancock-Cerutti, Christopher D. Brown, Daniel J. Rader, Benjamin F. Voight
Circulation: Genomic and Precision Medicine   ·   01 Jul 2018   ·   doi:10.1161/CIRCGEN.117.002070
PubMed
Selected Work Complex Traits CAD/CVD
Dissecting an adiposity locus with an arsenal of genomics
Dissecting an adiposity locus with an arsenal of genomics
Kim Lorenz, Benjamin F. Voight
Genome Biology   ·   07 Jun 2018   ·   doi:10.1186/s13059-018-1460-y
PubMed
Opinion/Review/Book Chapter
Bivariate GWAS scan identifies six novel loci associated with lipid levels and coronary artery disease
Bivariate GWAS scan identifies six novel loci associated with lipid levels and coronary artery disease
Katherine M. Siewert, Benjamin F. Voight
Cold Spring Harbor Laboratory   ·   11 May 2018   ·   doi:10.1101/319848
Preprint Complex Traits CAD/CVD Pleiotropy
Patterns of shared signatures of recent positive selection across human populations
Patterns of shared signatures of recent positive selection across human populations
Kelsey Elizabeth Johnson, Benjamin F. Voight
Nature Ecology & Evolution   ·   19 Feb 2018   ·   doi:10.1038/s41559-018-0478-6
PubMed
Selected Work Pop Gen Selection Statistics Methods Development Software

2017

Sequence data and association statistics from 12,940 type 2 diabetes cases and controls
Sequence data and association statistics from 12,940 type 2 diabetes cases and controls
Jason Flannick, Christian Fuchsberger, Anubha Mahajan, Tanya M. Teslovich, Vineeta Agarwala, ..., David Altshuler, Noël P. Burtt, Jose C. Florez, Michael Boehnke, Mark I. McCarthy
Scientific Data   ·   19 Dec 2017   ·   doi:10.1038/sdata.2017.179
PubMed
Complex Traits T2D
Multiplexed targeted resequencing identifies coding and regulatory variation underlying phenotypic extremes of HDL-cholesterol in humans
Multiplexed targeted resequencing identifies coding and regulatory variation underlying phenotypic extremes of HDL-cholesterol in humans
Sumeet A. Khetarpal, Paul L. Babb, Wei Zhao, William F. Hancock-Cerutti, Christopher D. Brown, Daniel J. Rader, Benjamin F. Voight
Cold Spring Harbor Laboratory   ·   18 Dec 2017   ·   doi:10.1101/235887
Preprint Complex Traits CAD/CVD
Genetically Determined Later Puberty Impacts Lowered Bone Mineral Density in Childhood and Adulthood
Genetically Determined Later Puberty Impacts Lowered Bone Mineral Density in Childhood and Adulthood
Diana L Cousminer, Jonathan A Mitchell, Alessandra Chesi, Sani M Roy, Heidi J Kalkwarf, ..., Andrea Kelly, Shana E McCormack, Benjamin F Voight, Babette S Zemel, Struan FA Grant
Journal of Bone and Mineral Research   ·   25 Oct 2017   ·   doi:10.1002/jbmr.3320
PubMed
Complex Traits Collaborative
Identification of new susceptibility loci for type 2 diabetes and shared etiological pathways with coronary heart disease
Identification of new susceptibility loci for type 2 diabetes and shared etiological pathways with coronary heart disease
Wei Zhao, Asif Rasheed, Emmi Tikkanen, Jung-Jin Lee, Adam S Butterworth, ..., Veikko Salomaa, Daniel J Rader, John Danesh, Benjamin F Voight, Danish Saleheen
Nature Genetics   ·   04 Sep 2017   ·   doi:10.1038/ng.3943
PubMed
Selected Work Complex Traits T2D CAD/CVD Pleiotropy
Detecting Long-Term Balancing Selection Using Allele Frequency Correlation
Detecting Long-Term Balancing Selection Using Allele Frequency Correlation
Katherine M. Siewert, Benjamin F. Voight
Molecular Biology and Evolution   ·   21 Jul 2017   ·   doi:10.1093/molbev/msx209
PubMed
GitHub
Selected Work Pop Gen Selection Statistics Methods Development Software
An Expanded Genome-Wide Association Study of Type 2 Diabetes in Europeans
An Expanded Genome-Wide Association Study of Type 2 Diabetes in Europeans
Robert A. Scott, Laura J. Scott, Reedik Mägi, Letizia Marullo, Kyle J. Gaulton, ..., Josée Dupuis, Andrew P. Morris, Michael Boehnke, Mark I. McCarthy, Inga Prokopenko
Diabetes   ·   31 May 2017   ·   doi:10.2337/db16-1253
PubMed
Complex Traits T2D Collaborative
Gene Set Enrichment Analyses: lessons learned from the heart failure phenotype
Gene Set Enrichment Analyses: lessons learned from the heart failure phenotype
Vinicius Tragante, Johannes M. I. H. Gho, Janine F. Felix, Ramachandran S. Vasan, Nicholas L. Smith, Benjamin F. Voight, Colin Palmer, Pim van der Harst, Jason H. Moore, Folkert W. Asselbergs
BioData Mining   ·   26 May 2017   ·   doi:10.1186/s13040-017-0137-5
PubMed
Complex Traits CAD/CVD Collaborative
The Nephila clavipes genome highlights the diversity of spider silk genes and their complex expression
The Nephila clavipes genome highlights the diversity of spider silk genes and their complex expression
Paul L Babb, Nicholas F Lahens, Sandra M Correa-Garhwal, David N Nicholson, Eun Ji Kim, ..., Matjaž Kuntner, Linden Higgins, Cheryl Y Hayashi, Ingi Agnarsson, Benjamin F Voight
Nature Genetics   ·   01 May 2017   ·   doi:10.1038/ng.3852
PubMed
Selected Work Pop Gen Spiders
Relative contribution of type 1 and type 2 diabetes loci to the genetic etiology of adult-onset, non-insulin-requiring autoimmune diabetes
Relative contribution of type 1 and type 2 diabetes loci to the genetic etiology of adult-onset, non-insulin-requiring autoimmune diabetes
Rajashree Mishra, Alessandra Chesi, Diana L. Cousminer, Mohammad I. Hawa, Jonathan P. Bradfield, ..., Benjamin F. Voight, Stanley Schwartz, Bernhard O. Boehm, Richard David Leslie, Struan F. A. Grant
BMC Medicine   ·   25 Apr 2017   ·   doi:10.1186/s12916-017-0846-0
PubMed
Complex Traits T2D T1D Pleiotropy Collaborative
Large-Scale trans -eQTLs Affect Hundreds of Transcripts and Mediate Patterns of Transcriptional Co-regulation
Large-Scale trans -eQTLs Affect Hundreds of Transcripts and Mediate Patterns of Transcriptional Co-regulation
Boel Brynedal, JinMyung Choi, Towfique Raj, Robert Bjornson, Barbara E. Stranger, Benjamin M. Neale, Benjamin F. Voight, Chris Cotsapas
The American Journal of Human Genetics   ·   01 Apr 2017   ·   doi:10.1016/j.ajhg.2017.02.004
PubMed
Complex Traits QTL Mapping Pleiotropy Collaborative
Detecting Long-term Balancing Selection using Allele Frequency Correlation
Detecting Long-term Balancing Selection using Allele Frequency Correlation
Katherine M. Siewert, Benjamin F. Voight
Cold Spring Harbor Laboratory   ·   01 Mar 2017   ·   doi:10.1101/112870
GitHub
Preprint Pop Gen Selection Statistics Methods Development Software
Patterns of shared signatures of recent positive selection across human populations
Patterns of shared signatures of recent positive selection across human populations
Kelsey Elizabeth Johnson, Benjamin F. Voight
Cold Spring Harbor Laboratory   ·   17 Feb 2017   ·   doi:10.1101/109371
Preprint Pop Gen Selection Statistics Methods Development Software
De novo mutational profile in RB1 clarified using a mutation rate modeling algorithm
De novo mutational profile in RB1 clarified using a mutation rate modeling algorithm
Varun Aggarwala, Arupa Ganguly, Benjamin F. Voight
BMC Genomics   ·   14 Feb 2017   ·   doi:10.1186/s12864-017-3522-z
PubMed
Selected Work Complex Traits Mutation Rate Statistics Methods Development

2016

Serum calcium and risk of migraine: a Mendelian randomization study
Serum calcium and risk of migraine: a Mendelian randomization study
Peter Yin, Verneri Anttila, Katherine M. Siewert, Aarno Palotie, George Davey Smith, Benjamin F. Voight
Human Molecular Genetics   ·   26 Dec 2016   ·   doi:10.1093/hmg/ddw416
PubMed
Selected Work Complex Traits Mendelian Randomization Pleiotropy
Type 2 Diabetes Genes Gleaned by Making a β-Cell Screen Routine
Type 2 Diabetes Genes Gleaned by Making a β-Cell Screen Routine
Benjamin F. Voight, Struan F.A. Grant
Diabetes   ·   12 Nov 2016   ·   doi:10.2337/dbi16-0054
PubMed
Opinion/Review/Book Chapter
Assessing the general population frequency of rare coding variants in the EXT1 and EXT2 genes previously implicated in hereditary multiple exostoses
Assessing the general population frequency of rare coding variants in the EXT1 and EXT2 genes previously implicated in hereditary multiple exostoses
Diana L. Cousminer, Alexandre Arkader, Benjamin F. Voight, Maurizio Pacifici, Struan F.A. Grant
Bone   ·   01 Nov 2016   ·   doi:10.1016/j.bone.2016.09.005
PubMed
Complex Traits
Systolic Blood Pressure and Risk of Type 2 Diabetes: A Mendelian Randomization Study
Systolic Blood Pressure and Risk of Type 2 Diabetes: A Mendelian Randomization Study
Rachael C. Aikens, Wei Zhao, Danish Saleheen, Muredach P. Reilly, Stephen E. Epstein, Emmi Tikkanen, Veikko Salomaa, Benjamin F. Voight
Diabetes   ·   04 Oct 2016   ·   doi:10.2337/db16-0868
PubMed
Selected Work Complex Traits Mendelian Randomization T2D Pleiotropy
The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals
The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals
Georg B Ehret, Teresa Ferreira, Daniel I Chasman, Anne U Jackson, Ellen M Schmidt, ..., Aravinda Chakravarti, Panos Deloukas, Andrew P Morris, Christopher Newton-Cheh, Patricia B Munroe
Nature Genetics   ·   12 Sep 2016   ·   doi:10.1038/ng.3667
PubMed
Complex Traits Collaborative
Disentangling the Causal Association of Plasma Lipid Traits and Type 2 Diabetes Using Human Genetics
Disentangling the Causal Association of Plasma Lipid Traits and Type 2 Diabetes Using Human Genetics
Danish Saleheen, Daniel J. Rader, Benjamin F. Voight
JAMA Cardiology   ·   01 Sep 2016   ·   doi:10.1001/jamacardio.2016.2298
PubMed
Opinion/Review/Book Chapter
The genetic architecture of type 2 diabetes
The genetic architecture of type 2 diabetes
Christian Fuchsberger, Jason Flannick, Tanya M. Teslovich, Anubha Mahajan, Vineeta Agarwala, ..., Andrew P. Morris, Hyun Min Kang, Michael Boehnke, David Altshuler, Mark I. McCarthy
Nature   ·   11 Jul 2016   ·   doi:10.1038/nature18642
PubMed
Complex Traits T2D Consortia Collaborative
Pathway and network-based strategies to translate genetic discoveries into effective therapies
Pathway and network-based strategies to translate genetic discoveries into effective therapies
Casey S. Greene, Benjamin F. Voight
Human Molecular Genetics   ·   23 Jun 2016   ·   doi:10.1093/hmg/ddw160
PubMed
Opinion/Review/Book Chapter
Large-scale <i>trans</i>-eQTLs affect hundreds of transcripts and mediate patterns of transcriptional co-regulation Short: <i>trans</i>-eQTLs reveal patterns of transcriptional co-regulation
Large-scale trans-eQTLs affect hundreds of transcripts and mediate patterns of transcriptional co-regulation Short: trans-eQTLs reveal patterns of transcriptional co-regulation
Boel Brynedal, JinMyung Choi, Towfique Raj, Robert Bjornson, Barbara E Stranger, Benjamin M Neale, Benjamin F Voight, Chris Cotsapas
Cold Spring Harbor Laboratory   ·   31 May 2016   ·   doi:10.1101/056283
Preprint Complex Traits QTL Mapping Pleiotropy Collaborative
An expanded sequence context model broadly explains variability in polymorphism levels across the human genome
An expanded sequence context model broadly explains variability in polymorphism levels across the human genome
Varun Aggarwala, Benjamin F Voight
Nature Genetics   ·   15 Feb 2016   ·   doi:10.1038/ng.3511
PubMed
Selected Work Pop Gen Mutation Rate Statistics Methods Development
Human genetics shines a light on ischaemic stroke
Human genetics shines a light on ischaemic stroke
Benjamin F Voight, Daniel J Rader
The Lancet Neurology   ·   01 Feb 2016   ·   doi:10.1016/S1474-4422(15)00400-7
PubMed
Opinion/Review/Book Chapter
Causal Assessment of Serum Urate Levels in Cardiometabolic Diseases Through a Mendelian Randomization Study
Causal Assessment of Serum Urate Levels in Cardiometabolic Diseases Through a Mendelian Randomization Study
Tanya Keenan, Wei Zhao, Asif Rasheed, Weang K. Ho, Rainer Malik, ..., Muredach P. Reilly, John Danesh, Daniel J. Rader, Benjamin F. Voight, Danish Saleheen
Journal of the American College of Cardiology   ·   01 Feb 2016   ·   doi:10.1016/j.jacc.2015.10.086
PubMed
Selected Work Complex Traits Mendelian Randomization T2D CAD/CVD Pleiotropy
Causal Inference in Medicine via Mendelian Randomization
Causal Inference in Medicine via Mendelian Randomization
Timothy M. Frayling, Benjamin F. Voight
The Genetics of Type 2 Diabetes and Related Traits   ·   01 Jan 2016   ·   doi:10.1007/978-3-319-01574-3_24
Selected Work Complex Traits Mendelian Randomization Opinion/Review/Book Chapter

2015

Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci
Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci
Kyle J Gaulton, Teresa Ferreira, Yeji Lee, Anne Raimondo, Reedik Mägi, ..., David Altshuler, Michael Boehnke, Tanya M Teslovich, Mark I McCarthy, Andrew P Morris
Nature Genetics   ·   09 Nov 2015   ·   doi:10.1038/ng.3437
PubMed
Complex Traits T2D
Genetic variants primarily associated with type 2 diabetes are related to coronary artery disease risk
Genetic variants primarily associated with type 2 diabetes are related to coronary artery disease risk
Henning Jansen, Christina Loley, Wolfgang Lieb, Michael J. Pencina, Christopher P. Nelson, ..., Inke R. König, Ramachandran S. Vasan, Jeanette Erdmann, Nilesh J. Samani, Heribert Schunkert
Atherosclerosis   ·   01 Aug 2015   ·   doi:10.1016/j.atherosclerosis.2015.05.033
PubMed
Complex Traits T2D CAD/CVD Collaborative
Genetic Variation Determines PPARγ Function and Anti-diabetic Drug Response In Vivo
Genetic Variation Determines PPARγ Function and Anti-diabetic Drug Response In Vivo
Raymond E. Soccio, Eric R. Chen, Satyajit R. Rajapurkar, Pegah Safabakhsh, Jill M. Marinis, ..., David J. Steger, Ying Wu, Mete Civelek, Benjamin F. Voight, Mitchell A. Lazar
Cell   ·   01 Jul 2015   ·   doi:10.1016/j.cell.2015.06.025
PubMed
Complex Traits T2D Collaborative

2014

MeRP: a high-throughput pipeline for Mendelian randomization analysis
MeRP: a high-throughput pipeline for Mendelian randomization analysis
Peter Yin, Benjamin F. Voight
Bioinformatics   ·   10 Nov 2014   ·   doi:10.1093/bioinformatics/btu742
PubMed
Complex Traits Mendelian Randomization Automation Methods Development Software
MR_predictor: a simulation engine for Mendelian Randomization studies
MR_predictor: a simulation engine for Mendelian Randomization studies
Benjamin F. Voight
Bioinformatics   ·   26 Aug 2014   ·   doi:10.1093/bioinformatics/btu564
PubMed
GitHub
Selected Work Complex Traits Mendelian Randomization Statistics Methods Development Software
Pleiotropic genes for metabolic syndrome and inflammation
Pleiotropic genes for metabolic syndrome and inflammation
Aldi T. Kraja, Daniel I. Chasman, Kari E. North, Alexander P. Reiner, Lisa R. Yanek, ..., Emelia J. Benjamin, Behrooz Z. Alizadeh, Inga Prokopenko, James B. Meigs, Ingrid B. Borecki
Molecular Genetics and Metabolism   ·   01 Aug 2014   ·   doi:10.1016/j.ymgme.2014.04.007
PubMed
Complex Traits Pleiotropy Consortia Collaborative
A Central Role for GRB10 in Regulation of Islet Function in Man
A Central Role for GRB10 in Regulation of Islet Function in Man
Inga Prokopenko, Wenny Poon, Reedik Mägi, Rashmi Prasad B, S. Albert Salehi, ..., Alan R. Shuldiner, Kristi D. Silver, Markku Laakso, Leif Groop, Valeriya Lyssenko
PLoS Genetics   ·   03 Apr 2014   ·   doi:10.1371/journal.pgen.1004235
PubMed
Complex Traits T2D Collaborative
Guidelines for investigating causality of sequence variants in human disease
Guidelines for investigating causality of sequence variants in human disease
D. G. MacArthur, T. A. Manolio, D. P. Dimmock, H. L. Rehm, J. Shendure, ..., S. R. Sunyaev, D. Valle, B. F. Voight, W. Winckler, C. Gunter
Nature   ·   01 Apr 2014   ·   doi:10.1038/nature13127
PubMed
Selected Work Complex Traits Collaborative Opinion/Review/Book Chapter
<i>SORT</i> ing Out That Pesky Cholesterol
SORT ing Out That Pesky Cholesterol
Benjamin F. Voight
Science Translational Medicine   ·   05 Mar 2014   ·   doi:10.1126/scitranslmed.3008715
Opinion/Review/Book Chapter
Loss-of-function mutations in SLC30A8 protect against type 2 diabetes
Loss-of-function mutations in SLC30A8 protect against type 2 diabetes
Jason Flannick, Gudmar Thorleifsson, Nicola L Beer, Suzanne B R Jacobs, Niels Grarup, ..., Oluf Pedersen, Leif Groop, David R Cox, Kari Stefansson, David Altshuler
Nature Genetics   ·   02 Mar 2014   ·   doi:10.1038/ng.2915
PubMed
Selected Work Complex Traits T2D Consortia Collaborative
Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility
Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility
Anubha Mahajan, Min Jin Go, Weihua Zhang, Jennifer E Below, Kyle J Gaulton, ..., Esteban J Parra, John C Chambers, E Shyong Tai, Mark I McCarthy, Andrew P Morris
Nature Genetics   ·   09 Feb 2014   ·   doi:10.1038/ng.2897
PubMed
Complex Traits T2D Consortia Collaborative
A Metabolic Relic
A Metabolic Relic
Benjamin F. Voight
Science Translational Medicine   ·   22 Jan 2014   ·   doi:10.1126/scitranslmed.3008436
Opinion/Review/Book Chapter

2013

Right Place, Right Time
Right Place, Right Time
Benjamin F. Voight
Science Translational Medicine   ·   04 Dec 2013   ·   doi:10.1126/scitranslmed.3008007
Opinion/Review/Book Chapter
Thinking Before We Act
Thinking Before We Act
Benjamin F. Voight
Science Translational Medicine   ·   23 Oct 2013   ·   doi:10.1126/scitranslmed.3007770
Opinion/Review/Book Chapter
Discovery and refinement of loci associated with lipid levels
Discovery and refinement of loci associated with lipid levels
[no author info]
Nature Genetics   ·   06 Oct 2013   ·   doi:10.1038/ng.2797
PubMed
Complex Traits Pleiotropy Consortia Collaborative
Common variants associated with plasma triglycerides and risk for coronary artery disease
Common variants associated with plasma triglycerides and risk for coronary artery disease
Ron Do, Cristen J Willer, Ellen M Schmidt, Sebanti Sengupta, Chi Gao, ..., Erik Ingelsson, Goncalo R Abecasis, Mark J Daly, Benjamin M Neale, Sekar Kathiresan
Nature Genetics   ·   06 Oct 2013   ·   doi:10.1038/ng.2795
PubMed
Complex Traits CAD/CVD Pleiotropy Collaborative
Ironing Out Parkinson’s Disease
Ironing Out Parkinson’s Disease
Benjamin F. Voight
Science Translational Medicine   ·   31 Jul 2013   ·   doi:10.1126/scitranslmed.3007047
Opinion/Review/Book Chapter
<i>RA-</i> cing Toward Drugs from a Genetics Starting Line
RA- cing Toward Drugs from a Genetics Starting Line
Benjamin F. Voight
Science Translational Medicine   ·   19 Jun 2013   ·   doi:10.1126/scitranslmed.3006750
Opinion/Review/Book Chapter
From Mouse to Human: Evolutionary Genomics Analysis of Human Orthologs of Essential Genes
From Mouse to Human: Evolutionary Genomics Analysis of Human Orthologs of Essential Genes
Benjamin Georgi, Benjamin F. Voight, Maja Bućan
PLoS Genetics   ·   09 May 2013   ·   doi:10.1371/journal.pgen.1003484
PubMed
Selected Work Pop Gen Selection
Eavesdropping on Communications Between Liver and β Cells
Eavesdropping on Communications Between Liver and β Cells
Benjamin F. Voight
Science Translational Medicine   ·   08 May 2013   ·   doi:10.1126/scitranslmed.3006452
Opinion/Review/Book Chapter
Accessing the Inaccessible Genome
Accessing the Inaccessible Genome
Benjamin F. Voight
Science Translational Medicine   ·   03 Apr 2013   ·   doi:10.1126/scitranslmed.3006206
Opinion/Review/Book Chapter

2012

Large-scale association analysis identifies new risk loci for coronary artery disease
Large-scale association analysis identifies new risk loci for coronary artery disease
Panos Deloukas, Stavroula Kanoni, Christina Willenborg, Martin Farrall, Themistocles L Assimes, ..., Colin N A Palmer, Robert Roberts, Hugh Watkins, Heribert Schunkert, Nilesh J Samani
Nature Genetics   ·   02 Dec 2012   ·   doi:10.1038/ng.2480
PubMed
Complex Traits CAD/CVD Consortia Collaborative
Identification of the <i>BCAR1-CFDP1-TMEM170A</i> Locus as a Determinant of Carotid Intima-Media Thickness and Coronary Artery Disease Risk
Identification of the BCAR1-CFDP1-TMEM170A Locus as a Determinant of Carotid Intima-Media Thickness and Coronary Artery Disease Risk
Karl Gertow, Bengt Sennblad, Rona J. Strawbridge, John Öhrvik, Delilah Zabaneh, ..., Damiano Baldassarre, Elena Tremoli, Ulf de Faire, Steve E. Humphries, Anders Hamsten
Circulation: Cardiovascular Genetics   ·   01 Dec 2012   ·   doi:10.1161/CIRCGENETICS.112.963660
PubMed
Complex Traits CAD/CVD Collaborative
Informed Conditioning on Clinical Covariates Increases Power in Case-Control Association Studies
Informed Conditioning on Clinical Covariates Increases Power in Case-Control Association Studies
Noah Zaitlen, Sara Lindström, Bogdan Pasaniuc, Marilyn Cornelis, Giulio Genovese, ..., David Altshuler, Benjamin Voight, Peter Kraft, Nick Patterson, Alkes L. Price
PLoS Genetics   ·   08 Nov 2012   ·   doi:10.1371/journal.pgen.1003032
PubMed
Complex Traits Collaborative
Human genetics offers an emerging picture of common pathways and mechanisms in autoimmunity
Human genetics offers an emerging picture of common pathways and mechanisms in autoimmunity
Benjamin F Voight, Chris Cotsapas
Current Opinion in Immunology   ·   01 Oct 2012   ·   doi:10.1016/j.coi.2012.07.013
PubMed
Opinion/Review/Book Chapter
Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes
Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes
Andrew P Morris, Benjamin F Voight, Tanya M Teslovich, Teresa Ferreira, Ayellet V Segrè, ..., Josée Dupuis, James B Meigs, David Altshuler, Michael Boehnke, Mark I McCarthy
Nature Genetics   ·   12 Aug 2012   ·   doi:10.1038/ng.2383
PubMed
Selected Work Complex Traits T2D Consortia Statistics
Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways
Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways
Robert A Scott, Vasiliki Lagou, Ryan P Welch, Eleanor Wheeler, May E Montasser, ..., Jose C Florez, Claudia Langenberg, Erik Ingelsson, Inga Prokopenko, Inês Barroso
Nature Genetics   ·   12 Aug 2012   ·   doi:10.1038/ng.2385
PubMed
Complex Traits T2D Collaborative
The Metabochip, a Custom Genotyping Array for Genetic Studies of Metabolic, Cardiovascular, and Anthropometric Traits
The Metabochip, a Custom Genotyping Array for Genetic Studies of Metabolic, Cardiovascular, and Anthropometric Traits
Benjamin F. Voight, Hyun Min Kang, Jun Ding, Cameron D. Palmer, Carlo Sidore, ..., Joel N. Hirschhorn, David Altshuler, Mark I. McCarthy, Gonçalo R. Abecasis, Michael Boehnke
PLoS Genetics   ·   02 Aug 2012   ·   doi:10.1371/journal.pgen.1002793
PubMed
Selected Work Complex Traits T2D CAD/CVD Pleiotropy Methods Development
Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study
Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study
Benjamin F Voight, Gina M Peloso, Marju Orho-Melander, Ruth Frikke-Schmidt, Maja Barbalic, ..., Daniel J Rader, Leena Peltonen, Stephen M Schwartz, David Altshuler, Sekar Kathiresan
The Lancet   ·   01 Aug 2012   ·   doi:10.1016/S0140-6736(12)60312-2
PubMed
PDF
News
Selected Work Complex Traits Mendelian Randomization CAD/CVD Pleiotropy Statistics
Impact of Common Variation in Bone-Related Genes on Type 2 Diabetes and Related Traits
Impact of Common Variation in Bone-Related Genes on Type 2 Diabetes and Related Traits
Liana K. Billings, Yi-Hsiang Hsu, Rachel J. Ackerman, Josée Dupuis, Benjamin F. Voight, ..., James S. Pankow, David Karasik, James B. Meigs, Douglas P. Kiel, Jose C. Florez
Diabetes   ·   17 Jul 2012   ·   doi:10.2337/db11-1515
PubMed
Complex Traits T2D Pleiotropy Collaborative
Stratifying Type 2 Diabetes Cases by BMI Identifies Genetic Risk Variants in LAMA1 and Enrichment for Risk Variants in Lean Compared to Obese Cases
Stratifying Type 2 Diabetes Cases by BMI Identifies Genetic Risk Variants in LAMA1 and Enrichment for Risk Variants in Lean Compared to Obese Cases
John R. B. Perry, Benjamin F. Voight, Loïc Yengo, Najaf Amin, Josée Dupuis, ..., Colin N. A. Palmer, Nicholas J. Wareham, Leif Groop, Timothy M. Frayling, Stéphane Cauchi
PLoS Genetics   ·   31 May 2012   ·   doi:10.1371/journal.pgen.1002741
PubMed
Selected Work Complex Traits T2D Pleiotropy
A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance
A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance
Alisa K Manning, Marie-France Hivert, Robert A Scott, Jonna L Grimsby, Nabila Bouatia-Naji, ..., Richard M Watanabe, Jose C Florez, Josée Dupuis, James B Meigs, Claudia Langenberg
Nature Genetics   ·   13 May 2012   ·   doi:10.1038/ng.2274
PubMed
Complex Traits Pleiotropy Consortia Collaborative
Analysis of case–control association studies with known risk variants
Analysis of case–control association studies with known risk variants
Noah Zaitlen, Bogdan Paşaniuc, Nick Patterson, Samuela Pollack, Benjamin Voight, ..., Christopher A. Haiman, Barbara E. Stranger, Emmanouil T. Dermitzakis, Peter Kraft, Alkes L. Price
Bioinformatics   ·   03 May 2012   ·   doi:10.1093/bioinformatics/bts259
PubMed
Complex Traits Collaborative
Meta-analysis identifies six new susceptibility loci for atrial fibrillation
Meta-analysis identifies six new susceptibility loci for atrial fibrillation
Patrick T Ellinor, Kathryn L Lunetta, Christine M Albert, Nicole L Glazer, Marylyn D Ritchie, ..., Daniel I Chasman, Susan R Heckbert, Emelia J Benjamin, Vilmundur Gudnason, Stefan Kääb
Nature Genetics   ·   29 Apr 2012   ·   doi:10.1038/ng.2261
PubMed
Complex Traits CAD/CVD Collaborative
Evaluation of the Metabochip Genotyping Array in African Americans and Implications for Fine Mapping of GWAS-Identified Loci: The PAGE Study
Evaluation of the Metabochip Genotyping Array in African Americans and Implications for Fine Mapping of GWAS-Identified Loci: The PAGE Study
Steven Buyske, Ying Wu, Cara L. Carty, Iona Cheng, Themistocles L. Assimes, ..., Karen L. Mohlke, Christopher A. Haiman, Ulrike Peters, Dana C. Crawford, Kari E. North
PLoS ONE   ·   23 Apr 2012   ·   doi:10.1371/journal.pone.0035651
PubMed
Complex Traits Pleiotropy
Patterns and rates of exonic de novo mutations in autism spectrum disorders
Patterns and rates of exonic de novo mutations in autism spectrum disorders
Benjamin M. Neale, Yan Kou, Li Liu, Avi Ma’ayan, Kaitlin E. Samocha, ..., Richard A. Gibbs, Kathryn Roeder, Gerard D. Schellenberg, James S. Sutcliffe, Mark J. Daly
Nature   ·   04 Apr 2012   ·   doi:10.1038/nature11011
PubMed
Complex Traits Mutation Rate Collaborative Statistics
Novel Loci for Adiponectin Levels and Their Influence on Type 2 Diabetes and Metabolic Traits: A Multi-Ethnic Meta-Analysis of 45,891 Individuals
Novel Loci for Adiponectin Levels and Their Influence on Type 2 Diabetes and Metabolic Traits: A Multi-Ethnic Meta-Analysis of 45,891 Individuals
Zari Dastani, Marie-France Hivert, Nicholas Timpson, John R. B. Perry, Xin Yuan, ..., Ruth J. F. Loos, Dawn M. Waterworth, James B. Meigs, Josee Dupuis, J. Brent Richards
PLoS Genetics   ·   29 Mar 2012   ·   doi:10.1371/journal.pgen.1002607
PubMed
Complex Traits Collaborative
Bayesian inference analyses of the polygenic architecture of rheumatoid arthritis
Bayesian inference analyses of the polygenic architecture of rheumatoid arthritis
Eli A Stahl, Daniel Wegmann, Gosia Trynka, Javier Gutierrez-Achury, Ron Do, ..., Katherine A Siminovitch, Jane Worthington, Paul I W de Bakker, Soumya Raychaudhuri, Robert M Plenge
Nature Genetics   ·   25 Mar 2012   ·   doi:10.1038/ng.2232
PubMed
Complex Traits Pleiotropy Collaborative
Large-Scale Gene-Centric Meta-Analysis across 39 Studies Identifies Type 2 Diabetes Loci
Large-Scale Gene-Centric Meta-Analysis across 39 Studies Identifies Type 2 Diabetes Loci
Richa Saxena, Clara C. Elbers, Yiran Guo, Inga Peter, Tom R. Gaunt, ..., Alex Reiner, Donald W. Bowden, Hakon Hakonarson, David S. Siscovick, Brendan J. Keating
The American Journal of Human Genetics   ·   01 Mar 2012   ·   doi:10.1016/j.ajhg.2011.12.022
PubMed
Complex Traits T2D Consortia Collaborative
Single-Cell Analysis Reveals that Noncoding RNAs Contribute to Clonal Heterogeneity by Modulating Transcription Factor Recruitment
Single-Cell Analysis Reveals that Noncoding RNAs Contribute to Clonal Heterogeneity by Modulating Transcription Factor Recruitment
Stacie L. Bumgarner, Gregor Neuert, Benjamin F. Voight, Anna Symbor-Nagrabska, Paula Grisafi, Alexander van Oudenaarden, Gerald R. Fink
Molecular Cell   ·   01 Feb 2012   ·   doi:10.1016/j.molcel.2011.11.029
PubMed
Selected Work Collaborative
A Genome-Wide Association Search for Type 2 Diabetes Genes in African Americans
A Genome-Wide Association Search for Type 2 Diabetes Genes in African Americans
Nicholette D. Palmer, Caitrin W. McDonough, Pamela J. Hicks, Bong H. Roh, Maria R. Wing, ..., Charles N. Rotimi, Maggie C. Y. Ng, Carl D. Langefeld, Barry I. Freedman, Donald W. Bowden
PLoS ONE   ·   04 Jan 2012   ·   doi:10.1371/journal.pone.0029202
PubMed
Complex Traits T2D Collaborative

2011

Genome-Wide Association Study for Coronary Artery Calcification With Follow-Up in Myocardial Infarction
Genome-Wide Association Study for Coronary Artery Calcification With Follow-Up in Myocardial Infarction
Christopher J. O'Donnell, Maryam Kavousi, Albert V. Smith, Sharon L.R. Kardia, Mary F. Feitosa, ..., Patricia A. Peyser, Ingrid B. Borecki, L. Adrienne Cupples, Vilmundur Gudnason, Jacqueline C.M. Witteman
Circulation   ·   01 Dec 2011   ·   doi:10.1161/CIRCULATIONAHA.110.974899
PubMed
Complex Traits CAD/CVD Consortia Collaborative
Genome-Wide Association Identifies Nine Common Variants Associated With Fasting Proinsulin Levels and Provides New Insights Into the Pathophysiology of Type 2 Diabetes
Genome-Wide Association Identifies Nine Common Variants Associated With Fasting Proinsulin Levels and Provides New Insights Into the Pathophysiology of Type 2 Diabetes
Rona J. Strawbridge, Josée Dupuis, Inga Prokopenko, Adam Barker, Emma Ahlqvist, ..., Richard M. Watanabe, Erik Ingelsson, Claudia Langenberg, Anders Hamsten, Jose C. Florez
Diabetes   ·   16 Sep 2011   ·   doi:10.2337/db11-0415
PubMed
Complex Traits T2D Consortia Collaborative
Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure
Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure
Louise V Wain, Germaine C Verwoert, Paul F O'Reilly, Gang Shi, Toby Johnson, ..., Mark J Caulfield, Dabeeru C Rao, Martin D Tobin, Paul Elliott, Cornelia M van Duijn
Nature Genetics   ·   11 Sep 2011   ·   doi:10.1038/ng.922
PubMed
Complex Traits Pleiotropy Collaborative
Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk
Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk
[no author info]
Nature   ·   11 Sep 2011   ·   doi:10.1038/nature10405
PubMed
Complex Traits MASLD Consortia Collaborative
Pervasive Sharing of Genetic Effects in Autoimmune Disease
Pervasive Sharing of Genetic Effects in Autoimmune Disease
Chris Cotsapas, Benjamin F. Voight, Elizabeth Rossin, Kasper Lage, Benjamin M. Neale, ..., Jane Worthington, John A. Todd, David A. Hafler, Stephen S. Rich, Mark J. Daly
PLoS Genetics   ·   10 Aug 2011   ·   doi:10.1371/journal.pgen.1002254
PubMed
GitHub
Selected Work Complex Traits Pleiotropy Statistics Methods Development Software
An Increased Burden of Common and Rare Lipid-Associated Risk Alleles Contributes to the Phenotypic Spectrum of Hypertriglyceridemia
An Increased Burden of Common and Rare Lipid-Associated Risk Alleles Contributes to the Phenotypic Spectrum of Hypertriglyceridemia
Christopher T. Johansen, Jian Wang, Matthew B. Lanktree, Adam D. McIntyre, Matthew R. Ban, ..., Salim Yusuf, Murray W. Huff, Sekar Kathiresan, Henian Cao, Robert A. Hegele
Arteriosclerosis, Thrombosis, and Vascular Biology   ·   01 Aug 2011   ·   doi:10.1161/ATVBAHA.111.226365
PubMed
Complex Traits CAD/CVD
A Genome-Wide Association Study Identifies <i>LIPA</i> as a Susceptibility Gene for Coronary Artery Disease
A Genome-Wide Association Study Identifies LIPA as a Susceptibility Gene for Coronary Artery Disease
Philipp S. Wild, Tanja Zeller, Arne Schillert, Silke Szymczak, Christoph R. Sinning, ..., Laurence Tiret, Veikko Salomaa, Thomas Munzel, Andreas Ziegler, Stefan Blankenberg
Circulation: Cardiovascular Genetics   ·   01 Aug 2011   ·   doi:10.1161/CIRCGENETICS.110.958728
PubMed
Complex Traits CAD/CVD
Influence of 9p21.3 Genetic Variants on Clinical and Angiographic Outcomes in Early-Onset Myocardial Infarction
Influence of 9p21.3 Genetic Variants on Clinical and Angiographic Outcomes in Early-Onset Myocardial Infarction
Diego Ardissino, Carlo Berzuini, Piera Angelica Merlini, Pier Mannuccio Mannucci, Aarti Surti, ..., Alberto Piazza, Luisa Foco, Luisa Bernardinelli, David Altshuler, Sekar Kathiresan
Journal of the American College of Cardiology   ·   01 Jul 2011   ·   doi:10.1016/j.jacc.2010.11.075
PubMed
Complex Traits CAD/CVD Consortia Collaborative
Genome-Wide Association Analysis Identifies Variants Associated with Nonalcoholic Fatty Liver Disease That Have Distinct Effects on Metabolic Traits
Genome-Wide Association Analysis Identifies Variants Associated with Nonalcoholic Fatty Liver Disease That Have Distinct Effects on Metabolic Traits
Elizabeth K. Speliotes, Laura M. Yerges-Armstrong, Jun Wu, Ruben Hernaez, Lauren J. Kim, ..., Caroline S. Fox, Albert V. Smith, W. H. Linda Kao, Joel N. Hirschhorn, Ingrid B. Borecki
PLoS Genetics   ·   10 Mar 2011   ·   doi:10.1371/journal.pgen.1001324
PubMed
Complex Traits T2D Consortia Collaborative
Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease
Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease
Heribert Schunkert, Inke R König, Sekar Kathiresan, Muredach P Reilly, Themistocles L Assimes, ..., Robert Roberts, Unnur Thorsteinsdottir, Christopher J O'Donnell, Ruth McPherson, Jeanette Erdmann
Nature Genetics   ·   06 Mar 2011   ·   doi:10.1038/ng.784
PubMed
Complex Traits CAD/CVD Consortia Collaborative
Testing for an Unusual Distribution of Rare Variants
Testing for an Unusual Distribution of Rare Variants
Benjamin M. Neale, Manuel A. Rivas, Benjamin F. Voight, David Altshuler, Bernie Devlin, Marju Orho-Melander, Sekar Kathiresan, Shaun M. Purcell, Kathryn Roeder, Mark J. Daly
PLoS Genetics   ·   03 Mar 2011   ·   doi:10.1371/journal.pgen.1001322
PubMed
Complex Traits Statistics Methods Development Software
Power in the phenotypic extremes: a simulation study of power in discovery and replication of rare variants
Power in the phenotypic extremes: a simulation study of power in discovery and replication of rare variants
Lin T. Guey, Jasmina Kravic, Olle Melander, Noël P. Burtt, Jason M. Laramie, ..., Sekar Kathiresan, Leif Groop, Albert B. Seymour, David Altshuler, Benjamin F. Voight
Genetic Epidemiology   ·   09 Feb 2011   ·   doi:10.1002/gepi.20572
PubMed
Selected Work Complex Traits T2D Pleiotropy Statistics Methods Development
Delineating Signals from Association Studies
Delineating Signals from Association Studies
Benjamin F. Voight
Analysis of Complex Disease Association Studies   ·   01 Jan 2011   ·   doi:10.1016/B978-0-12-375142-3.10017-3
Complex Traits Opinion/Review/Book Chapter

2010

Lack of Association Between the Trp719Arg Polymorphism in Kinesin-Like Protein-6 and Coronary Artery Disease in 19 Case-Control Studies
Lack of Association Between the Trp719Arg Polymorphism in Kinesin-Like Protein-6 and Coronary Artery Disease in 19 Case-Control Studies
Themistocles L. Assimes, Hilma Hólm, Sekar Kathiresan, Muredach P. Reilly, Gudmar Thorleifsson, ..., Unnur Thorsteinsdottir, Kari Stefansson, Heribert Schunkert, Nilesh J. Samani, Thomas Quertermous
Journal of the American College of Cardiology   ·   01 Nov 2010   ·   doi:10.1016/j.jacc.2010.06.022
PubMed
Complex Traits CAD/CVD Collaborative
Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution
Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution
Iris M Heid, Anne U Jackson, Joshua C Randall, Thomas W Winkler, Lu Qi, ..., Inês Barroso, Mark I McCarthy, Caroline S Fox, Karen L Mohlke, Cecilia M Lindgren
Nature Genetics   ·   10 Oct 2010   ·   doi:10.1038/ng.685
PubMed
Complex Traits Consortia Collaborative
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index
Elizabeth K Speliotes, Cristen J Willer, Sonja I Berndt, Keri L Monda, Gudmar Thorleifsson, ..., Kari E North, Mark I McCarthy, Joel N Hirschhorn, Erik Ingelsson, Ruth J F Loos
Nature Genetics   ·   10 Oct 2010   ·   doi:10.1038/ng.686
PubMed
Complex Traits Consortia Collaborative
Design of the Coronary ARtery DIsease Genome-Wide Replication And Meta-Analysis (CARDIoGRAM) Study
Design of the Coronary ARtery DIsease Genome-Wide Replication And Meta-Analysis (CARDIoGRAM) Study
Michael Preuss, Inke R. König, John R. Thompson, Jeanette Erdmann, Devin Absher, ..., Andreas Ziegler, Sekar Kathiresan, Muredach P. Reilly, Nilesh J. Samani, Heribert Schunkert
Circulation: Cardiovascular Genetics   ·   01 Oct 2010   ·   doi:10.1161/CIRCGENETICS.109.899443
PubMed
Complex Traits CAD/CVD Consortia Collaborative
Hundreds of variants clustered in genomic loci and biological pathways affect human height
Hundreds of variants clustered in genomic loci and biological pathways affect human height
Hana Lango Allen, Karol Estrada, Guillaume Lettre, Sonja I. Berndt, Michael N. Weedon, ..., Cecilia M. Lindgren, Gonçalo R. Abecasis, Kari Stefansson, Timothy M. Frayling, Joel N. Hirschhorn
Nature   ·   29 Sep 2010   ·   doi:10.1038/nature09410
PubMed
Complex Traits Consortia Collaborative
Common Variants at 10 Genomic Loci Influence Hemoglobin A1C Levels via Glycemic and Nonglycemic Pathways
Common Variants at 10 Genomic Loci Influence Hemoglobin A1C Levels via Glycemic and Nonglycemic Pathways
Nicole Soranzo, Serena Sanna, Eleanor Wheeler, Christian Gieger, Dörte Radke, ..., Manjinder S. Sandhu, Matthew M. Heeney, Joseph M. Devaney, Muredach P. Reilly, Sally L. Ricketts
Diabetes   ·   21 Sep 2010   ·   doi:10.2337/db10-0502
PubMed
Complex Traits T2D Pleiotropy Consortia Collaborative
Multiethnic Genetic Association Studies Improve Power for Locus Discovery
Multiethnic Genetic Association Studies Improve Power for Locus Discovery
Sara L. Pulit, Benjamin F. Voight, Paul I. W. de Bakker
PLoS ONE   ·   08 Sep 2010   ·   doi:10.1371/journal.pone.0012600
PubMed
Selected Work Complex Traits Pop Gen Statistics
Biological, clinical and population relevance of 95 loci for blood lipids
Biological, clinical and population relevance of 95 loci for blood lipids
Tanya M. Teslovich, Kiran Musunuru, Albert V. Smith, Andrew C. Edmondson, Ioannis M. Stylianou, ..., Cornelia M. van Duijn, Leena Peltonen, Gonçalo R. Abecasis, Michael Boehnke, Sekar Kathiresan
Nature   ·   01 Aug 2010   ·   doi:10.1038/nature09270
PubMed
Complex Traits Consortia Collaborative
Excess of rare variants in genes identified by genome-wide association study of hypertriglyceridemia
Excess of rare variants in genes identified by genome-wide association study of hypertriglyceridemia
Christopher T Johansen, Jian Wang, Matthew B Lanktree, Henian Cao, Adam D McIntyre, ..., Sonia S Anand, Salim Yusuf, Murray W Huff, Sekar Kathiresan, Robert A Hegele
Nature Genetics   ·   25 Jul 2010   ·   doi:10.1038/ng.628
PubMed
Complex Traits CAD/CVD Collaborative
Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis
Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis
Benjamin F Voight, Laura J Scott, Valgerdur Steinthorsdottir, Andrew P Morris, Christian Dina, ..., Cornelia M van Duijn, Kari Stefansson, David Altshuler, Michael Boehnke, Mark I McCarthy
Nature Genetics   ·   27 Jun 2010   ·   doi:10.1038/ng.609
PubMed
Selected Work Complex Traits T2D Consortia
<i>PNPLA3</i>variants specifically confer increased risk for histologic nonalcoholic fatty liver disease but not metabolic disease
PNPLA3variants specifically confer increased risk for histologic nonalcoholic fatty liver disease but not metabolic disease
Elizabeth K. Speliotes, Johannah L. Butler, Cameron D. Palmer, Benjamin F. Voight, Joel N. Hirschhorn
Hepatology   ·   18 May 2010   ·   doi:10.1002/hep.23768
PubMed
Complex Traits MASLD Consortia Collaborative
Genome-wide meta-analyses identify multiple loci associated with smoking behavior
Genome-wide meta-analyses identify multiple loci associated with smoking behavior
[no author info]
Nature Genetics   ·   25 Apr 2010   ·   doi:10.1038/ng.571
PubMed
Complex Traits Consortia Collaborative
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk
Josée Dupuis, Claudia Langenberg, Inga Prokopenko, Richa Saxena, Nicole Soranzo, ..., Igor Rudan, Alan F Wright, Michael Stumvoll, Harry Campbell, James F Wilson
Nature Genetics   ·   17 Jan 2010   ·   doi:10.1038/ng.520
PubMed
Complex Traits T2D Pleiotropy Collaborative
Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge
Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge
Richa Saxena, Marie-France Hivert, Claudia Langenberg, Toshiko Tanaka, James S Pankow, ..., Gérard Waeber, Andrew Walley, Dawn M Waterworth, Eleftheria Zeggini, Jing Hua Zhao
Nature Genetics   ·   17 Jan 2010   ·   doi:10.1038/ng.521
PubMed
Complex Traits T2D Pleiotropy Collaborative

2009

A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium
A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium
Nicole Soranzo, Tim D Spector, Massimo Mangino, Brigitte Kühnel, Augusto Rendon, ..., Christa Meisinger, Andreas Greinacher, Panos Deloukas, Willem H Ouwehand, Christian Gieger
Nature Genetics   ·   11 Oct 2009   ·   doi:10.1038/ng.467
PubMed
Complex Traits Pleiotropy Consortia Collaborative
Underlying Genetic Models of Inheritance in Established Type 2 Diabetes Associations
Underlying Genetic Models of Inheritance in Established Type 2 Diabetes Associations
Georgia Salanti, Lorraine Southam, David Altshuler, Kristin Ardlie, Inês Barroso, ..., Laura J. Scott, Benjamin F. Voight, Nicholas J. Wareham, Eleftheria Zeggini, John P. A. Ioannidis
American Journal of Epidemiology   ·   14 Jul 2009   ·   doi:10.1093/aje/kwp145
PubMed
Complex Traits T2D Collaborative
Common body mass index-associated variants confer risk of extreme obesity
Common body mass index-associated variants confer risk of extreme obesity
Chris Cotsapas, Elizabeth K. Speliotes, Ida J. Hatoum, Danielle M. Greenawalt, Radu Dobrin, ..., Benjamin M. Neale, Eric E. Schadt, Joel N. Hirschhorn, Lee M. Kaplan, Mark J. Daly
Human Molecular Genetics   ·   24 Jun 2009   ·   doi:10.1093/hmg/ddp292
PubMed
Complex Traits Consortia Collaborative
Genome-wide association study identifies eight loci associated with blood pressure
Genome-wide association study identifies eight loci associated with blood pressure
Christopher Newton-Cheh, Toby Johnson, Vesela Gateva, Martin D Tobin, Murielle Bochud, ..., Ruth JF Loos, Paul Elliott, Gonçalo R Abecasis, Mark Caulfield, Patricia B Munroe
Nature Genetics   ·   10 May 2009   ·   doi:10.1038/ng.361
PubMed
Complex Traits Consortia Collaborative
Linkage Disequilibrium Mapping of the Replicated Type 2 Diabetes Linkage Signal on Chromosome 1q
Linkage Disequilibrium Mapping of the Replicated Type 2 Diabetes Linkage Signal on Chromosome 1q
Inga Prokopenko, Eleftheria Zeggini, Robert L. Hanson, Braxton D. Mitchell, N. William Rayner, ..., Steven C. Elbein, Panos Deloukas, Clifton Bogardus, Alan R. Shuldiner, Mark I. McCarthy
Diabetes   ·   23 Apr 2009   ·   doi:10.2337/db09-0081
PubMed
Complex Traits T2D Collaborative
The T-381C SNP in BNP gene may be modestly associated with type 2 diabetes: an updated meta-analysis in 49 279 subjects
The T-381C SNP in BNP gene may be modestly associated with type 2 diabetes: an updated meta-analysis in 49 279 subjects
Hélène Choquet, Christine Cavalcanti-Proença, Cécile Lecoeur, Christian Dina, Stéphane Cauchi, ..., Valgerdur Steinthorsdottir, Kari Stefansson, Beverley Balkau, Philippe Froguel, David Meyre
Human Molecular Genetics   ·   18 Apr 2009   ·   doi:10.1093/hmg/ddp169
PubMed
Complex Traits T2D Collaborative
New susceptibility locus for coronary artery disease on chromosome 3q22.3
New susceptibility locus for coronary artery disease on chromosome 3q22.3
Jeanette Erdmann, Anika Großhennig, Peter S Braund, Inke R König, Christian Hengstenberg, ..., Panos Deloukas, John R Thompson, Andreas Ziegler, Nilesh J Samani, Heribert Schunkert
Nature Genetics   ·   08 Feb 2009   ·   doi:10.1038/ng.307
PubMed
Complex Traits CAD/CVD Collaborative
Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants
Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants
[no author info]
Nature Genetics   ·   08 Feb 2009   ·   doi:10.1038/ng.327
PubMed
Selected Work Complex Traits CAD/CVD Consortia

2008

Variants in MTNR1B influence fasting glucose levels
Variants in MTNR1B influence fasting glucose levels
Inga Prokopenko, Claudia Langenberg, Jose C Florez, Richa Saxena, Nicole Soranzo, ..., Kari Stefansson, Mark I McCarthy, Nicholas J Wareham, James B Meigs, Gonçalo R Abecasis
Nature Genetics   ·   07 Dec 2008   ·   doi:10.1038/ng.290
PubMed
Complex Traits T2D Consortia Collaborative
Common variants at 30 loci contribute to polygenic dyslipidemia
Common variants at 30 loci contribute to polygenic dyslipidemia
Sekar Kathiresan, Cristen J Willer, Gina M Peloso, Serkalem Demissie, Kiran Musunuru, ..., Jose M Ordovas, Michael Boehnke, Gonçalo R Abecasis, Karen L Mohlke, L Adrienne Cupples
Nature Genetics   ·   07 Dec 2008   ·   doi:10.1038/ng.291
PubMed
Complex Traits Pleiotropy Consortia Collaborative
Common Missense Variant in the Glucokinase Regulatory Protein Gene Is Associated With Increased Plasma Triglyceride and C-Reactive Protein but Lower Fasting Glucose Concentrations
Common Missense Variant in the Glucokinase Regulatory Protein Gene Is Associated With Increased Plasma Triglyceride and C-Reactive Protein but Lower Fasting Glucose Concentrations
Marju Orho-Melander, Olle Melander, Candace Guiducci, Pablo Perez-Martinez, Dolores Corella, ..., Peter Nilsson, Leif Groop, David Altshuler, Jose M. Ordovas, Sekar Kathiresan
Diabetes   ·   01 Nov 2008   ·   doi:10.2337/db08-0516
PubMed
Complex Traits T2D Consortia Collaborative
Practical aspects of imputation-driven meta-analysis of genome-wide association studies
Practical aspects of imputation-driven meta-analysis of genome-wide association studies
P. I.W. de Bakker, M. A.R. Ferreira, X. Jia, B. M. Neale, S. Raychaudhuri, B. F. Voight
Human Molecular Genetics   ·   15 Oct 2008   ·   doi:10.1093/hmg/ddn288
PubMed
Selected Work Complex Traits Statistics Opinion/Review/Book Chapter
Common variants near MC4R are associated with fat mass, weight and risk of obesity
Common variants near MC4R are associated with fat mass, weight and risk of obesity
Ruth J F Loos, Cecilia M Lindgren, Shengxu Li, Eleanor Wheeler, Jing Hua Zhao, ..., Vincent Mooser, Panos Deloukas, Mark I McCarthy, Nicholas J Wareham, Inês Barroso
Nature Genetics   ·   04 May 2008   ·   doi:10.1038/ng.140
PubMed
Complex Traits Collaborative
Identification of ten loci associated with height highlights new biological pathways in human growth
Identification of ten loci associated with height highlights new biological pathways in human growth
Guillaume Lettre, Anne U Jackson, Christian Gieger, Fredrick R Schumacher, Sonja I Berndt, ..., Richard B Hayes, Gonçalo R Abecasis, H-Erich Wichmann, Karen L Mohlke, Joel N Hirschhorn
Nature Genetics   ·   06 Apr 2008   ·   doi:10.1038/ng.125
PubMed
Complex Traits Collaborative
Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes
Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes
Eleftheria Zeggini, Laura J Scott, Richa Saxena, Benjamin F Voight, Jonathan L Marchini, ..., Francis S Collins, Leif Groop, Mark I McCarthy, Michael Boehnke, David Altshuler
Nature Genetics   ·   30 Mar 2008   ·   doi:10.1038/ng.120
PubMed
Selected Work Complex Traits T2D Consortia
Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans
Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans
Sekar Kathiresan, Olle Melander, Candace Guiducci, Aarti Surti, Noël P Burtt, ..., Veikko Salomaa, Leena Peltonen, Leif Groop, David M Altshuler, Marju Orho-Melander
Nature Genetics   ·   13 Jan 2008   ·   doi:10.1038/ng.75
PubMed
Complex Traits Pleiotropy Collaborative

2007

A common variant of HMGA2 is associated with adult and childhood height in the general population
A common variant of HMGA2 is associated with adult and childhood height in the general population
Michael N Weedon, Guillaume Lettre, Rachel M Freathy, Cecilia M Lindgren, Benjamin F Voight, ..., Leif C Groop, Andrew T Hattersley, Mark I McCarthy, Joel N Hirschhorn, Timothy M Frayling
Nature Genetics   ·   02 Sep 2007   ·   doi:10.1038/ng2121
PubMed
PDF
Complex Traits Pleiotropy Collaborative
Genome-Wide Association Analysis Identifies Loci for Type 2 Diabetes and Triglyceride Levels
Genome-Wide Association Analysis Identifies Loci for Type 2 Diabetes and Triglyceride Levels
Richa Saxena, Benjamin F. Voight, Valeriya Lyssenko, Noël P. Burtt, Paul I. W. de Bakker, ..., Qicheng Ma, Hemang Parikh, Delwood Richardson, Darrell Ricke, Shaun Purcell
Science   ·   01 Jun 2007   ·   doi:10.1126/science.1142358
PubMed
PDF
News
Selected Work Complex Traits T2D Consortia

2006

Convergent adaptation of human lactase persistence in Africa and Europe
Convergent adaptation of human lactase persistence in Africa and Europe
Sarah A Tishkoff, Floyd A Reed, Alessia Ranciaro, Benjamin F Voight, Courtney C Babbitt, ..., Jilur Ghori, Suzannah Bumpstead, Jonathan K Pritchard, Gregory A Wray, Panos Deloukas
Nature Genetics   ·   10 Dec 2006   ·   doi:10.1038/ng1946
PubMed
PDF
News
Selected Work Pop Gen Selection Collaborative
Coverage and Characteristics of the Affymetrix GeneChip Human Mapping 100K SNP Set
Coverage and Characteristics of the Affymetrix GeneChip Human Mapping 100K SNP Set
Dan L Nicolae, Xiaoquan Wen, Benjamin F Voight, Nancy J Cox
PLoS Genetics   ·   05 May 2006   ·   doi:10.1371/journal.pgen.0020067
PubMed
PDF
Complex Traits
A Map of Recent Positive Selection in the Human Genome
A Map of Recent Positive Selection in the Human Genome
Benjamin F Voight, Sridhar Kudaravalli, Xiaoquan Wen, Jonathan K Pritchard
PLoS Biology   ·   07 Mar 2006   ·   doi:10.1371/journal.pbio.0040072
PubMed
PDF
GitHub
News
Selected Work Pop Gen Selection Statistics Methods Development Software

2005

Interrogating multiple aspects of variation in a full resequencing data set to infer human population size changes
Interrogating multiple aspects of variation in a full resequencing data set to infer human population size changes
Benjamin F. Voight, Alison M. Adams, Linda A. Frisse, Yudong Qian, Richard R. Hudson, Anna Di Rienzo
Proceedings of the National Academy of Sciences   ·   13 Dec 2005   ·   doi:10.1073/pnas.0507325102
PubMed
PDF
Selected Work Pop Gen Statistics Methods Development
Confounding from Cryptic Relatedness in Case-Control Association Studies
Confounding from Cryptic Relatedness in Case-Control Association Studies
Benjamin F Voight, Jonathan K Pritchard
PLoS Genetics   ·   02 Sep 2005   ·   doi:10.1371/journal.pgen.0010032
PubMed
PDF
Selected Work Complex Traits Pop Gen Statistics