Publications
We have created extensive scholarship around method development and analysis of genetic data in humans, the central focus of my lab.
My roots began in population genetics, aiming to understand how the genome reveals details of our evolutionary history. Today, we are very are active in the development of methods in population genomics, which include characterization of mutation rates and studies of natural selection in human populations.
We are actively interested in the genetic dissection of complex traits. The statistical pipelines that we have developed and applied over my career have resulting in discovery of thousands of loci for complex traits, focused on type 2 diabetes, cardiovascular disease, and liver disease. This also include mapping of genetic variation associated with molecular phenotypes (eQTLs, sQTLs, caQTLs, etc.) using bulk tissue, cell model, and even single-cell resources in tissues relevant to these endpoints (e.g., pancreas).
We also have an active interest in the application of Mendelian randomization (MR) to evaluate causal hypotheses between biomarkers and cardiometabolic endpoints, including most famously rejecting a protective role for HDL Cholesterol in heart disease.
I need to prettify the publication listing below (Work in progress)!
But feel free to follow the Pubmed and Google Scholar links below to see a full list of my publications.
All
Selected Works:
Discipline/Approach Areas:
Phenotypic Areas:
Consortia Work:
Approaches/Software:
Clear search
2025
2024
2023
2022




2021
2020
2019
2018
2017
2016
2015
2014
2013
2012

2011
2010
2009
2008
2007


2006

2005
